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Current Pharmaceutical Biotechnology

Editor-in-Chief

ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

Review Article

Current Prospects of Nutraceuticals: A Review

Author(s): Vedant Sachdeva, Arpita Roy and Navneeta Bharadvaja*

Volume 21, Issue 10, 2020

Page: [884 - 896] Pages: 13

DOI: 10.2174/1389201021666200130113441

Price: $65

Abstract

Nutraceuticals are dietary supplements, utilized to ameliorate health, delay senescence, prevent diseases, and support the proper functioning of the human body. Currently, nutraceuticals are gaining substantial attention due to nutrition and therapeutic potentials. Based on their sources, they are categorized as dietary supplements and herbal bioactive compounds. The global market for nutraceutical is huge i.e. approximately USD 117 billion. Herbal nutraceutical helps in maintaining health and promoting optimal health, longevity, and quality of life. Studies have shown promising results of nutraceuticals to treat several diseases, such as cancer, neurodegenerative diseases, cardiovascular diseases, etc. In the present review, an overview of various bioactive ingredients that act as nutraceuticals (carbohydrates, lipids, edible flowers, alkaloids, medicinal plants, etc.) and their role in health benefits, has been discussed. Further application of nutraceuticals in the prevention of various diseases has also been discussed.

Keywords: Nutraceutical, source, medicinal plants, cancer, application, diabetes.

