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Current Nutrition & Food Science

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ISSN (Print): 1573-4013
ISSN (Online): 2212-3881

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Research Article

Seaweed Extract Improves Carbohydrate Metabolism in Overweight and Obese Adults

Author(s): Anita S. Elidottir, Kolbrun Sveinsdottir, Bergros Ingadottir, Olof G. Geirsdottir, Palmi V. Jonsson, Elisabeth Rothenberg, Ingibjorg Hardardottir, Jona Freysdottir and Alfons Ramel*

Volume 17, Issue 2, 2021

Published on: 05 July, 2020

Page: [216 - 224] Pages: 9

DOI: 10.2174/1573401316999200706012619

Price: $65

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Abstract

Background: Obesity is characterized by chronic low-grade inflammation and associated with type 2 diabetes. Seaweed is one of the largest producers of biomass in the marine environment and is a rich arsenal of functional ingredients that may possess the potential to prevent type 2 diabetes.

Objective: The aim was to investigate the effects of seaweed extract on glucose metabolism and markers of inflammation in overweight and obese individuals.

Methods: Participants (N=76, ≥40 years, body mass index ≥25 kg/m2) who volunteered for this 10- week randomized, controlled, doubly blinded intervention study, were randomized into an intervention group (seaweed extract, 3 capsules=1200 mg/day) or a control group (placebo, 3 capsules/day). The extract derived from the brown seaweed bladder wrack (Fucus vesiculosus). At baseline and endpoint of the study, fasting samples were analysed for blood glucose, insulin, inflammation markers, liver enzymes and creatinine (renal function).

Results: Drop out was 11.8% and not significantly different between groups. Fasting blood glucose and insulin were improved at the endpoint in the intervention group, but no changes were observed in the control group (corrected endpoint differences between groups: glucose=0.61 mmol/L, P=0.038; insulin=0.72 μU/L, P=0.038). Measures of inflammation, liver enzymes and renal function did not change significantly during the study.

Conclusion: Ingestion of seaweed extract over 10 weeks improves glucose metabolism without affecting measures of inflammation, liver function or renal function.

Keywords: Blood glucose, inflammation, insulin, renal function, seaweed extract, type 2 diabetes.

