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Endocrine, Metabolic & Immune Disorders - Drug Targets

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ISSN (Online): 2212-3873

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Research Article

Plasma Cytokine Levels in Overweight Versus Obese Disease-Free Perimenopausal Women

Author(s): Anna C.B.N. Maniçoba, Leonardo V. Galvão-Moreira, Izabella M.S.C. D'Albuquerque, Haissa O. Brito, Johnny R. do Nascimento, Flávia R.F. do Nascimento, Maria do C.L. Barbosa, Rui M.G. da Costa, Maria do D.S.B. Nascimento, Manuel dos S. Faria and Luciane M.O. Brito*

Volume 20, Issue 6, 2020

Page: [917 - 923] Pages: 7

DOI: 10.2174/1871530320666191220110503

Price: $65

Abstract

Objective: To evaluate the plasma cytokine levels during T cell-mediated inflammatory responses and compare the metabolic markers between overweight and obese perimenopausal women without systemic diseases.

Methods: Sixty perimenopausal women were divided into two groups (overweight and obese). Participants in both groups had their waist-to-height ratio (WHtR) measured and blood samples collected for the evaluation of estradiol, fasting glucose, leptin, high-sensitivity C-reactive protein (hs-CRP), interleukin (IL)-6, IL-10, IL-17A levels, and lipid profile.

Results: In univariate analysis, women with obesity showed increased WHtR, fasting glucose, leptin, and IL-6 (p < 0.05) levels; however, significant differences were not observed in IL-10 or IL-17A (p > 0.05) levels. In the receiver operating characteristic curve, the highest areas under the curve were shown for leptin (0.856) and IL-6 (0.706). IL-6 levels correlated with both hs-CRP (r = 0.302, p = 0.020) and leptin (r = 0.294, p = 0.022). However, in multivariate analysis, IL-6 was not associated with a greater likelihood of obesity (OR = 1.61; 95% CI: 0.82-3.15; p = 0.16), when potential confounders were considered.

Conclusion: IL-6 levels varied between overweight and obese perimenopausal women, and this association was weaker when adjusted for other clinical variables.

Keywords: Menopause, obesity, inflammation, biomarkers, cytokines, leptin.

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