Nanostructured Lipid Carriers (NLCs): Nose-to-Brain Delivery and Theranostic Application

Title:Nanostructured Lipid Carriers (NLCs): Nose-to-Brain Delivery and Theranostic Application

Volume: 21 Issue: 14

Author(s): Javed Ahmad*, Md. Rizwanullah, Saima Amin, Musarrat Husain Warsi, Mohammad Zaki Ahmad and Md. Abul Barkat

Affiliation:

• Department of Pharmaceutics, College of Pharmacy, Najran University, Najran,Saudi Arabia

Keywords: Nanostructured lipid carriers, colloidal dispersion, nose-to-brain delivery, theranostic, neurological disorders, targeting efficiency.

Abstract: Background: Nanostructured lipid carriers (NLCs) are in high demand in the existing pharmaceutical domain due to its high versatility. It is the newer generation of lipid nanoparticulate systems having a solid matrix and greater stability at room temperature.

Objective: To review the evidence related to the current state of the art of the NLCs system and its drug delivery perspectives to the brain.

Methods: Scientific data search, review of the current state of the art and drug delivery perspectives to the brain for NLCs were undertaken to assess the applicability of NLCs in the management of neurological disorders through an intranasal route of drug administration.

Results: NLCs are designed to fulfill all the industrial needs like simple technology, low cost, scalability, and quantifications. Biodegradable and biocompatible lipids and surfactants used for NLCs have rendered them acceptable from regulatory perspectives as well. Apart from these, NLCs have unique properties of high drug payload, modulation of drug release profile, minimum drug expulsion during storage, and incorporation in various dosage forms like gel, creams, granules, pellets, powders for reconstitution and colloidal dispersion. Ease of surface- modification of NLCs enhances targeting efficiency and reduces systemic toxicity by providing site-specific delivery to the brain through the intranasal route of drug administration.

Conclusion: The present review encompasses the in-depth discussion over the current state of the art of NLCs, nose-to-brain drug delivery perspectives, and its theranostic application as useful tools for better management of various neurological disorders. Further, pharmacokinetic consideration and toxicity concern is also discussed specifically for the NLCs system exploited in nose-to-brain delivery.

Cite this article as:

Ahmad Javed *, Rizwanullah Md. , Amin Saima , Warsi Husain Musarrat , Ahmad Zaki Mohammad and Barkat Abul Md., Nanostructured Lipid Carriers (NLCs): Nose-to-Brain Delivery and Theranostic Application, Current Drug Metabolism 2020; 21 (14) . https://dx.doi.org/10.2174/1389200221666200719003304

DOI https://dx.doi.org/10.2174/1389200221666200719003304	Print ISSN 1389-2002
Publisher Name Bentham Science Publisher	Online ISSN 1875-5453