Graphical Abstract

[1]
Sosnowska, B.; Penson, P.; Banach, M. The role of nutraceuticals in the prevention of cardiovascular disease. Cardiovasc. Diagn. Ther., 2017, 7(Suppl. 1), S21-S31.
[http://dx.doi.org/10.21037/cdt.2017.03.20] [PMID: 28529919]
[2]
Ashwlayan, V.; Nimesh, S. Nutraceuticals in the management of diabetes mellitus. Pharm. Pharmacol. Int. J., 2018, 6, 114-120.
[http://dx.doi.org/10.15406/ppij.2018.06.00166]
[3]
Aquila, G.; Marracino, L.; Martino, V.; Calabria, D.; Campo, G.; Caliceti, C.; Rizzo, P. the use of nutraceuticals to counteract atherosclerosis: The role of the notch pathway. Oxid. Med. Cell. Longev., 2019, 2019, 5470470.
[http://dx.doi.org/10.1155/2019/5470470] [PMID: 31915510]
[4]
McClements, D.J. Nutraceuticals: Superfoods or superfads? In: Future Foods; Copernicus, Chem; , 2019; pp. 167-201.
[5]
Sarris, J.; Byrne, G.J.; Stough, C.; Bousman, C.; Mischoulon, D.; Murphy, J.; Macdonald, P.; Adams, L.; Nazareth, S.; Oliver, G.; Cribb, L.; Savage, K.; Menon, R.; Chamoli, S.; Berk, M.; Ng, C.H. Nutraceuticals for major depressive disorder- more is not merrier: An 8-week double-blind, randomised, controlled trial. J. Affect. Disord., 2019, 245, 1007-1015.
[http://dx.doi.org/10.1016/j.jad.2018.11.092] [PMID: 30699842]
[6]
Hussain, S.A.; Panjagari, N.R.; Singh, R.R.; Patil, G.R. Potential herbs and herbal nutraceuticals: Food applications and their interactions with food components. Crit. Rev. Food Sci. Nutr., 2015, 55(1), 94-122.
[http://dx.doi.org/10.1080/10408398.2011.649148] [PMID: 24915396]
[7]
Dureja, H.; Kaushik, D.; Kumar, V. Developments in nutraceuticals. Indian J. Pharmacol., 2003, 35(6), 363-372.
[9]
Indian Nutraceuticals Market Outlook vision 2022. retrieved from http://publication.assocham.tv/data/product-file/88 Indian Nutraceutical Market Opportunities_Report_LR.pdf (Accessed August 23, 2019)
[10]
Sharma, A.; Kumar, P.; Sharma, P.; Shrivastav, B. A comparative study of regulatory registration procedure of nutraceuticals in India, Canada and Australia. Int. J. Pharm. Qual. Assur., 2013, 4(4), 61-66.
[12]
Galanakis, C.M. Nutraceutical and Functional Food Components, Effects of Innovative Processing Techniques, 1st ed.; Elsevier Inc., B.V.,; , 2017.
[13]
Slavin, J.; Carlson, J. Carbohydrates. Adv. Nutr., 2014, 5(6), 760-761.
[http://dx.doi.org/10.3945/an.114.006163] [PMID: 25398736]
[14]
Lattimer, J.M.; Haub, M.D. Effects of dietary fiber and its components on metabolic health. Nutrients, 2010, 2(12), 1266-1289.
[http://dx.doi.org/10.3390/nu2121266] [PMID: 22254008]
[15]
Hayes, M.; Carney, B.; Slater, J.; Brück, W. Mining marine shellfish wastes for bioactive molecules: Chitin and chitosan--Part A: extraction methods. Biotechnol. J., 2008, 3(7), 871-877.
[http://dx.doi.org/10.1002/biot.200700197] [PMID: 18320562]
[16]
Hayes, M.; Tiwari, B.K. Bioactive carbohydrates and peptides in foods: An overview of sources, downstream processing steps and associated bioactivities. ‎. Int. J. Mol. Sci., 2015, 16(9), 22485-22508.
[http://dx.doi.org/10.3390/ijms160922485] [PMID: 26393573]
[17]
Tomova, A.; Bukovsky, I.; Rembert, E.; Yonas, W.; Alwarith, J.; Barnard, N.D.; Kahleova, H. The effects of vegetarian and vegan diets on gut microbiota. Front. Nutr., 2019, 6, 47.
[http://dx.doi.org/10.3389/fnut.2019.00047] [PMID: 31058160]
[18]
Misurcova, L.; Ambrozova, J.; Samek, D. Seaweed lipids as nutraceuticals. Advances in food and nutrition research Academic Press,, 2011, 64 pp, 339-355.
[19]
Kumar, S.; Sharma, B.; Bhadwal, P.; Sharma, P.; Agnihotri, N. Lipids as nutraceuticals: A shift in paradigm. Therapeutic Foods; Academic Press, 2018, pp. 51-98.
[http://dx.doi.org/10.1016/B978-0-12-811517-6.00003-9]
[20]
Lonnie, M.; Hooker, E.; Brunstrom, J.M.; Corfe, B.M.; Green, M.A.; Watson, A.W.; Williams, E.A.; Stevenson, E.J.; Penson, S.; Johnstone, A.M. Protein for life: Review of optimal protein intake, sustainable dietary sources and the effect on appetite in ageing adults. Nutrients, 2018, 10(3), 360.
[http://dx.doi.org/10.3390/nu10030360] [PMID: 29547523]
[21]
Melini, F.; Melini, V.; Luziatelli, F.; Ruzzi, M. Current and forward-looking approaches to technological and nutritional improvements of gluten-free bread with legume flours: A Critical Review. Compr. Rev. Food Sci. Food Saf., 2017, 16, 1101-1122.
