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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

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Review Article

Cellular and Molecular Mechanisms of Antithrombogenic Plants: A Narrative Review

Author(s): Tatiane C. Mendes, Francislaine Aparecida dos Reis Lívero, Priscila de Souza, Karimi S. Gebara and Arquimedes Gasparotto Junior*

Volume 26, Issue 1, 2020

Page: [176 - 190] Pages: 15

DOI: 10.2174/1381612825666191216125135

Price: $65

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Abstract

Heart attack, stroke, and deep vein thrombosis are among the conditions that alter blood coagulation and are modulated by antithrombogenic drugs. Natural products are an important source of antithrombogenic agents and have been considered remarkable alternatives with greater efficacy and usually with fewer side effects. However, the efficacy and toxicity of many of these plants that are used in traditional medicine must be scientifically tested. Despite a large number of published articles that report that plants or plant-derived components may act as antithrombogenic agents, few studies have investigated the mechanism of action of medicinal plants. This review presents the current knowledge about the major cellular and molecular mechanisms of antithrombogenic plants and their main components. Many well-established mechanisms (e.g., platelet aggregation, coagulation factors, and thrombolysis) are related to the antithrombogenic activity of many natural products. However, the central pathways that are responsible for their activity remain unclear. Further studies are needed to clarify the central role of each of these pathways in the pleiotropic response to these agents.

Keywords: Alternative therapy, anticoagulant, antiplatelet, herbal medicine, thrombolytic, antithrombogenic.

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[1]
Gale AJ. Continuing education course #2: current understanding of hemostasis. Toxicol Pathol 2011; 39(1): 273-80.
[http://dx.doi.org/10.1177/0192623310389474] [PMID: 21119054]
[2]
Bertina RM. The role of procoagulants and anticoagulants in the development of venous thromboembolism. Thromb Res 2009; 123(4): S41-5.
[http://dx.doi.org/10.1016/S0049-3848(09)70142-2]
[3]
Lyaker MR, Tulman DB, Dimitrova GT, Pin RH, Papadimos TJ. Arterial embolism. Int J Crit Illn Inj Sci 2013; 3(1): 77-87.
[http://dx.doi.org/10.4103/2229-5151.109429] [PMID: 23724391]
[4]
Abdol Razak NB, Jones G, Bhandari M, Berndt MC, Metharom P. Cancer-associated thrombosis: an overview of mechanisms, risk factors, and treatment. Cancers (Basel) 2018; 10(10): 380-401.
[http://dx.doi.org/10.3390/cancers10100380] [PMID: 30314362]
[5]
Rosendaal FR, Raskob GE. On world thrombosis day. Lancet 2014; 384: 1653-4.
[http://dx.doi.org/10.1016/S0140-6736(14)61652-4]
[6]
Bates ER, Mukherjee D, Lau WC. Drug-drug interactions involving antiplatelet agents. Eur Heart J 2003; 24(19): 1707-9.
[http://dx.doi.org/10.1016/S0195-668X(03)00470-6] [PMID: 14522564]
[7]
Angiolillo DJ. Variability in responsiveness to oral antiplatelet therapy. Am J Cardiol 2009; 103(3)(Suppl.): 27A-34.
[http://dx.doi.org/10.1016/j.amjcard.2008.11.020] [PMID: 19166710]
[8]
Memariani Z, Moeini R, Hamedi SS, Gorji N, Mozaffarpur SA. Medicinal plants with antithrombotic property in persian medicine: a mechanistic review. J Thromb Thrombolysis 2018; 45(1): 158-79.
[http://dx.doi.org/10.1007/s11239-017-1580-3] [PMID: 29124622]
[9]
Cordier W, Steenkamp V. Herbal remedies affecting coagulation: a review. Pharm Biol 2012; 50(4): 443-52.