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[1]
Unamuno X, Gómez-Ambrosi J, Rodríguez A, et al. Adipokine dysregulation and adipose tissue inflammation in human obesity. Eur J Clin Invest 2018; 48(9)e12997
[http://dx.doi.org/10.1111/eci.12997] [PMID: 29995306]
[2]
World Health Organization Global report on Diabetes Avaiulable from http://www.who.int
[3]
Ley SH, Hamdy O, Mohan V, et al. Prevention and management of type 2 diabetes: dietary components and nutritional strategies. Lancet 2014; 383(9933): 1999-2007.
[http://dx.doi.org/10.1016/S0140-6736(14)60613-9] [PMID: 24910231]
[4]
Zorofchian MS, Karimian H, Khanabdali R, et al. Anticancer and antitumor potential of fucoidan and fucoxanthin, two main metabolites isolated from brown algae. Scientific World Journal 2014; 2014768323
[http://dx.doi.org/10.1155/2014/768323] [PMID: 24526922]
[5]
Holdt S, Kraan S. Bioactive compounds in seaweed: functional food applications and legislation. J Appl Phycol 2011; 23: 543-97.
[http://dx.doi.org/10.1007/s10811-010-9632-5]
[6]
Kim KT, Rioux LE, Turgeon SL. Alpha-amylase and alpha-glucosidase inhibition is differentially modulated by fucoidan obtained from Fucus vesiculosus and Ascophyllum nodosum. Phytochemistry 2014; 98: 27-33.
[http://dx.doi.org/10.1016/j.phytochem.2013.12.003] [PMID: 24388677]
[7]
Lordan S, Smyth TJ, Soler-Vila A, et al. The α-amylase and α-glucosidase inhibitory effects of Irish seaweed extracts. Food Chem 2013; 141(3): 2170-6.
[http://dx.doi.org/10.1016/j.foodchem.2013.04.123] [PMID: 23870944]
[8]
Apostolidis E, Lee CM. In vitro potential of Ascophyllum nodosum phenolic antioxidant-mediated alpha-glucosidase and alpha-amylase inhibition. J Food Sci 2010; 75(3): H97-H102.
[http://dx.doi.org/10.1111/j.1750-3841.2010.01544.x] [PMID: 20492300]
[9]
Kang MC, Wijesinghe WA, Lee SH, et al. Dieckol isolated from brown seaweed Ecklonia cava attenuates type II diabetes in db/db mouse model. Food Chem Toxicol 2013; 53: 294-8.
[http://dx.doi.org/10.1016/j.fct.2012.12.012] [PMID: 23261675]
[10]
Motshakeri M, Ebrahimi M, Goh YM, et al. Sargassum polycystum reduces hyperglycaemia, dyslipidaemia and oxidative stress via increasing insulin sensitivity in a rat model of type 2 diabetes. J Sci Food Agric 2013; 93(7): 1772-8.
[http://dx.doi.org/10.1002/jsfa.5971] [PMID: 23208488]
[11]
Maeda H, Hosokawa M, Sashima T, et al. Anti-obesity and anti-diabetic effects of fucoxanthin on diet-induced obesity conditions in a murine model. Mol Med Rep 2009; 2(6): 897-902.
[http://dx.doi.org/10.3892/mmr_00000189] [PMID: 21475918]
[12]
Kim MJ, Kim HK. Insulinotrophic and hypolipidemic effects of Ecklonia cava in streptozotocin-induced diabetic mice. Asian Pac J Trop Med 2012; 5(5): 374-9.
[http://dx.doi.org/10.1016/S1995-7645(12)60062-5] [PMID: 22546654]
[13]
Lee HJ, Kim HC, Vitek L, et al. Algae consumption and risk of type 2 diabetes: Korean National Health and Nutrition Examination Survey in 2005. J Nutr Sci Vitaminol 2010; 56(1): 13-8.
[http://dx.doi.org/10.3177/jnsv.56.13] [PMID: 20354341]
[14]
Kim MS, Kim JY, Choi WH, et al. Effects of seaweed supplementation on blood glucose concentration, lipid profile, and antioxidant enzyme activities in patients with type 2 diabetes mellitus. Nutr Res Pract 2008; 2(2): 62-7.
[http://dx.doi.org/10.4162/nrp.2008.2.2.62] [PMID: 20126367]
[15]
Teas J, Baldeón ME, Chiriboga DE, et al. Could dietary seaweed reverse the metabolic syndrome? Asia Pac J Clin Nutr 2009; 18(2): 145-54.
[PMID: 19713172]
[16]