[http://dx.doi.org/10.1111/1541-4337.12279]
[22]
Das, L.; Bhaumik, E.; Raychaudhuri, U.; Chakraborty, R. Role of nutraceuticals in human health. J. Food Sci. Technol., 2012, 49(2), 173-183.
[http://dx.doi.org/10.1007/s13197-011-0269-4] [PMID: 23572839]
[23]
Drewnowski, A.; Dwyer, J.; King, J.C.; Weaver, C.M. A proposed nutrient density score that includes food groups and nutrients to better align with dietary guidance. Nutr. Rev., 2019, 77(6), 404-416.
[http://dx.doi.org/10.1093/nutrit/nuz002] [PMID: 31222368]
[24]
Réhault-Godbert, S.; Guyot, N.; Nys, Y. The golden egg: nutritional value, bioactivities, and emerging benefits for human health. Nutrients, 2019, 11(3), 684.
[http://dx.doi.org/10.3390/nu11030684] [PMID: 30909449]
[25]
Tapal, A.; Vegarud, G.E.; Sreedhara, A.; Kaul, T.P. Nutraceutical protein isolate from pigeon pea (Cajanus cajan) milling waste byproduct: Functional aspects and digestibility. Food Funct., 2019, 10(5), 2710-2719.
[http://dx.doi.org/10.1039/C8FO01933A] [PMID: 31032823]
[26]
Skrovankova, S. Seaweed vitamins as nutraceuticals. Advances in food and nutrition research; Academic Press, 2011, Vol. 64, pp. 357-369.
[27]
Hoang, B.V.; Lee, J.; Choi, I.J.; Kim, Y.W.; Ryu, K.W.; Kim, J. Effect of dietary vitamin C on gastric cancer risk in the Korean population. World J. Gastroenterol., 2016, 22(27), 6257-6267.
[http://dx.doi.org/10.3748/wjg.v22.i27.6257] [PMID: 27468215]
[28]
Carrasco-Gallardo, C.; Farías, G.A.; Fuentes, P.; Crespo, F.; Maccioni, R.B. Can nutraceuticals prevent Alzheimer’s disease? Potential therapeutic role of a formulation containing shilajit and complex B vitamins. Arch. Med. Res., 2012, 43(8), 699-704.
[http://dx.doi.org/10.1016/j.arcmed.2012.10.010] [PMID: 23131823]
[29]
Gatell-Tortajada, J. Oral supplementation with a nutraceutical formulation containing omega-3 fatty acids, vitamins, minerals, and antioxidants in a large series of patients with dry eye symptoms: results of a prospective study. Clin. Interv. Aging, 2016, 11, 571-578.
[http://dx.doi.org/10.2147/CIA.S98102] [PMID: 27279739]
[30]
Aghajanpour, M.; Nazer, M.R.; Obeidavi, Z.; Akbari, M.; Ezati, P.; Kor, N.M. Functional foods and their role in cancer prevention and health promotion: A comprehensive review. Am. J. Cancer Res., 2017, 7(4), 740-769.
[PMID: 28469951]
[31]
Eckburg, P.B.; Bik, E.M.; Bernstein, C.N.; Purdom, E.; Dethlefsen, L.; Sargent, M.; Gill, S.R.; Nelson, K.E.; Relman, D.A. Diversity of the human intestinal microbial flora. Science, 2005, 308(5728), 1635-1638.
[http://dx.doi.org/10.1126/science.1110591] [PMID: 15831718]
[32]
Guarner, F.; Bourdet-Sicard, R.; Brandtzaeg, P.; Gill, H.S.; McGuirk, P.; van Eden, W.; Versalovic, J.; Weinstock, J.V.; Rook, G.A. Mechanisms of disease: the hygiene hypothesis revisited. Nat. Clin. Pract. Gastroenterol. Hepatol., 2006, 3(5), 275-284.
[http://dx.doi.org/10.1038/ncpgasthep0471] [PMID: 16673007]
[33]
Kechagia, M.; Basoulis, D.; Konstantopoulou, S.; Dimitriadi, D.; Gyftopoulou, K.; Skarmoutsou, N.; Fakiri, E.M. Health benefits of probiotics: A review. ISRN Nutr., 2013, 2013, 481651.
[http://dx.doi.org/10.5402/2013/481651] [PMID: 24959545]
[34]
Markowiak, P.; Śliżewska, K. Effects of probiotics, prebiotics, and synbiotics on human health. Nutrients, 2017, 9(9), 1021.
[http://dx.doi.org/10.3390/nu9091021] [PMID: 28914794]
[35]
Tokunaga, T. Novel physiological function of fructooligosaccharides. Biofactors, 2004, 21(1-4), 89-94.
[http://dx.doi.org/10.1002/biof.552210117] [PMID: 15630176]
[36]
Forchielli, M.L.; Walker, W.A. The role of gut-associated lymphoid tissues and mucosal defence. Br. J. Nutr., 2005, 93(S1)(Suppl. 1), S41-S48.
[http://dx.doi.org/10.1079/BJN20041356] [PMID: 15877894]
[37]
Priebe, M.G.; Vonk, R.J.; Sun, X.; He, T.; Harmsen, H.J.; Welling, G.W. The physiology of colonic metabolism. Possibilities for interventions with pre- and probiotics. Eur. J. Nutr., 2002, 41(1)(Suppl. 1), I2-I10.
[http://dx.doi.org/10.1007/s00394-002-1101-8] [PMID: 12420110]
[38]
Blaut, M. Relationship of prebiotics and food to intestinal microflora. Eur. J. Nutr., 2002, 41(1)(Suppl. 1), I11-I16.