[http://dx.doi.org/10.3109/13880209.2011.611145] [PMID: 22136282]
[10]
Yang M, Huo X, Miao Z, Wang Y. Platelet glycoprotein IIb/IIIa receptor inhibitor tirofiban in acute ischemic stroke. Drugs 2019; 79(5): 515-29.
[http://dx.doi.org/10.1007/s40265-019-01078-0] [PMID: 30838514]
[11]
Mesitskaya DF, Syrkin AL, Aksenova MG, Zhang Y, Zamyatnin AA Jr, Kopylov PY. Thromboxane a synthase: a new target for the treatment of cardiovascular diseases. Cardiovasc Hematol Agents Med Chem 2018; 16(2): 81-7.
[http://dx.doi.org/10.2174/1871525716666180724115132] [PMID: 30039765]
[12]
Mawhin MA, Tilly P, Fabre JE. The receptor EP3 to PGE2: a rational target to prevent atherothrombosis without inducing bleeding. Prostaglandins Other Lipid Mediat 2015; 121(Pt. A): 4-16.
[http://dx.doi.org/10.1016/j.prostaglandins.2015.10.001] [PMID: 26463849]
[13]
Osman A, Hitzler WE, Provost P. The platelets’ perspective to pathogen reduction technologies. Platelets 2018; 29(2): 140-7.
[http://dx.doi.org/10.1080/09537104.2017.1293806] [PMID: 28355122]
[14]
Sandberg H, Bode AP, Dombrose FA, Hoechli M, Lentz BR. Expression of coagulant activity in human platelets: release of membranous vesicles providing platelet factor 1 and platelet factor 3. Thromb Res 1985; 39(1): 63-79.
[http://dx.doi.org/10.1016/0049-3848(85)90122-7] [PMID: 3839944]
[15]
Son DJ, Cho MR, Jin YR, et al. Antiplatelet effect of green tea catechins: a possible mechanism through arachidonic acid pathway. Prostaglandins Leukot Essent Fatty Acids 2004; 71(1): 25-31.
[http://dx.doi.org/10.1016/j.plefa.2003.12.004] [PMID: 15172681]
[16]
Yamamoto J, Yamada K, Naemura A, Yamashita T, Arai R. Testing various herbs for antithrombotic effect. Nutrition 2005; 21(5): 580-7.
[http://dx.doi.org/10.1016/j.nut.2004.09.016] [PMID: 15850964]
[17]
Tohti I, Tursun M, Umar A, Turdi S, Imin H, Moore N. Aqueous extracts of Ocimum basilicum L. (sweet basil) decrease platelet aggregation induced by ADP and thrombin in vitro and rats arterio-venous shunt thrombosis in vivo. Thromb Res 2006; 118(6): 733-9.
[http://dx.doi.org/10.1016/j.thromres.2005.12.011] [PMID: 16469363]
[18]
Satake T, Kamiya K, An Y, Oishi Nee Taka T, Yamamoto J. The anti-thrombotic active constituents from Centella asiatica. Biol Pharm Bull 2007; 30(5): 935-40.
[http://dx.doi.org/10.1248/bpb.30.935] [PMID: 17473438]
[19]
Tognolini M, Ballabeni V, Bertoni S, Bruni R, Impicciatore M, Barocelli E. Protective effect of Foeniculum vulgare essential oil and anethole in an experimental model of thrombosis. Pharmacol Res 2007; 56(3): 254-60.
[http://dx.doi.org/10.1016/j.phrs.2007.07.002] [PMID: 17709257]
[20]
Yazdanparast R, Shahriyary L. Comparative effects of Artemisia dracunculus, Satureja hortensis and Origanum majorana on inhibition of blood platelet adhesion, aggregation and secretion. Vascul Pharmacol 2008; 48(1): 32-7.
[http://dx.doi.org/10.1016/j.vph.2007.11.003] [PMID: 18069068]
[21]
Malik N, Dhawan V, Bahl A, Kaul D. Inhibitory effects of Terminalia arjuna on platelet activation in vitro in healthy subjects and patients with coronary artery disease. Platelets 2009; 20(3): 183-90.
