Insights into Peptide Mediated Antibiofilm Treatment in Chronic Wound: A Bench to Bedside Approach

Title:Insights into Peptide Mediated Antibiofilm Treatment in Chronic Wound: A Bench to Bedside Approach

Volume: 22 Issue: 1

Author(s): Megha P. Radhakrishnan, Karthika Suryaletha, Aparna Shankar, Akhila Velappan Savithri, Sanil George and Sabu Thomas*

Affiliation:

• Cholera and Biofilm Research Laboratory, Pathogen Biology Group, Rajiv Gandhi Centre for Biotechnology, Govt. of India, Trivandrum - 695 014, Kerala,India

Keywords: Bacterial biofilm, antibiofilm agent, anti-microbial peptides (AMPs), delayed wound healing, combinatorial therapy, chronic.

Abstract: Chronic wound biofilm infections are a threat to the population with respect to morbidity and mortality. The presence of multidrug-resistant bacterial pathogens in chronic wound renders the action of antibiotics and antibiofilm agents difficult. Therefore an alternative therapy is essential for reducing bacterial biofilm burden. In this scenario, the peptide-based antibiofilm therapy for chronic wound biofilm management seeks more attention. A synthetic peptide with a broad range of antibiofilm activity against preformed and established biofilms, having the ability to kill multispecies bacteria within biofilms and possessing combinatorial activity with other antimicrobial agents, provides significant insights. In this review, we portray the possibilities and difficulties of peptide-mediated treatment in chronic wounds biofilm management and how it can be clinically translated into a product.

Cite this article as:

Radhakrishnan P. Megha , Suryaletha Karthika , Shankar Aparna , Savithri Velappan Akhila , George Sanil and Thomas Sabu*, Insights into Peptide Mediated Antibiofilm Treatment in Chronic Wound: A Bench to Bedside Approach, Current Protein & Peptide Science 2021; 22 (1) . https://dx.doi.org/10.2174/1389203721666201103084727