[http://dx.doi.org/10.1007/s00394-002-1102-7] [PMID: 12420111]
[39]
Slavin, J. Why whole grains are protective: Biological mechanisms. Proc. Nutr. Soc., 2003, 62(1), 129-134.
[http://dx.doi.org/10.1079/PNS2002221] [PMID: 12740067]
[40]
Rathore, H.; Prasad, S.; Sharma, S. Mushroom nutraceuticals for improved nutrition and better human health: A review. PharmaNutrition, 2017, 5(2), 35-46.
[http://dx.doi.org/10.1016/j.phanu.2017.02.001]
[41]
Aida, F.M.N.A.; Shuhaimi, M.; Yazid, M.; Maaruf, A.G. Mushroom as a potential source of prebiotics: A review. ‎. Trends Food Sci. Technol., 2009, 20(11-12), 567-575.
[http://dx.doi.org/10.1016/j.tifs.2009.07.007]
[42]
Arora, S.; Tandon, C.; Tandon, S. Evaluation of the cytotoxic effects of CAM therapies: An in vitro study in normal kidney cell lines. Sci. World J, 2014. 2014
[43]
Rahi, D.K.; Malik, D. Diversity of mushrooms and their metabolites of nutraceutical and therapeutic significance J. Mycol 2016, 2016.
[44]
Chaturvedi, V.K.; Agarwal, S.; Gupta, K.K.; Ramteke, P.W.; Singh, M.P. Medicinal mushroom: Boon for therapeutic applications 3 Biotech.,, 2018, 8(8), 334.
[45]
Badalyan, S.M.; Barkhudaryan, A.; Rapior, S. Recent progress in research on the pharmacological potential of mushrooms and prospects for their clinical application. Medicinal Mushrooms; Springer: Singapore, 2019, pp. 1-70.
[http://dx.doi.org/10.1007/978-981-13-6382-5_1]
[46]
Roy, A.; Jauhari, N.; Bharadvaja, N. Medicinal Plants as a Potential Source of Chemopreventive Agents. Anticancer Plants: Natural Products and Biotechnological Implements; Springer, 2018, pp. 109-139.
[47]
Roy, A.; Bharadvaja, N. Biotechnological approaches for the production of pharmaceutically important compound. Plumbagin. Curr. Pharm. Biotechnol., 2018, 19(5), 372-381.
[http://dx.doi.org/10.2174/1389201019666180629143842] [PMID: 29956626]
[48]
Roy, A.; Bharadvaja, N. Medicinal plants in the management of cancer: A review. Int. J. Complement. Alt. Med., 2017, 2017(9), 009291.
[49]
Roy, A.; Ahuja, S.; Bharadvaja, N. A review on medicinal plants against cancer. J. Plant Sci. Agricult. Res., 2017, 1(008)
[50]
Kapoor, V.K.; Dureja, J.; Chadha, R. Herbals in the control of ageing. Drug Discov. Today, 2009, 14(19-20), 992-998.
[http://dx.doi.org/10.1016/j.drudis.2009.06.014] [PMID: 19596462]
[51]
Srinivas, G.; Babykutty, S.; Sathiadevan, P.P.; Srinivas, P. Molecular mechanism of emodin action: Transition from laxative ingredient to an antitumor agent. Med. Res. Rev., 2007, 27(5), 591-608.
[http://dx.doi.org/10.1002/med.20095] [PMID: 17019678]
[52]
Lee, H.Z.; Hsu, S.L.; Liu, M.C.; Wu, C.H. Effects and mechanisms of aloe-emodin on cell death in human lung squamous cell carcinoma. Eur. J. Pharmacol., 2001, 431(3), 287-295.
[http://dx.doi.org/10.1016/S0014-2999(01)01467-4] [PMID: 11730720]
[53]
Yeh, F.T.; Wu, C.H.; Lee, H.Z. Signaling pathway for aloeemodin-induced apoptosis in human H460 lung nonsmall carcinoma cell. Int. J. Cancer, 2003, 106(1), 26-33.
[http://dx.doi.org/10.1002/ijc.11185] [PMID: 12794753]
[54]
Huang, Q.; Lu, G.; Shen, H.M.; Chung, M.C.; Ong, C.N. Anticancer properties of anthraquinones from rhubarb. Med. Res. Rev., 2007, 27(5), 609-630.
[http://dx.doi.org/10.1002/med.20094] [PMID: 17022020]
[55]
Elsohly, M.A.; Gul, W.; Avula, B.; Khan, I.A. Determination of the anthraquinones aloe-emodin and aloin-A by liquid chromatography with mass spectrometric and diode array detection. J. AOAC Int., 2007, 90(1), 28-42.
[PMID: 17373434]
[56]
Sottorff, I.; Künzel, S.; Wiese, J.; Lipfert, M.; Preußke, N.; Sönnichsen, F.D.; Imhoff, J.F. Antitumor anthraquinones from an easter island sea anemone: Animal or bacterial origin? Mar. Drugs, 2019, 17(3), 154.
[http://dx.doi.org/10.3390/md17030154] [PMID: 30841562]
[57]
Debnath, B.; Singh, W.S.; Das, M.; Goswami, S.; Singh, M.K.; Maiti, D.; Manna, K. Role of plant alkaloids on human health: A review of biological activities. Mater. Today Chem., 2018, 9, 56-72.
[http://dx.doi.org/10.1016/j.mtchem.2018.05.001]
[58]
Kumar, S. Alkaloidal drugs-A review. Asian J. Pharm. Sci., 2014, 4(3), 2014.
[59]
Isah, T. Anticancer alkaloids from trees: Development into drugs. Pharmacogn. Rev., 2016, 10(20), 90-99.
[http://dx.doi.org/10.4103/0973-7847.194047] [PMID: 28082790]