[http://dx.doi.org/10.1080/09537100902809004] [PMID: 19437336]
[22]
Geraghty DP, Ahuja KDK, Pittaway J, et al. In vitro antioxidant, antiplatelet and anti-inflammatory activity of Carpobrotus rossii (pigface) extract. J Ethnopharmacol 2011; 134(1): 97-103.
[http://dx.doi.org/10.1016/j.jep.2010.11.060] [PMID: 21130860]
[23]
Prakash P, Misra A, Surin WR, et al. Anti-platelet effects of curcuma oil in experimental models of myocardial ischemia-reperfusion and thrombosis. Thromb Res 2011; 127(2): 111-8.
[http://dx.doi.org/10.1016/j.thromres.2010.11.007] [PMID: 21144557]
[24]
Mesa MG, Piccinelli AL, Valiente MAA, et al. Inhibition of human platelet aggregation in vitro by standardized extract of Wendtia calycina. Rev Bras Farmacogn 2011; 21: 884-8.
[http://dx.doi.org/10.1590/S0102-695X2011005000109]
[25]
Song Y, Yang CJ, Yu K, et al. In vivo antithrombotic and antiplatelet activities of a quantified acanthopanax sessiliflorus fruit extract. Chin J Nat Med 2011; 9: 141-5.
[26]
O’Kennedy N, Crosbie L, van Lieshout M, Broom JI, Webb DJ, Duttaroy AK. Effects of antiplatelet components of tomato extract on platelet function in vitro and ex vivo: a time-course cannulation study in healthy humans. Am J Clin Nutr 2006; 84(3): 570-9.
[http://dx.doi.org/10.1093/ajcn/84.3.570] [PMID: 16960171]
[27]
Torres-Urrutia C, Guzmán L, Schmeda-Hirschmann G, et al. Antiplatelet, anticoagulant, and fibrinolytic activity in vitro of extracts from selected fruits and vegetables. Blood Coagul Fibrinolysis 2011; 22(3): 197-205.
[http://dx.doi.org/10.1097/MBC.0b013e328343f7da] [PMID: 21311321]
[28]
Fuentes EJ, Astudillo LA, Gutiérrez MI, et al. Fractions of aqueous and methanolic extracts from tomato (Solanum lycopersicum L.) present platelet antiaggregant activity. Blood Coagul Fibrinolysis 2012; 23(2): 109-17.
[http://dx.doi.org/10.1097/MBC.0b013e32834d78dd] [PMID: 22185934]
[29]
Klafke JZ, Arnoldi da Silva M, Fortes Rossato M, et al. Antiplatelet, antithrombotic, and fibrinolytic activities of campomanesia xanthocarpa. Evid Based Complement Alternat Med 2012; 2012 954748
[http://dx.doi.org/10.1155/2012/954748] [PMID: 21915188]
[30]
Stylos E, Chatziathanasiadou MV, Tsiailanis A, et al. Tailoring naringenin conjugates with amplified and triple antiplatelet activity profile: rational design, synthesis, human plasma stability and in vitro evaluation. Biochim Biophys Acta, Gen Subj 2017; 1861(11 Pt. A): 2609-18.
[http://dx.doi.org/10.1016/j.bbagen.2017.08.018] [PMID: 28844979]
[31]
Kang WS, Chung KH, Chung JH, et al. Antiplatelet activity of green tea catechins is mediated by inhibition of cytoplasmic calcium increase. J Cardiovasc Pharmacol 2001; 38(6): 875-84.
[http://dx.doi.org/10.1097/00005344-200112000-00009] [PMID: 11707691]
[32]
Rahman K, Lowe GM. Garlic and cardiovascular disease: a critical review. J Nutr 2006; 136(3)(Suppl.): 736S-40.
[http://dx.doi.org/10.1093/jn/136.3.736S] [PMID: 16484553]
[33]
Khatua TN, Adela R, Banerjee SK. Garlic and cardioprotection: insights into the molecular mechanisms. Can J Physiol Pharmacol 2013; 91(6): 448-58.
