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General Review Article

Characteristic of Cyclodextrins: Their Role and Use in the Pharmaceutical Technology

Author(s): Malwina Lachowicz*, Andrzej Stańczak and Michał Kołodziejczyk

Volume 21, Issue 14, 2020

Page: [1495 - 1510] Pages: 16

DOI: 10.2174/1389450121666200615150039

open access plus

Abstract

About 40% of newly-discovered entities are poorly soluble in water, and this may be an obstacle in the creation of new drugs. To address this problem, the present review article examines the structure and properties of cyclodextrins and the formation and potential uses of drug – cyclodextrin inclusion complexes. Cyclodextrins are cyclic oligosaccharides containing six or more D-(+)- glucopyranose units linked by α-1,4-glycosidic bonds, which are characterized by a favourable toxicological profile, low local toxicity and low mucous and eye irritability; they are virtually non-toxic when administered orally. They can be incorporated in the formulation of new drugs in their natural form (α-, β-, γ-cyclodextrin) or as chemically-modified derivatives. They may also be used as an excipient in drugs delivered by oral, ocular, dermal, nasal and rectal routes, as described in the present paper. Cyclodextrins are promising compounds with many beneficial properties, and their use may be increasingly profitable for pharmaceutical scientists.

Keywords: Cyclodextrin, inclusion complex, solubility, drug delivery, routes of administration, eye irritability.

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