[60]
Alasvand, M.; Assadollahi, V.; Ambra, R.; Hedayati, E.; Kooti, W.; Peluso, I. Antiangiogenic effect of alkaloids. Oxid. Med. Cell. Longev., 2019, 2019, 9475908.
[http://dx.doi.org/10.1155/2019/9475908]
[61]
Aniszewski, T. Alkaloids-Secrets of Life: Aklaloid Chemistry, Biological Significance, Applications and Ecological Role; Elsevier, 2007.
[62]
Gorgani, L.; Mohammadi, M.; Najafpour, G.D.; Nikzad, M. Piperine-the bioactive compound of black pepper: From isolation to medicinal formulations. Compr. Rev. Food Sci. Food Saf., 2017, 16(1), 124-140.
[http://dx.doi.org/10.1111/1541-4337.12246]
[63]
Srinivasan, K. Black pepper and its pungent principle-piperine: A review of diverse physiological effects. Crit. Rev. Food Sci. Nutr., 2007, 47(8), 735-748.
[http://dx.doi.org/10.1080/10408390601062054] [PMID: 17987447]
[64]
Zsila, F.; Hazai, E.; Sawyer, L. Binding of the pepper alkaloid piperine to bovine β-lactoglobulin: Circular dichroism spectroscopy and molecular modeling study. J. Agric. Food Chem., 2005, 53(26), 10179-10185.
[http://dx.doi.org/10.1021/jf051944g] [PMID: 16366712]
[65]
Pareek, M.; Hansson, N.H.; Grove, E.L. Ventricular tachycardia induced by weight loss pills. Case Reports Med 2013, 2013.
[http://dx.doi.org/10.1155/2013/712383]
[66]
Moreira, R.; Pereira, D.M.; Valentão, P.; Andrade, P.B. Pyrrolizidine alkaloids: Chemistry, pharmacology, toxicology and food safety. Int. J. Mol. Sci., 2018, 19(6), 1668.
[http://dx.doi.org/10.3390/ijms19061668] [PMID: 29874826]
[67]
Podolak, I.; Galanty, A.; Sobolewska, D. Saponins as cytotoxic agents: A review. Phytochem. Rev., 2010, 9(3), 425-474.
[http://dx.doi.org/10.1007/s11101-010-9183-z] [PMID: 20835386]
[68]
Ding, X.; Zhang, W.; Li, S.; Yang, H. The role of cholesterol metabolism in cancer. Am. J. Cancer Res., 2019, 9(2), 219-227.
[PMID: 30906624]
[69]
Ying, W.; Sevigny, M.B.; Chen, Y.; Swanson, R.A. Poly(ADPribose) glycohydrolase mediates oxidative and excitotoxic neuronal death. Proc. Natl. Acad. Sci. USA, 2001, 98(21), 12227-12232.
[http://dx.doi.org/10.1073/pnas.211202598] [PMID: 11593040]
[70]
Bors, W.; Michel, C. Chemistry of the antioxidant effect of polyphenols. Ann. N. Y. Acad. Sci., 2002, 957(1), 57-69.
[http://dx.doi.org/10.1111/j.1749-6632.2002.tb02905.x] [PMID: 12074961]
[71]
Wei, L.; Chuncheng, Y.; Huafeng, Z.; Rugang, Y. Preparation of aloe-herbs health beverage. Food Sci. China, 2004, 25, 207-209.
[72]
Roy, A.; Bharadvaja, N. Effect of various culture conditions on shoot multiplication and GC-MS analysis of Plumbago zeylanica accessions for plumbagin production. Acta Physiol. Plant., 2018, 40(11), 190.
[http://dx.doi.org/10.1007/s11738-018-2766-9]
[73]
Roy, A.; Bharadvaja, N. Establishment of root suspension culture of Plumbago zeylanica and enhanced production of plumbagin. Ind. Crops Prod., 2019, 137, 419-427.
[http://dx.doi.org/10.1016/j.indcrop.2019.05.007]
[74]
Hoste, H.; Sotiraki, S.; Mejer, H.; Heckendorn, F.; Maurer, V.; Thamsborg, S. Alternatives to synthetic chemical antiparasitic drugs in organic livestock farming in Europe. Organic farming, prototype for sustainable agricultures; Springer: Dordrecht, 2014, pp. 149-169.
[http://dx.doi.org/10.1007/978-94-007-7927-3_8]
[75]
Links, M.R.; Taylor, J.; Kruger, M.C.; Naidoo, V.; Taylor, J.R. Kafirin microparticle encapsulated sorghum condensed tannins exhibit potential as an anti-hyperglycaemic agent in a small animal model. J. Funct. Foods, 2016, 20, 394-399.
[http://dx.doi.org/10.1016/j.jff.2015.11.015]
[76]
Brenes, A.; Roura, E. Essential oils in poultry nutrition: Main effects and modes of action. Anim. Feed Sci. Technol., 2010, 158(1-2), 1-14.
[http://dx.doi.org/10.1016/j.anifeedsci.2010.03.007]
[77]
Ozel, M.Z.; Gogus, F.; Lewis, A.C. Subcritical water extraction of essential oils from Thymbra spicata. Food Chem., 2003, 82(3), 381-386.
[http://dx.doi.org/10.1016/S0308-8146(02)00558-7]
[78]
Bansod, S.; Rai, M. Antifungal activity of essential oils from Indian medicinal plants against human pathogenic Aspergillus fumigatus and A. niger. World J. Med. Sci., 2008, 3(2), 81-88.
[79]
Christaki, E.; Bonos, E.; Giannenas, I.; Florou-Paneri, P. Aromatic plants as a source of bioactive compounds. Agriculture, 2012, 2(3), 228-243.