[http://dx.doi.org/10.1139/cjpp-2012-0315] [PMID: 23746107]
[34]
Fu J, Zhu X, Wang W, et al. 1, 6-di-O-caffeoyl-β-D-glucopyranoside, a natural compound from callicarpa nudiflora hook impairs P2Y12 and thromboxane A2 receptor-mediated amplification of platelet activation and aggregation. Phytomedicine 2017; 36: 273-82.
[http://dx.doi.org/10.1016/j.phymed.2017.10.012] [PMID: 29157825]
[35]
Meshkini A, Tahmasbi M. Antiplatelet aggregation activity of walnut hull extract via suppression of ROS generation and caspase activation. J Acupunct Meridian Stud 2017; 10: 193-203.
[http://dx.doi.org/10.1016/j.jams.2017.02.007] [PMID: 28712479]
[36]
Yang B, Zhu JP, Rong L, et al. Triterpenoids with antiplatelet aggregation activity from Ilex rotunda. Phytochemistry 2018; 145: 179-86.
[http://dx.doi.org/10.1016/j.phytochem.2017.11.005] [PMID: 29169092]
[37]
Gavriil L, Detopoulou M, Petsini F, Antonopoulou S, Fragopoulou E. Consumption of plant extract supplement reduces platelet activating factor-induced platelet aggregation and increases platelet activating factor catabolism: a randomised, double-blind and placebo-controlled trial. Br J Nutr 2019; 121(9): 982-91.
[http://dx.doi.org/10.1017/S0007114519000308] [PMID: 30940217]
[38]
Li C, Tu C, Che Y, et al. Bioassay based screening for the antiplatelet aggregation quality markers of polygonum multiflorum with UPLC and chemometrics. J Pharm Biomed Anal 2019; 166: 264-72.
[http://dx.doi.org/10.1016/j.jpba.2019.01.005] [PMID: 30685654]
[39]
Lin S, Al-Wraikat M, Niu L, et al. Degradation enhances the anticoagulant and antiplatelet activities of polysaccharides from Lycium barbarum L. leaves. Int J Biol Macromol 2019; 133: 674-82.
[http://dx.doi.org/10.1016/j.ijbiomac.2019.04.147] [PMID: 31022485]
[40]
Mohd Nor NH, Othman F, Mohd Tohit ER, et al. In vitro antiatherothrombotic effects of extracts from Berberis vulgaris L., Teucrium polium L., and Orthosiphon stamineus Benth. Evid Based Complement Alternat Med 2019; 2019 3245836
[http://dx.doi.org/10.1155/2019/3245836] [PMID: 31001352]
[41]
Cordier W, Cromarty AD, Botha E, Steenkamp V. Effects of selected South African plant extracts on haemolysis and coagulation. Hum Exp Toxicol 2012; 31(3): 250-7.
[http://dx.doi.org/10.1177/0960327111398675] [PMID: 21296832]
[42]
Dale BJ, Chan NC, Eikelboom JW. Laboratory measurement of the direct oral anticoagulants. Br J Haematol 2016; 172(3): 315-36.
[http://dx.doi.org/10.1111/bjh.13810] [PMID: 26492202]
[43]
Pawlaczyk I, Czerchawski L, Kańska J, et al. An acidic glycoconjugate from Lythrum salicaria L. with controversial effects on haemostasis. J Ethnopharmacol 2010; 131(1): 63-9.
[http://dx.doi.org/10.1016/j.jep.2010.06.001] [PMID: 20554008]
[44]
Palta S, Saroa R, Palta A. Overview of the coagulation system. Indian J Anaesth 2014; 58(5): 515-23.
[http://dx.doi.org/10.4103/0019-5049.144643] [PMID: 25535411]
[45]
Chistokhodova N, Nguyen C, Calvino T, Kachirskaia I, Cunningham G, Howard Miles D. Antithrombin activity of medicinal plants from central Florida. J Ethnopharmacol 2002; 81(2): 277-80.
