Abstract
Introduction: The ongoing pandemic of Severe Acute Respiratory Syndrome coronavirus-2 (SARS COV-2) has jeopardized people’s health and the global economy. The infection caused by these viruses inflicts immunosuppression and an unprecedented range of symptoms leading to mortality. At this stage, there are no countermeasures or medicines to overcome rapid disease proliferation and aberrant immunological response.
Objectives: The study aims to determine different immunomodulatory therapeutics that could be potential agents to alleviate viral and other lethal infections and possibly rejuvenate immunological and tissue repair response against this disease.
Methods: A review of the literature was performed by screening different scientific databases to procure various immunomodulatory therapies for the treatment of SAR COV-2.
Results: A comprehensive literature review indicated that different foods rich in vitamins (A-D), selenium and iron can enhance immunological response against various deleterious infections, whereas different nutritious drinks that include hydrogen-enriched water and green tea alleviate inflammation and elicit wound healing properties. Black cumin seeds and Garlic have a myriad of biological activities due to abundant bioactive phytochemicals that play an important role in the elimination of various bacterial and viral infections.
Conclusion: These foods/supplements are relatively safe to consume and possess high toxicity profile and could be a potential nutritional intervention in order to create adequate immunity within a population to fight against this prevailing infection.
Keywords: Novel coronavirus 19, immunity, nutrition, treatment, prevention, therapeutics, severe acute respiratory syndrome coronavirus-2
[http://dx.doi.org/10.1056/NEJMe2001126]
[http://dx.doi.org/10.1016/S1473-3099(20)30395-9] [PMID: 32422197]
[http://dx.doi.org/10.1016/j.copsyc.2015.03.007] [PMID: 26086030]
[http://dx.doi.org/10.1093/cid/ciaa272]
[http://dx.doi.org/10.1001/jamaoto.2020.0832]
[http://dx.doi.org/10.1016/j.jaut.2020.102433] [PMID: 32113704]
[http://dx.doi.org/10.1016/j.cpcardiol.2020.100618] [PMID: 32439197]
[http://dx.doi.org/10.1016/S1473-3099(20)30232-2]
[http://dx.doi.org/10.4103/0976-0105.128253] [PMID: 24808684]
[http://dx.doi.org/10.1016/S0140-6736(20)30357-3] [PMID: 32059801]
[http://dx.doi.org/10.3961/jpmph.20.094.]
[http://dx.doi.org/10.4103/2045-9912.222448] [PMID: 29497485]
[http://dx.doi.org/10.1016/j.pharmthera.2014.04.006] [PMID: 24769081]
[http://dx.doi.org/10.15761/JTS.1000380]
[http://dx.doi.org/10.2174/13816128113199990507] [PMID: 23859555]
[http://dx.doi.org/10.18632/oncotarget.21130] [PMID: 29254278]
[http://dx.doi.org/10.3945/jn.115.229708] [PMID: 27511929]
[http://dx.doi.org/10.1038/491680a] [PMID: 23192143]
[http://dx.doi.org/10.5114/ceji.2014.43716] [PMID: 26155118]
[PMID: 24592582]
[http://dx.doi.org/10.1038/nri2378] [PMID: 19172691]
[http://dx.doi.org/10.3390/nu12010236] [PMID: 31963293]
[http://dx.doi.org/10.3390/nu8020068] [PMID: 26828517]
[http://dx.doi.org/10.1371/journal.pone.0123460]
[http://dx.doi.org/10.1155/2019/7286737] [PMID: 31934267]
[http://dx.doi.org/10.3389/fphys.2015.00397] [PMID: 26779027]
[http://dx.doi.org/10.1016/j.mrfmmm.2011.12.001] [PMID: 22178550]
[http://dx.doi.org/10.12968/bjcn.2013.18.Sup12.S6]]
[http://dx.doi.org/10.3390/nu9111211] [PMID: 29099763]
[http://dx.doi.org/10.1002/14651858.CD013292]
[http://dx.doi.org/10.1111/odi.12446] [PMID: 26808119]
[http://dx.doi.org/10.1186/s13054-020-02851-4] [PMID: 32264963]
[http://dx.doi.org/10.1111/nyas.12129] [PMID: 23682710]
[http://dx.doi.org/10.2310/JIM.0b013e31821b8755] [PMID: 21527855]
[http://dx.doi.org/10.1016/j.clinthera.2017.03.021] [PMID: 28438353]
[http://dx.doi.org/10.1007/s00223-012-9619-0] [PMID: 22782502]
[http://dx.doi.org/10.2174/18715281113129990046] [PMID: 23782205]
[http://dx.doi.org/10.3390/nu12040988]
[PMID: 32603576]
[http://dx.doi.org/10.3390/nu12051359] [PMID: 32397511]
[http://dx.doi.org/10.1089/ars.2010.3275] [PMID: 20812787]
[http://dx.doi.org/10.1016/S0140-6736(11)61452-9] [PMID: 22381456]
[http://dx.doi.org/10.1039/C3MT00185G] [PMID: 24185753]
[http://dx.doi.org/10.1038/nm0595-433] [PMID: 7585090]
[http://dx.doi.org/10.1096/fj.00-0721fje] [PMID: 11387264]
[http://dx.doi.org/10.1089/ars.2011.4145] [PMID: 21955027]
[http://dx.doi.org/10.1016/j.dsx.2020.04.015]
[http://dx.doi.org/10.1007/s00005-010-0095-9] [PMID: 20878249]
[http://dx.doi.org/10.3389/fphar.2014.00152] [PMID: 25076907]
[http://dx.doi.org/10.3390/nu10101466] [PMID: 30304813]
[http://dx.doi.org/10.1038/s41598-019-49122-z] [PMID: 31477792]
[PMID: 24379960]
[http://dx.doi.org/10.1016/j.biopha.2019.109730] [PMID: 31877551]
[http://dx.doi.org/10.1155/2015/401630] [PMID: 25961060]
[http://dx.doi.org/10.1097/DSS.0000000000001382] [PMID: 29077629]
[PMID: 25050296]
[http://dx.doi.org/10.1016/j.bbi.2020.04.077] [PMID: 32360439]
[http://dx.doi.org/10.1161/CIRCULATIONAHA.120.046941]
[http://dx.doi.org/10.1155/2018/9105261] [PMID: 30105263]
[http://dx.doi.org/10.1007/978-3-319-23672-8_4]
[http://dx.doi.org/10.3390/molecules22081337] [PMID: 28805687]
[http://dx.doi.org/10.1111/j.1440-1681.2012.05673.x] [PMID: 22229384]
[http://dx.doi.org/10.1093/fqsafe/fyx031]
[http://dx.doi.org/10.1016/S2221-1691(13)60075-1] [PMID: 23646296]
[http://dx.doi.org/10.1155/2019/1528635]
[PMID: 25859296]
[http://dx.doi.org/10.2217/fvl-2020-0079]