[http://dx.doi.org/10.3390/agriculture2030228]
[80]
Sugawara, T.; Yamashita, K.; Asai, A.; Nagao, A.; Shiraishi, T.; Imai, I.; Hirata, T. Esterification of xanthophylls by human intestinal Caco-2 cells. Arch. Biochem. Biophys., 2009, 483(2), 205-212.
[http://dx.doi.org/10.1016/j.abb.2008.10.007] [PMID: 18952044]
[81]
Okada, T.; Nakai, M.; Maeda, H.; Hosokawa, M.; Sashima, T.; Miyashita, K. Suppressive effect of neoxanthin on the differentiation of 3T3-L1 adipose cells. J. Oleo Sci., 2008, 57(6), 345-351.
[http://dx.doi.org/10.5650/jos.57.345] [PMID: 18469497]
[82]
Umeno, D.; Tobias, A.V.; Arnold, F.H. Diversifying carotenoid biosynthetic pathways by directed evolution. Microbiol. Mol. Biol. Rev., 2005, 69(1), 51-78.
[http://dx.doi.org/10.1128/MMBR.69.1.51-78.2005] [PMID: 15755953]
[83]
Jaswir, I.; Noviendri, D.; Hasrini, R.F.; Octavianti, F. Carotenoids: Sources, medicinal properties and their application in food and nutraceutical industry. J. Med. Plants Res., 2011, 5(33), 7119-7131.
[84]
Tang, G.; Russell, R.M. Carotenoids as provitamin A. Carotenoids; Birkhäuser Basel, 2009, pp. 149-172.
[http://dx.doi.org/10.1007/978-3-7643-7501-0_8]
[85]
Carrillo-Lopez, A.; Yahia, E.M.; Ramirez-Padilla, G.K. Bioconversion of carotenoids in five fruits and vegetables to vitamin A measured by retinol accumulation in rat livers. Am. J. Agric. Biol. Sci., 2010, 5(2), 215-221.
[http://dx.doi.org/10.3844/ajabssp.2010.215.221]
[86]
Yeum, K.J.; Aldini, G.; Russell, R.M.; Krinsky, N.I. Antioxidant/pro-oxidant actions of carotenoids. Carotenoids; Birkhäuser Basel, 2009, pp. 235-268.
[http://dx.doi.org/10.1007/978-3-7643-7501-0_12]
[87]
Linnewiel-Hermoni, K.; Khanin, M.; Danilenko, M.; Zango, G.; Amosi, Y.; Levy, J.; Sharoni, Y. The anti-cancer effects of carotenoids and other phytonutrients resides in their combined activity. Arch. Biochem. Biophys., 2015, 572, 28-35.
[http://dx.doi.org/10.1016/j.abb.2015.02.018] [PMID: 25711533]
[88]
Chao, P.D.L.; Hsiu, S.L.; Hou, Y.C. Flavonoids in herbs: biological fates and potential interactions with xenobiotics. Yao Wu Shi Pin Fen Xi, 2002, 10(4)
[89]
Panche, A.N.; Diwan, A.D.; Chandra, S.R. Flavonoids: An overview J. Nutr. Sci, 2016. 5e47
[http://dx.doi.org/10.1017/jns.2016.41] [PMID: 28620474]
[90]
Prasad, R.; Prasad, S.B. A review on the chemistry and biological properties of Rutin, a promising nutraceutical agent. Asian J. Pharm. Sci., 2019, 5(S1), 1-20.
[http://dx.doi.org/10.31024/ajpp.2019.5.s1.1]
[91]
Dhingra, D.; Michael, M.; Rajput, H.; Patil, R.T. Dietary fibre in foods: A review. J. Food Sci. Technol., 2012, 49(3), 255-266.
[http://dx.doi.org/10.1007/s13197-011-0365-5] [PMID: 23729846]
[92]
Liao, H.; Banbury, L.K.; Leach, D.N. Antioxidant activity of 45 Chinese herbs and the relationship with their TCM characteristics. Evid. Based Complement. Alternat. Med., 2008, 5(4), 429-434.
[http://dx.doi.org/10.1093/ecam/nem054] [PMID: 18955214]
[93]
McMullen, M.K.; Whitehouse, J.M.; Towell, A. Bitters: Time for a new paradigm. Evid. Based Complement. Alternat. Med., 2015, 2015670504
[94]
Manohar, S.R.; Paul, R.; Priya, S. A Brief review of synonyms and properties of Guduci (Tinospora cordifolia (Thunb.) Miers) from selected nighantus (ayurvedic drug lexicons). phcog. j., 2018, 10(6s)
[95]
Mlcek, J.; Rop, O. Fresh edible flowers of ornamental plants-A new source of nutraceutical foods. Trends Food Sci. Technol., 2011, 22(10), 561-569.
[http://dx.doi.org/10.1016/j.tifs.2011.04.006]
[96]
Fernandes, L.; Casal, S.; Pereira, J.A.; Saraiva, J.A.; Ramalhosa, E. Edible flowers: A review of the nutritional, antioxidant, antimicrobial properties and effects on human health. J. Food Compos. Anal., 2017, 60, 38-50.
[http://dx.doi.org/10.1016/j.jfca.2017.03.017]
[97]
Vaudo, A.D.; Patch, H.M.; Mortensen, D.A.; Tooker, J.F.; Grozinger, C.M. Macronutrient ratios in pollen shape bumble bee (Bombus impatiens) foraging strategies and floral preferences. Proc. Natl. Acad. Sci. USA, 2016, 113(28), E4035-E4042.
[http://dx.doi.org/10.1073/pnas.1606101113] [PMID: 27357683]
[98]
Choi, E.M.; Hwang, J.K. Investigations of anti-inflammatory and antinociceptive activities of Piper cubeba, Physalis angulata and Rosa hybrida. J. Ethnopharmacol., 2003, 89(1), 171-175.