[http://dx.doi.org/10.1016/S0378-8741(02)00097-1] [PMID: 12065163]
[46]
Kee NLA, Mnonopi N, Davids H. Antithrombotic/anticoagulant and anticancer activities of selected medicinal plants from South Africa. Afr J Biotechnol 2008; 7: 217-23.
[47]
Satish A, Sairam S, Ahmed F, Urooj A. Moringa oleifera lam.: protease activity against blood coagulation cascade. Pharmacognosy Res 2012; 4(1): 44-9.
[http://dx.doi.org/10.4103/0974-8490.91034] [PMID: 22224061]
[48]
de Medeiros JM, Macedo M, Contancia JP, Nguyen C, Cunningham G, Miles DH. Antithrombin activity of medicinal plants of the Azores. J Ethnopharmacol 2000; 72(1-2): 157-65.
[http://dx.doi.org/10.1016/S0378-8741(00)00226-9] [PMID: 10967467]
[49]
Goun EA, Petrichenko VM, Solodnikov SU, et al. Anticancer and antithrombin activity of Russian plants. J Ethnopharmacol 2002; 81(3): 337-42.
[http://dx.doi.org/10.1016/S0378-8741(02)00116-2] [PMID: 12127234]
[50]
Mao W, Li H, Li Y, et al. Chemical characteristic and anticoagulant activity of the sulfated polysaccharide isolated from Monostroma latissimum (Chlorophyta). Int J Biol Macromol 2009; 44(1): 70-4.
[http://dx.doi.org/10.1016/j.ijbiomac.2008.10.003] [PMID: 19007806]
[51]
Wang J, Zhang Q, Zhang Z, Song H, Li P. Potential antioxidant and anticoagulant capacity of low molecular weight fucoidan fractions extracted from Laminaria japonica. Int J Biol Macromol 2010; 46(1): 6-12.
[http://dx.doi.org/10.1016/j.ijbiomac.2009.10.015] [PMID: 19883681]
[52]
Robert S, Baccelli C, Devel P, Dogné JM, Quetin-Leclercq J. Effects of leaf extracts from Croton zambesicus Müell. Arg. on hemostasis. J Ethnopharmacol 2010; 128(3): 641-8.
[http://dx.doi.org/10.1016/j.jep.2010.02.007] [PMID: 20219668]
[53]
Chegu K, Mounika K, Rajeswari M, et al. In vitro study of anticoagulant activity of some plant extracts. World J Pharm Pharm Sci 2018; 7: 904-13.
[54]
Zhou HY, Hong JL, Shu P, Ni YJ, Qin MJ. A new dicoumarin and anticoagulant activity from Viola yedoensis Makino. Fitoterapia 2009; 80(5): 283-5.
[http://dx.doi.org/10.1016/j.fitote.2009.03.005] [PMID: 19306914]
[55]
Lee Y-S, Kwon K-J, Kim M-S, et al. Antimicrobial, antioxidant and anticoagulation activities of Korean radish (Raphanus sativus L.) leaves. Microbiol Biotechnol Lett 2013; 41: 228-35.
[http://dx.doi.org/10.4014/kjmb.1302.02007]
[56]
Bordia A, Arora SK, Kothari LK, et al. The protective action of essential oils of onion and garlic in cholesterol-fed rabbits. Atherosclerosis 1975; 22(1): 103-9.
[http://dx.doi.org/10.1016/0021-9150(75)90071-4] [PMID: 1156467]
[57]
Setorki M, Rafieian-Kopaei M, Merikhi A, et al. Suppressive impact of anethum graveolens consumption on biochemical risk factors of atherosclerosis in hypercholesterolemic rabbits. Int J Prev Med 2013; 4(8): 889-95.
[PMID: 24049614]
[58]
Tawfik MK. Anti-aggregatory effect of boswellic acid in high-fat fed rats: involvement of redox and inflammatory cascades. Arch Med Sci 2016; 12(6): 1354-61.