Geirsdottir OG, Arnarson A, Briem K, et al. Effect of 12-week resistance exercise program on body composition, muscle strength, physical function, and glucose metabolism in healthy, insulin-resistant, and diabetic elderly Icelanders. J Gerontol A Biol Sci Med Sci 2012; 67(11): 1259-65.
[http://dx.doi.org/10.1093/gerona/gls096] [PMID: 22496538]
[17]
World Health Organization 2018. Available from: http://www. who. int/topics/obesity/en/2018
[18]
Elidottir AS, Halldorsson TI, Gunnarsdottir I, et al. Dietary intake and cardiovascular risk factors in Icelanders following voluntarily a low carbohydrate diet. PLoS One 2016; 11(8)e0156655
[http://dx.doi.org/10.1371/journal.pone.0156655] [PMID: 27560647]
[19]
Sveinsdottir K, Martinsdottir E, Ramel A. Blood pressure-lowering effects of long chain n-3 fatty acids from meals enriched with liquid fish oil and from microencapsulated powder. Int J Food Sci Nutr 2016; 67(8): 1017-23.
[http://dx.doi.org/10.1080/09637486.2016.1208733] [PMID: 27457968]
[20]
Murugan AC, Karim MR, Yusoff MB, et al. New insights into seaweed polyphenols on glucose homeostasis. Pharm Biol 2015; 53(8): 1087-97.
[http://dx.doi.org/10.3109/13880209.2014.959615] [PMID: 25630358]
[21]
Murray M, Dordevic AL, Ryan L, et al. The impact of a single dose of a polyphenol-rich seaweed extract on postprandial glycaemic control in healthy adults: a randomised cross-over trial. Nutrients 2018; 10(3)E270
[http://dx.doi.org/10.3390/nu10030270] [PMID: 29495492]
[22]
Hall AC, Fairclough AC, Mahadevan K, et al. Ascophyllum nodosum enriched bread reduces subsequent energy intake with no effect on post-prandial glucose and cholesterol in healthy, overweight males. A pilot study. Appetite 2012; 58(1): 379-86.
[http://dx.doi.org/10.1016/j.appet.2011.11.002] [PMID: 22100188]
[23]
Lee SH, Jeon YJ. Efficacy and safety of a dieckol-rich extract (AG-dieckol) of brown algae, Ecklonia cava, in pre-diabetic individuals: a double-blind, randomized, placebo-controlled clinical trial. Food Funct 2015; 6(3): 853-8.
[http://dx.doi.org/10.1039/C4FO00940A] [PMID: 25608849]
[24]
Thorgeirsdottir H, Valgeirsdottir H, Gunnarsdottir I, et al. The diet of Icelanders 2010-2011; Dietary survey of The Icelandic Medical Directorate, the Icelandic Food and Veterinary Authority and the Unit for Nutrition Research. University of Iceland 2011.
[25]
Murray M, Dordevic AL, Cox KHM, et al. Study protocol for a double-blind randomised controlled trial investigating the impact of 12 weeks supplementation with a Fucus vesiculosus extract on cholesterol levels in adults with elevated fasting LDL cholesterol who are overweight or have obesity. BMJ Open 2018; 8(12)e022195
[http://dx.doi.org/10.1136/bmjopen-2018-022195] [PMID: 30552248]
[26]
Baldrick FR, McFadden K, Ibars M, et al. Impact of a (poly)phenol-rich extract from the brown algae Ascophyllum nodosum on DNA damage and antioxidant activity in an overweight or obese population: a randomized controlled trial. Am J Clin Nutr 2018; 108(4): 688-700.
[http://dx.doi.org/10.1093/ajcn/nqy147] [PMID: 30321272]
[27]
Unnikrishnan PS, Suthindhiran K, Jayasri MA. Inhibitory potential of Turbinaria ornata against key metabolic enzymes linked to diabetes. BioMed Res Int 2014; 2014783895
[http://dx.doi.org/10.1155/2014/783895] [PMID: 25050371]
[28]
Mizuno CS, Chittiboyina AG, Kurtz TW, et al. Type 2 diabetes and oral antihyperglycemic drugs. Curr Med Chem 2008; 15(1): 61-74.
[http://dx.doi.org/10.2174/092986708783330656] [PMID: 18220763]
[29]
Coniff RF, Shapiro JA, Seaton TB. Long-term efficacy and safety of acarbose in the treatment of obese subjects with non-insulin-dependent diabetes mellitus. Arch Intern Med 1994; 154(21): 2442-8.
