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Current Stem Cell Research & Therapy

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ISSN (Print): 1574-888X
ISSN (Online): 2212-3946

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Review Article

Cancer Stemness as a Target for Immunotherapy is Shaped by Proinflammatory Stress

Author(s): Nese Unver*

Volume 16, Issue 7, 2021

Published on: 09 March, 2020

Page: [792 - 800] Pages: 9

DOI: 10.2174/1574888X15666200309145901

Price: $65

Abstract

Cancer stem cells represent a rare subpopulation of cancer cells carrying self-renewal and differentiation features in multi-step tumorigenesis, tumor recurrence and metastasis. Proinflammatory stress is highly associated with cancer stemness via induction of cytokines, tumorpromoting immune cells and cancer stemness-related signaling pathways. This review summarizes the major pro-inflammatory factors affecting cancer stem cell characteristics and the critical immunotherapeutic strategies to eliminate cancer stem cells.

Keywords: Inflammation, cancer stemness, pro-inflammatory stress, cancer stem cells, pro-inflammatory cytokines, immunotherapeutic strategies.

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