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Review Article

Scutellaria barbata: A Review on Chemical Constituents, Pharmacological Activities and Clinical Applications

Author(s): Qiong Chen, Khalid Rahman, Su-Juan Wang*, Shuang Zhou* and Hong Zhang*

Volume 26, Issue 1, 2020

Page: [160 - 175] Pages: 16

DOI: 10.2174/1381612825666191216124310

Price: $65

Abstract

Scutellaria barbata has a long history of medical use in Traditional Chinese Medicine for removing heat and toxic material, promoting blood circulation and removing blood stasis, and inducing diuresis to reduce edema. Recent pharmacology investigations have provided evidence for its anti-cancer, bacteriostasis, anti-virus, anti-inflammation, anti-oxidation and immunity enhancement properties. The efficacy of activating blood circulation and removing blood stasis has unique advantages in the treatment of cardiovascular and cerebrovascular diseases. A total of 84 compounds have been isolated from S. barbata and are characterized mainly as flavonoids, diterpenoids, followed by polysaccharide, volatile oil and steroids. Peer-reviewed articles published over the last few years were gathered by consulting the databases PubMed, Elsevier, Springer, and Chinese Herbal Classics. This review mainly focuses on the pharmacologically active constituents isolated from S. barbata，which have been subjected to in vitro and/or in vivo studies. Although, the chemical components, pharmacological activities, toxicology, clinical applications and mechanisms of action of S. barbata have been investigated, many constituents remain unknown. Further investigations are required to investigate the medicinal properties of S. barbata.

Keywords: Traditional Chinese Medicine, Scutellaria barbata, pharmacology, toxicology, clinical application, flavonoids.

