MicroRNA-Targeted Signaling Pathways in the Autism Spectrum Disorder: Implications for Early Detection and Targeted Therapy

Title:MicroRNA-Targeted Signaling Pathways in the Autism Spectrum Disorder: Implications for Early Detection and Targeted Therapy

Volume: 20 Issue: 1

Author(s): Rasoul Alizadeh, Zahra Bahmanpoor, Shahabeddin Jalali-Qomi, Mahdi Amiri, Hamed Afkhami, Mansoor Khaledi, Reza Moosavi and Mansoureh Akouchekian*

Affiliation:

• Department of Medical Genetics and Molecular Biology, School of Medicine, Iran University of Medical Sciences, Tehran,Iran

Keywords: Autism Spectrum Disorder, pathways, miRNA, In silico analysis, genes, PI3K-Akt signaling pathway.

Abstract:

Background & Objective: Autism Spectrum Disorders (ASD) is known as a neurodevelopmental disorder showing communication impairments and unusual patterns of behavior. Presently, it seems that ASD frequency is on the increase. Therefore, diagnostic tools that help detect the disease in the early stages can be very useful in better management of the disease. Recent studies demonstrate that miRNAs as novel biomarkers can be used to find out the process and etiology of ASD by regulating various genes of multiple pathways. However, ASD associated pathway targeted by miRNA is still in infancy.

Methods: In this in silico study taking into consideration the importance of miRNAs, we reviewed bioinformatics databases for finding possible pathways and potential miRNAs related to selected pathways.

Results: The results displayed some prominent pathways involved in ASD, as well as some experimental and predicted miRNAs that may regulate targets associated with these pathways such as neuroactive ligand-receptor interaction, serotonergic synapse, calcium signaling pathway, cAMP Signaling Pathway, PI3K-Akt signaling pathway.

Conclusion: This study showed that the identified miRNAs may be involved in ASD-related pathways and may be considered as a new diagnostic tool and provide potential targets for the treatment of ASD.

Cite this article as:

Alizadeh Rasoul, Bahmanpoor Zahra , Jalali-Qomi Shahabeddin , Amiri Mahdi , Afkhami Hamed , Khaledi Mansoor , Moosavi Reza and Akouchekian Mansoureh *, MicroRNA-Targeted Signaling Pathways in the Autism Spectrum Disorder: Implications for Early Detection and Targeted Therapy, CNS & Neurological Disorders - Drug Targets 2021; 20 (1) . https://dx.doi.org/10.2174/1871527319666200907123315