[http://dx.doi.org/10.5114/aoms.2016.60675] [PMID: 27904529]
[59]
Pierre S, Crosbie L, Duttaroy AK. Inhibitory effect of aqueous extracts of some herbs on human platelet aggregation in vitro. Platelets 2005; 16(8): 469-73.
[http://dx.doi.org/10.1080/09537100500129540] [PMID: 16287614]
[60]
Ding T-B, Jian L-G, Zhao J-T, et al. Ethanol extract of Carthamus tinctorius L. shows anti-thrombosis activity in rats. Afr J Tradit Complement Altern Med 2015; 12: 120-4.
[http://dx.doi.org/10.4314/ajtcam.v12i3.15]
[61]
Marzouk B, Haloui E, Akremi N, et al. Antimicrobial and anticoagulant activities of Citrullus colocynthis Schrad. leaves from Tunisia (Medenine). Afr J Pharm Pharmacol 2012; 6: 1982-8.
[62]
Potey L, Kannao S, Kosalge S. Evaluation of coagulant and anti-coagulant activity of some spices. Am J Pharm Res 2015; 5: 169-72.
[63]
Kinugasa C, Naemura A, Hyodo K, Nakai Y, Katsuta M, Yamamoto J. Experimental antithrombotic effects of sesame seed whole grains and extracts. Blood Coagul Fibrinolysis 2011; 22(6): 526-31.
[http://dx.doi.org/10.1097/MBC.0b013e328347b085] [PMID: 21577091]
[64]
Liu J, Bai R, Liu Y, Zhang X, Kan J, Jin C. Isolation, structural characterization and bioactivities of naturally occurring polysaccharide-polyphenolic conjugates from medicinal plants-A reivew. Int J Biol Macromol 2018; 107(Pt. B): 2242-50.
[http://dx.doi.org/10.1016/j.ijbiomac.2017.10.097] [PMID: 29051102]
[65]
Yu X, Wei L-H, Zhang J-K, et al. Anthraquinones from Cassiae semen as thrombin inhibitors: in vitro and in silico studies. Phytochemistry 2019; 165 112025
[http://dx.doi.org/10.1016/j.phytochem.2019.04.018] [PMID: 31207449]
[66]
Rajput MA, Khan RA, Qazi N, et al. Effect of methanol extract of Ajwain (Trachyspermum Ammi L.) on blood coagulation in rats. J Liaquat Univ Med Health Sci 2012; 11: 105-8.
[67]
Chan K, Lo ACT, Yeung JHK, Woo KS. The effects of Danshen (Salvia miltiorrhiza) on warfarin pharmacodynamics and pharmacokinetics of warfarin enantiomers in rats. J Pharm Pharmacol 1995; 47(5): 402-6.
[http://dx.doi.org/10.1111/j.2042-7158.1995.tb05819.x] [PMID: 7494191]
[68]
Ibrahim HMA, Elkhidir RSI, Mirghani F, et al. Effect of green tea consumption on prothrombin time among healthy Sudanese volunteers. IJAR 2017; 3: 703-5.
[69]
Kluft C, Sidelmann JJ, Gram JB. Assessing safety of thrombolytic therapy. Semin Thromb Hemost 2017; 43(3): 300-10.
[PMID: 27272963]
[70]
Tan RY, Pang SC, Teh SP, et al. Comparison of alteplase and urokinase for pharmacomechanical thrombolysis of clotted hemodialysis access. J Vasc Access 2019; 20(5): 501-6.
[http://dx.doi.org/10.1177/1129729818819735] [PMID: 30585114]
[71]
Wardlaw JM, Zoppo G, Yamaguchi T, Berge E. Thrombolysis for acute ischaemic stroke. Cochrane Database Syst Rev 2003; (3): CD000213
[PMID: 12917889]
[72]
Marder VJ, Stewart D. Towards safer thrombolytic therapy. Semin Hematol 2002; 39(3): 206-16.
