Cancer Stemness as a Target for Immunotherapy is Shaped by Proinflammatory Stress

Title:Cancer Stemness as a Target for Immunotherapy is Shaped by Proinflammatory Stress

Volume: 16 Issue: 7

Author(s): Nese Unver*

Affiliation:

• Department of Stem Cell Sciences, Graduate School of Health Sciences, Center for Stem Cell Research and Development, Hacettepe University, Sihhiye, 06100, Ankara,Turkey

Keywords: Inflammation, cancer stemness, pro-inflammatory stress, cancer stem cells, pro-inflammatory cytokines, immunotherapeutic strategies.

Abstract: Cancer stem cells represent a rare subpopulation of cancer cells carrying self-renewal and differentiation features in multi-step tumorigenesis, tumor recurrence and metastasis. Proinflammatory stress is highly associated with cancer stemness via induction of cytokines, tumorpromoting immune cells and cancer stemness-related signaling pathways. This review summarizes the major pro-inflammatory factors affecting cancer stem cell characteristics and the critical immunotherapeutic strategies to eliminate cancer stem cells.

Cite this article as:

Unver Nese *, Cancer Stemness as a Target for Immunotherapy is Shaped by Proinflammatory Stress, Current Stem Cell Research & Therapy 2021; 16 (7) . https://dx.doi.org/10.2174/1574888X15666200309145901