[http://dx.doi.org/10.1001/archinte.1994.00420210080009] [PMID: 7979840]
[30]
Hoffmann J, Spengler M. Efficacy of 24-week monotherapy with acarbose, glibenclamide, or placebo in NIDDM patients. The Essen Study. Diabetes Care 1994; 17(6): 561-6.
[http://dx.doi.org/10.2337/diacare.17.6.561] [PMID: 8082525]
[31]
Gómez-Guzmán M, Rodríguez-Nogales A, Algieri F, et al. Potential role of seaweed polyphenols in cardiovascular-associated disorders. Mar Drugs 2018; 16(8): 250.
[http://dx.doi.org/10.3390/md16080250] [PMID: 30060542]
[32]
Panzhinskiy E, Ren J, Nair S. Protein tyrosine phosphatase 1B and insulin resistance: role of endoplasmic reticulum stress/reactive oxygen species/nuclear factor kappa B axis. PLoS One 2013; 8(10)e77228
[http://dx.doi.org/10.1371/journal.pone.0077228] [PMID: 24204775]
[33]
Eo H, Jeon YJ, Lee M, et al. Brown Alga Ecklonia cava polyphenol extract ameliorates hepatic lipogenesis, oxidative stress, and inflammation by activation of AMPK and SIRT1 in high-fat diet-induced obese mice. J Agric Food Chem 2015; 63(1): 349-59.
[http://dx.doi.org/10.1021/jf502830b] [PMID: 25479240]
[34]
Park EY, Choi H, Yoon JY, et al. Polyphenol-rich fraction of Ecklonia cava improves nonalcoholic fatty liver disease in high fat diet-fed mice. Mar Drugs 2015; 13(11): 6866-83.
[http://dx.doi.org/10.3390/md13116866] [PMID: 26569269]
[35]
Min KH, Kim HJ, Jeon YJ, et al. Ishige okamurae ameliorates hyperglycemia and insulin resistance in C57BL/KsJ-db/db mice. Diabetes Res Clin Pract 2011; 93(1): 70-6.
[http://dx.doi.org/10.1016/j.diabres.2011.03.018] [PMID: 21481483]
[36]
Lee SH, Ko SC, Kang MC, et al. Octaphlorethol A, a marine algae product, exhibits antidiabetic effects in type 2 diabetic mice by activating AMP-activated protein kinase and upregulating the expression of glucose transporter 4. Food Chem Toxicol 2016; 91: 58-64.
[http://dx.doi.org/10.1016/j.fct.2016.02.022] [PMID: 26939912]
[37]
Rocchetti G, Pagnossa JP, Blasi F, et al. Phenolic profiling and in vitro bioactivity of Moringa oleifera leaves as affected by different extraction solvents. Food Res Int 2020; 127108712
[http://dx.doi.org/10.1016/j.foodres.2019.108712] [PMID: 31882101]
[38]
Pinakin DJ, Kumar V, Suri S, et al. Nutraceutical potential of tree flowers: a comprehensive review on biochemical profile, health benefits, and utilization. Food Res Int 2020; 127108724
[http://dx.doi.org/10.1016/j.foodres.2019.108724] [PMID: 31882088]
[39]
Sardeli AV, Tomeleri CM, Cyrino ES, et al. Effect of resistance training on inflammatory markers of older adults: a meta-analysis. Exp Gerontol 2018; 111: 188-96.
[http://dx.doi.org/10.1016/j.exger.2018.07.021] [PMID: 30071283]
[40]
Shiels MS, Katki HA, Freedman ND, et al. Cigarette smoking and variations in systemic immune and inflammation markers. J Natl Cancer Inst 2014; 106(11)dju294
[http://dx.doi.org/10.1093/jnci/dju294] [PMID: 25274579]
[41]
Lorenz TK, Demas GE, Heiman JR. Partnered sexual activity moderates menstrual cycle-related changes in inflammation markers in healthy women: an exploratory observational study. Fertil Steril 2017; 107(3): 763-73.
[http://dx.doi.org/10.1016/j.fertnstert.2016.11.010] [PMID: 27919440]
[42]
Fitton JH. Therapies from fucoidan; multifunctional marine polymers. Mar Drugs 2011; 9(10): 1731-60.
[http://dx.doi.org/10.3390/md9101731] [PMID: 22072995]
[43]
Arikawa AY, O’Dougherty M, Schmitz KH. Adherence to a strength training intervention in adult women. J Phys Act Health 2011; 8(1): 111-8.
[http://dx.doi.org/10.1123/jpah.8.1.111] [PMID: 21297191]

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