[http://dx.doi.org/10.1053/shem.2002.34088] [PMID: 12124683]
[73]
Rahman MA, Sultana R, Bin Emran T, et al. Effects of organic extracts of six Bangladeshi plants on in vitro thrombolysis and cytotoxicity. BMC Complement Altern Med 2013; 13: 25.
[http://dx.doi.org/10.1186/1472-6882-13-25] [PMID: 23363538]
[74]
Ali MS, Amin MR, Kamal CM, Hossain MA. In vitro antioxidant, cytotoxic, thrombolytic activities and phytochemical evaluation of methanol extract of the A. philippense L. leaves. Asian Pac J Trop Biomed 2013; 3(6): 464-9.
[http://dx.doi.org/10.1016/S2221-1691(13)60097-0] [PMID: 23730559]
[75]
Islam SM, Ahmed KhT, Manik MK, Wahid MA, Kamal CS. A comparative study of the antioxidant, antimicrobial, cytotoxic and thrombolytic potential of the fruits and leaves of Spondias dulcis. Asian Pac J Trop Biomed 2013; 3(9): 682-91.
[http://dx.doi.org/10.1016/S2221-1691(13)60139-2] [PMID: 23998007]
[76]
Emran TB, Rahman MA, Uddin MM, et al. Effects of organic extracts and their different fractions of five Bangladeshi plants on in vitro thrombolysis. BMC Complement Altern Med 2015; 15: 128.
[http://dx.doi.org/10.1186/s12906-015-0643-2] [PMID: 25902818]
[77]
Kabir MS, Mahamoud MS, Chakrabarty N, et al. Antithrombotic and cytotoxic activities of four Bangladeshi plants and PASS prediction of their isolated compounds. J Basic Clin Physiol Pharmacol 2016; 27(6): 659-66.
[http://dx.doi.org/10.1515/jbcpp-2015-0144] [PMID: 27371821]
[78]
Kabir MS, Hossain MM, Kabir MI, et al. Antioxidant, antidiarrheal, hypoglycemic and thrombolytic activities of organic and aqueous extracts of Hopea odorata leaves and in silico PASS prediction of its isolated compounds. BMC Complement Altern Med 2016; 16(1): 474.
[http://dx.doi.org/10.1186/s12906-016-1461-x] [PMID: 27871266]
[79]
Scalbert A, Johnson IT, Saltmarsh M. Polyphenols: antioxidants and beyond. Am J Clin Nutr 2005; 81(1)(Suppl.): S215-7.
[http://dx.doi.org/10.1093/ajcn/81.1.215S] [PMID: 15640483]
[80]
Chaity FR, Khatun M, Rahman MS. In vitro membrane stabilizing, thrombolytic and antioxidant potentials of Drynaria quercifolia L., a remedial plant of the Garo tribal people of Bangladesh. BMC Complement Altern Med 2016; 16: 184.
[http://dx.doi.org/10.1186/s12906-016-1170-5] [PMID: 27378075]
[81]
Ahmed F, Rahman MS. Preliminary assessment of free radical scavenging, thrombolytic and membrane stabilizing capabilities of organic fractions of Callistemon citrinus (Curtis.) skeels leaves. BMC Complement Altern Med 2016; 16: 247.
[http://dx.doi.org/10.1186/s12906-016-1239-1] [PMID: 27460997]
[82]
Al Mahmud Z, Emran TB, Qais N, Bachar SC, Sarker M, Uddin MM. Evaluation of analgesic, anti-inflammatory, thrombolytic and hepatoprotective activities of roots of Premna esculenta (Roxb). J Basic Clin Physiol Pharmacol 2016; 27(1): 63-70.
[http://dx.doi.org/10.1515/jbcpp-2015-0056] [PMID: 26457773]
[83]
Ansari P, Uddin MJ, Rahman MM, et al. Anti-inflammatory, anti-diarrheal, thrombolytic and cytotoxic activities of an ornamental medicinal plant: Persicaria orientalis. J Basic Clin Physiol Pharmacol 2017; 28(1): 51-8.