[http://dx.doi.org/10.1016/S0378-8741(03)00280-0] [PMID: 14522451]
[99]
Obi, R.K.; Shenge, J.A. In vitro antiviral activities of Bryophyllum pinnatum (Odaa opuo) and Viscum album (Awuruse). Res. J. Microbiol., 2018, 13, 138-146.
[http://dx.doi.org/10.3923/jm.2018.138.146]
[100]
Moreno, A.; Nuño, G.; Cuello, S.; Sayago, J.E.; Alberto, M.R.; Zampini, C.; Isla, M.I. Anti-inflammatory, antioxidant and antimicrobial activity characterization and toxicity studies of flowers of “Jarilla”, a medicinal shrub from Argentina. Nat. Prod. Commun., 2015, 10(6), 991-994.
[http://dx.doi.org/10.1177/1934578X1501000648] [PMID: 26197533]
[101]
Bradbury, K.E.; Appleby, P.N.; Key, T.J. Fruit, vegetable, and fiber intake in relation to cancer risk: Findings from the European Prospective Investigation into Cancer and Nutrition (EPIC). Am. J. Clin. Nutr, 2014, 100(suppl_1), 394s-398s.
[102]
Rafieian-Kopaei, M. Medicinal plants and the human needs. J. Herbmed. Pharmacol., 2012, 1(1), 1-2.
[103]
Asgary, S.; Sahebkar, A.; Afshani, M.R.; Keshvari, M.; Haghjooyjavanmard, S.; Rafieian-Kopaei, M. Clinical evaluation of blood pressure lowering, endothelial function improving, hypolipidemic and anti-inflammatory effects of pomegranate juice in hypertensive subjects. Phytother. Res., 2014, 28(2), 193-199.
[http://dx.doi.org/10.1002/ptr.4977] [PMID: 23519910]
[104]
Nasri, H.; Baradaran, A.; Shirzad, H.; Rafieian-Kopaei, M. New concepts in nutraceuticals as alternative for pharmaceuticals. Int. J. Prev. Med., 2014, 5(12), 1487-1499.
[PMID: 25709784]
[105]
Gürbüz, P.; Martinez, A.; Pérez, C.; Martínez-González, L.; Göger, F.; Ayran, İ. Potential anti-Alzheimer effects of selected Lamiaceae plants through polypharmacology on glycogen synthase kinase-3β, β-secretase, and casein kinase 1δ. Ind. Crops Prod., 2019.138111431
[http://dx.doi.org/10.1016/j.indcrop.2019.05.080]
[106]
Park, H.J.; Jung, I.H.; Kwon, H.; Yu, J.; Jo, E.; Kim, H.; Park, S.J.; Lee, Y.C.; Kim, D.H.; Ryu, J.H. The ethanol extract of Zizyphus jujuba var. spinosa seeds ameliorates the memory deficits in Alzheimer’s disease model mice. J. Ethnopharmacol., 2019, 233, 73-79.
[http://dx.doi.org/10.1016/j.jep.2018.12.043] [PMID: 30605739]
[107]
Willis, M.S.; Wians, F.H., Jr The role of nutrition in preventing prostate cancer: A review of the proposed mechanism of action of various dietary substances. Clin. Chim. Acta, 2003, 330(1-2), 57-83.
[http://dx.doi.org/10.1016/S0009-8981(03)00048-2] [PMID: 12636926]
[108]
Shirzad, M.; Kordyazdi, R.; Shahinfard, N.; Nikokar, M. Does Royal jelly affect tumor cells? J. Herbmed. Pharmacol., 2013, 2(2), 45-48.
[109]
de Freitas, Junior; L.M de Almeida, E.B., Jr Medicinal plants for the treatment of obesity: Ethnopharmacological approach and chemical and biological studies. Am. J. Transl. Res., 2017, 9(5), 2050-2064.
[110]
Gonzalez-Suarez, I.; Martin, F.; Hoeng, J.; Peitsch, M.C. Mechanistic network models in safety and toxicity evaluation of nutraceuticals.In Nutraceuticals. ; Academic Press, 2016, pp. 287-304.
[111]
Banerjee, S.K.; Mukherjee, P.K.; Maulik, S.K. Garlic as an antioxidant: The good, the bad and the ugly. Phytother. Res., 2003, 17(2), 97-106.
[http://dx.doi.org/10.1002/ptr.1281] [PMID: 12601669]
[112]
Ali, M.; Thomson, M.; Afzal, M. Garlic and onions: Their effect on eicosanoid metabolism and its clinical relevance. Prostaglandins Leukot. Essent. Fatty Acids, 2000, 62(2), 55-73.
[http://dx.doi.org/10.1054/plef.1999.0124] [PMID: 10780871]
[115]
Chauhan, B.; Kumar, G.; Kalam, N.; Ansari, S.H. Current concepts and prospects of herbal nutraceutical: A review. J. Adv. Pharm. Technol. Res., 2013, 4(1), 4-8.
[http://dx.doi.org/10.4103/2231-4040.107494] [PMID: 23662276]
[118]
Douglas, L.C.; Sanders, M.E. Probiotics and prebiotics in dietetics practice. J. Am. Diet. Assoc., 2008, 108(3), 510-521.
[http://dx.doi.org/10.1016/j.jada.2007.12.009] [PMID: 18313433]
[119]
Santos-Zea, L.; Maria Leal-Diaz, A.; Cortés-Ceballos, E.; Alejandra Gutierrez-Uribe, J. Agave (Agave spp.) and its traditional products as a source of bioactive compounds. Curr. Bioact. Compd., 2012, 8(3), 218-231.
[http://dx.doi.org/10.2174/157340712802762410]
[120]
