The Regulation of E3 Ubiquitin Ligases Cbl and its Cross-talking in Bone Homeostasis

Title:The Regulation of E3 Ubiquitin Ligases Cbl and its Cross-talking in Bone Homeostasis

Volume: 16 Issue: 6

Author(s): Xiaobin Yang, Dingjun Hao* Baorong He*

Affiliation:

• Department of Spine Surgery, Honghui Hospital, School of Medicine, Xi’an Jiaotong University, Xi'an, Shaanxi,China

• Department of Spine Surgery, Honghui Hospital, School of Medicine, Xi’an Jiaotong University, Xi'an, Shaanxi,China

Keywords: E3 ubiquitin ligases, Cbl, PI3K, Src, bone homeostasis, osteoclast.

Abstract: The E3 ubiquitin ligases Cbl has been found play an important role in regulating cellular proliferation and migration. Whereas, the excessive differentiation of osteoclast and/or its overexpressing of resorptive functions could lead the pathological bone homeostasis by overly bone matrix degradation. Since the first time of the important role of Cbl in the regulating osteoclast differentiation (also named osteoclastogenesis) has been reported in decades ago. The extensively studies have been conducted for in-depth exploring Cbl’s definite role during osteoclastogenesis, as well as its cross talking with other signaling pathways (such as: Src and PI3K signaling) in bone homeostasis. Herein, our current study aims to briefly conclude the current studies of osteoclastogenesis and the regulatory role of Cbl, as well as its cross-talking in bone homeostasis.

Cite this article as:

Yang Xiaobin , Hao Dingjun *, He Baorong *, The Regulation of E3 Ubiquitin Ligases Cbl and its Cross-talking in Bone Homeostasis, Current Stem Cell Research & Therapy 2021; 16 (6) . https://dx.doi.org/10.2174/1574888X15666200712191623