[http://dx.doi.org/10.1515/jbcpp-2016-0023] [PMID: 27487493]
[84]
Zheng S, Wang D, Meng J, et al. Studies on the lignans of Polygonum orientale. Acta Bot Sin 1997; 40: 466-9.
[85]
Li YJ, He X, Liu LN, Lan YY, Wang AM, Wang YL. [Studies on chemical constituents in herb of Polygonum orientale.]. Zhongguo Zhongyao Zazhi 2005; 30(6): 444-6.
[PMID: 15810451]
[86]
Uddin MMN, Kabir MSH, Hasan M, et al. Assessment of the antioxidant, thrombolytic, analgesic, anti-inflammatory, antidepressant and anxiolytic activities of leaf extracts and fractions of Tetracera sarmentosa (L.) Vahl. J Basic Clin Physiol Pharmacol 2018; 29(1): 81-93.
[http://dx.doi.org/10.1515/jbcpp-2016-0173] [PMID: 28981441]
[87]
Gogoi D, Ramani S, Bhartari S, Chattopadhyay P, Mukherjee AK. Characterization of active anticoagulant fraction and a fibrin(ogen)olytic serine protease from leaves of Clerodendrum colebrookianum, a traditional ethno-medicinal plant used to reduce hypertension. J Ethnopharmacol 2019; 243 112099
[http://dx.doi.org/10.1016/j.jep.2019.112099] [PMID: 31326559]
[88]
Singh KA, Nayak MK, Jagannadham MV, Dash D. Thrombolytic along with anti-platelet activity of crinumin, a protein constituent of Crinum asiaticum. Blood Cells Mol Dis 2011; 47(2): 129-32.
[http://dx.doi.org/10.1016/j.bcmd.2011.06.003] [PMID: 21742519]
[89]
Bilheiro RP, Braga AD, Filho ML, et al. The thrombolytic action of a proteolytic fraction (P1G10) from Carica candamarcensis. Thromb Res 2013; 131(4): e175-82.
[http://dx.doi.org/10.1016/j.thromres.2013.01.028] [PMID: 23473638]
[90]
Zhang HY, Liu H, Yang M, Wei SF. Antithrombotic activities of aqueous extract from Gardenia jasminoides and its main constituent. Pharm Biol 2013; 51(2): 221-5.
[http://dx.doi.org/10.3109/13880209.2012.717088] [PMID: 23116215]
[91]
Arslan R, Bektas N, Bor Z, Sener E. Evaluation of the antithrombotic effects of Crataegus monogyna and Crataegus davisii in the carrageenan-induced tail thrombosis model. Pharm Biol 2015; 53(2): 275-9.
[http://dx.doi.org/10.3109/13880209.2014.914957] [PMID: 25243870]
[92]
Xie P, Cui L, Shan Y, Kang WY. Antithrombotic effect and mechanism of radix Paeoniae Rubra. BioMed Res Int 2017; 2017 9475074
[http://dx.doi.org/10.1155/2017/9475074] [PMID: 28299338]
[93]
Xie P, Zhang Y, Wang X, Wei J, Kang W. Antithrombotic effect and mechanism of Rubus spp. Blackberry Food Funct 2017; 8(5): 2000-12.
[http://dx.doi.org/10.1039/C6FO01717G] [PMID: 28485425]
[94]
Ohkura N, Atsumi G, Ohnishi K, Baba K, Taniguchi M. Possible antithrombotic effects of Angelica keiskei (Ashitaba). Pharmazie 2018; 73(6): 315-7.
[PMID: 29880082]
[95]
Chen Y, Chen PD, Bao BH, et al. Anti-thrombotic and pro-angiogenic effects of Rubia cordifolia extract in zebrafish. J Ethnopharmacol 2018; 219: 152-60.
[http://dx.doi.org/10.1016/j.jep.2017.11.005] [PMID: 29126989]

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