Increased Rates of Coronary Artery Calcium Score in Patients with Non - Functioning Adrenal Incidentaloma

Title:Increased Rates of Coronary Artery Calcium Score in Patients with Non - Functioning Adrenal Incidentaloma

Volume: 21 Issue: 7

Author(s): Oguz Akkus*, Gamze Akkus, Onur Kaypakli, Fatma K. Ozturk, Eren Gurkan, Ozkan Bekler, Fatih Sen and Fatih Yalcin

Affiliation:

• Department of Cardiology, Mustafa Kemal University, Hatay,Turkey

Keywords: Non-functioning adrenal incidentalomas, coronary-artery calcification, computed tomography, agatston score, adrenocorticotropic-hormone, lipoprotein.

Abstract:

Aim: We evaluated cardiovascular (CV) risk stratification for nonfunctioning adrenal incidentalomas (NFAIs) via the coronary-artery-calcium (CAC) score.

Materials and Methods: The participants were patients with NFAI (n = 55). They were compared to patients with chest pain, a low-intermediate Framingham-risk score, and a non-diagnostic treadmill- exercise test, which served as the control group (n = 49). Subsequently, the NFAI group was subdivided according to a CAC score of <100 Agatston units – mild coronary-artery calcification (n = 40) – and ≥100 Agatston units – moderate-to-severe calcification (n = 15).

Results: Similar rates of traditional risk factors were observed between the NFAI and control groups, and lower low-density lipoprotein cholesterol rates were observed in the NFAI group. The CAC score was significantly higher for the NFAI group than the control group. Glucose, potassium, adrenocorticotropic-hormone, and basal-cortisol levels were higher in those with a CAC score of ≥100. High-density-lipoprotein cholesterol estimated glomerular filtration rate and ejection fraction (EF) were higher in those with a CAC score of <100. Adenoma size and location were similar between the groups. Age, EF, and glucose were the most significant variables related to CAC score in patients with NFAI, at ≥100 Agatston units.

Discussion: Patients with a low-intermediate CV risk profile and NFAI have a higher risk of atherosclerosis when compared to patients with a low-intermediate CV risk profile, but no NFAI.

Conclusion: In patients with NFAI, CAC score evaluation may be used to predict increased atherosclerosis, especially in patients of an older age with higher glucose and decreased EF.

Cite this article as:

Akkus Oguz*, Akkus Gamze , Kaypakli Onur , Ozturk K. Fatma , Gurkan Eren , Bekler Ozkan , Sen Fatih and Yalcin Fatih , Increased Rates of Coronary Artery Calcium Score in Patients with Non - Functioning Adrenal Incidentaloma, Endocrine, Metabolic & Immune Disorders - Drug Targets 2021; 21 (7) . https://dx.doi.org/10.2174/1871530320666200910110337