Bhagyalakshmi, N.; Thimmaraju, R.; Venkatachalam, L.; Murthy, K.N.; Sreedhar, R.V. Nutraceutical applications of garlic and the intervention of biotechnology. Crit. Rev. Food Sci. Nutr., 2005, 45(7-8), 607-621.
[http://dx.doi.org/10.1080/10408390500455508] [PMID: 16371330]
[121]
Upadhyay, R.K. Nutraceutical, therapeutic, and pharmaceutical potential of Aloe vera: A review Int. J. Green Pharm,, 2018, 12(01)
[122]
Triantafyllidi, A.; Xanthos, T.; Papalois, A.; Triantafillidis, J.K. Herbal and plant therapy in patients with inflammatory bowel disease. Ann. Gastroenterol., 2015, 28(2), 210-220.
[PMID: 25830661]
[123]
Kim, J.S.; Ahn, J.; Lee, S.J.; Moon, B.; Ha, T.Y.; Kim, S. Phytochemicals and antioxidant activity of fruits and leaves of paprika (Capsicum Annuum L., var. special) cultivated in Korea. J. Food Sci., 2011, 76(2), C193-C198.
[http://dx.doi.org/10.1111/j.1750-3841.2010.01891.x] [PMID: 21535734]
[124]
Witter, S.; Witter, R.; Vilu, R.; Samoson, A. Medical plants and nutraceuticals for amyloid-β fibrillation inhibition. J Alzheimers Dis. Rep., 2018, 2(1), 239-252.
[http://dx.doi.org/10.3233/ADR-180066] [PMID: 30599045]
[125]
Kunnumakkara, A.B.; Bordoloi, D.; Padmavathi, G.; Monisha, J.; Roy, N.K.; Prasad, S.; Aggarwal, B.B. Curcumin, the golden nutraceutical: Multitargeting for multiple chronic diseases. Br. J. Pharmacol., 2017, 174(11), 1325-1348.
[http://dx.doi.org/10.1111/bph.13621] [PMID: 27638428]
[126]
Bhatia, A.; Bharti, S.K.; Tripathi, T.; Mishra, A.; Sidhu, O.P.; Roy, R.; Nautiyal, C.S. Metabolic profiling of Commiphora wightii (guggul) reveals a potential source for pharmaceuticals and nutraceuticals. Phytochemistry, 2015, 110, 29-36.
[http://dx.doi.org/10.1016/j.phytochem.2014.12.016] [PMID: 25561401]
[127]
Pellati, F.; Benvenuti, S.; Magro, L.; Melegari, M.; Soragni, F. Analysis of phenolic compounds and radical scavenging activity of Echinacea spp. J. Pharm. Biomed. Anal., 2004, 35(2), 289-301.
[http://dx.doi.org/10.1016/S0731-7085(03)00645-9] [PMID: 15063463]
[128]
Badgujar, S.B.; Patel, V.V.; Bandivdekar, A.H. Foeniculum vulgare Mill: A review of its botany, phytochemistry, pharmacology, contemporary application, and toxicology. Biomed. Res. Int., 2014, 2014.
[129]
Baek, J.Y.; Lee, J.M.; Lee, S.C. Extraction of nutraceutical compounds from licorice roots with subcritical water. Separ. Purif. Tech., 2008, 63(3), 661-664.
[http://dx.doi.org/10.1016/j.seppur.2008.07.005]
[130]
Kou, X.; Li, B.; Olayanju, J.B.; Drake, J.M.; Chen, N. Nutraceutical or pharmacological potential of Moringa oleifera Lam. Nutrients, 2018, 10(3), 343.
[http://dx.doi.org/10.3390/nu10030343] [PMID: 29534518]
[131]
Mukhtar, H.; Qureshi, A.S.; Anwar, F.; Mumtaz, M.W.; Marcu, M. Nigella sativa L. seed and seed oil: Potential sources of high-value components for development of functional foods and nutraceuticals/pharmaceuticals. J. Essent. Oil Res., 2019, 31(3), 171-183.
[http://dx.doi.org/10.1080/10412905.2018.1562388]
[132]
Neale, C.; Camfield, D.; Reay, J.; Stough, C.; Scholey, A. Cognitive effects of two nutraceuticals Ginseng and Bacopa benchmarked against modafinil: A review and comparison of effect sizes. Br. J. Clin. Pharmacol., 2013, 75(3), 728-737.
[http://dx.doi.org/10.1111/bcp.12002] [PMID: 23043278]
[133]
Moreno, S.; Ojeda Sana, A.M.; Gaya, M.; Barni, M.V.; Castro, O.A.; van Baren, C. Rosemary compounds as nutraceutical health products. Food additives; InTech, 2012, pp. 157-174.
[134]
Nashine, S dege.; Kanodia, R.; Nesburn, A.B.; Soman, G.; Kuppermann, B.D.; Kenney, M.C. Nutraceutical effects of Emblica officinalis in age-related macular neration. Aging (Albany NY), 2019, 11(4), 1177-1188.
[http://dx.doi.org/10.18632/aging.101820] [PMID: 30792375]
[135]
Wani, S.A.; Kumar, P. Fenugreek: A review on its nutraceutical properties and utilization in various food products. J. Saudi Soc. Agric. Sci., 2018, 17(2), 97-106.
[http://dx.doi.org/10.1016/j.jssas.2016.01.007]
[136]
Motawi, T.K.; Hamed, M.A.; Shabana, M.H.; Hashem, R.M.; Aboul Naser, A.F. Zingiber officinale acts as a nutraceutical agent against liver fibrosis. Nutr. Metab. (Lond.), 2011, 8(1), 40.
[http://dx.doi.org/10.1186/1743-7075-8-40] [PMID: 21689445]

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