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[1]
Shim JH, Gim H, Lee S, Kim BJ. Inductions of caspase-, MAPK- and ROS-dependent apoptosis and chemotherapeutic effects caused by an ethanol extract of Scutellaria barbata D. Don in human gastric adenocarcinom cells. J Pharmacopuncture 2016; 19(2): 129-36.
[http://dx.doi.org/10.3831/KPI.2016.19.014] [PMID: 27386146]
[2]
Shang GM, Deng YJ, Han XC. Scutellaria barbata. Capital Food Med 2015; 22(19): 51.
[3]
Peng XN, Liu YH, Liu YL, Gao JY. Advances in chemical constituents and pharmacological activities of Scutellaria barbata. Asia-Pac Trad Med 2014; 10(17): 57-8.
[4]
Liu T, Wang XY, Cao ZHQ. Advances in pharmacological action and clinical application of Scutellaria barbata. Henan Trad Chin Med 2013; 33(03): 424-6.
[5]
Dai ZJ, Wu WY, Kang HF, et al. Protective effects of Scutellaria barbata against rat liver tumorigenesis. Asian Pac J Cancer Prev 2013; 14(1): 261-5.
[http://dx.doi.org/10.7314/APJCP.2013.14.1.261] [PMID: 23534734]
[6]
Zheng X, Kang W, Liu H, Guo S. Inhibition effects of total flavonoids from Sculellaria barbata D. Don on human breast carcinoma bone metastasis via downregulating PTHrP pathway. Int J Mol Med 2018; 41(6): 3137-46.
[http://dx.doi.org/10.3892/ijmm.2018.3515] [PMID: 29512770]
[7]
Sun P, Sun D, Wang X. Effects of Scutellaria barbata polysaccharide on the proliferation, apoptosis and EMT of human colon cancer HT29 Cells. Carbohydr Polym 2017; 167: 90-6.
[http://dx.doi.org/10.1016/j.carbpol.2017.03.022] [PMID: 28433181]
[8]
Shi L, Wu Y, Lv DL, Feng L. Scutellarein selectively targets multiple myeloma cells by increasing mitochondrial superoxide production and activating intrinsic apoptosis pathway. Biomed & Pharmacother 2019; 109: 2109-18.
[http://dx.doi.org/10.1016/j.biopha.2018.09.024]
[9]
Li BJ, Wang HT, Su N. The role of blood-activating and stasis-removing drugs in the treatment of cardiovascular and cerebrovascular diseases. Chin Prac Med 2015; 8(11): 207-8.
[10]
Chen KW. The role of blood-activating and stasis-removing drugs in the treatment of cardiovascular and cerebrovascular diseases. Guid Chin Med 2010; 8(15): 42-4.
[11]
Dai ZJ, Wang BF, Lu WF, et al. Total flavonoids of Scutellaria barbata inhibit invasion of hepatocarcinoma via MMP/TIMP in vitro. Molecules 2013; 18(1): 934-50.
[http://dx.doi.org/10.3390/molecules18010934] [PMID: 23344202]
[12]
Luan LJ, Wang YF, Wu YJ. Determination of four active components in total flavonoids of Scutellaria barbata. J Zhejiang Univ [Medical Edition] 2011; 40(01): 23-6.
[13]
Chen XA, Yuan ZF, Tian YP. Determination of protocatechuic acid in Scutellaria barbata by RP-HPLC. Lishizhen Medicine and Mater Med Research 2007; (06): 1405-6.
[14]
Fu XK, Liu Y, Li Y. Simultaneous determination of coumaric acid and cinnamic acid in Scutellaria barbata by HPLC. Zhongguo Shiyan Fangjixue Zazhi 2016; 22(03): 44-7.
[15]
Liu Y, Fu XK, Li Y. Simultaneous determination of protocatechuic acid and vanillic acid in Scutellaria barbata by HPLC. Chem Anal and Meter 2015; 24(04): 20-2.
[16]
Zhong H, Liu ZP, Liu HB, Yao QQ. Determination of baicalein in Scutellaria barbata by HPLC. Food and Drugs 2008; (09): 47-8.
[17]
Jiao Y, Wang YF, Liu SL. Simultaneous determination of scutellarin and apigenin in Scutellaria barbata from different habitats by LC-MS/MS. J Pharm Anal 2009; 29(09): 1451-3.
[18]
Li P. Studies on chemical constituents of Scutellaria barbata (II). Shenyang Pharmaceutical University 2008.
[19]
Xiang RD, Zheng JF, Yao ZCH. Studies on chemical constituents of Scutellaria barbata. Chin Herb Med 1982; 13(08): 9-12.
[20]
Jiang XG, Gu ZL. Chemical constituents and pharmacological action of Scutellaria barbata. Zhongguo Yesheng Zhiwu Ziyuan 2004; (01): 3-5.
[21]
Chen LG, Hung LY, Tsai KW, et al. Wogonin, a bioactive flavonoid in herbal tea, inhibits inflammatory cyclooxygenase-2 gene expression in human lung epithelial cancer cells. Mol Nutr Food Res 2008; 52(11): 1349-57.
[http://dx.doi.org/10.1002/mnfr.200700329] [PMID: 18496814]
[22]
Li XJ. Advances in chemical constituents and anti-tumor mechanism of Scutellaria barbata.Chinese Pharmaceutical Congress and 10th Chinese Pharmacist Week. Tianjin China.
[23]
Wang YH, Xu XY, Yang SQ, Song GC. Advances in pharmacological action and chemical constituents extraction of Scutellaria Barbata. J Mudanjiang Med Univ 2017; 38(06): 116-8.
[24]
Qu GW. Discovery and antitumor activity of neo-crolane diterpenoids from Scutellaria barbata. Chinese Marine University 2012.
[25]
Wang M, Ma C, Chen Y, Li X, Chen J. Cytotoxic neoclerodane diterpenoids from Scutellaria barbata D. Don. Chem Biodivers 2018; 16(2) e1800499
[26]
Son YO, Kook SH, Lee JC. Glycoproteins and polysaccharides are the main class of active constituents required for lymphocyte stimulation and antigen-specific immune response induction by traditional medicinal herbal plants. J Med Food 2017; 20(10): 1011-21.
[http://dx.doi.org/10.1089/jmf.2017.3943] [PMID: 28816630]
[27]
Wang P. Study on anti-cancer components of Scutellaria barbata. Shandong Normal University 2010.
[28]
Xu YM, Guo LW, Chen JW. Isolation, purification and physicochemical properties of Polysaccharides from Scutellaria barbata. Res Dev Nat Prod 1992; (01): 1-5.
[29]
Lin JY, Liu SS, Ming YL. Advances in chemical constituents and pharmacological activities of Scutellaria barbata[Review]. Yaredai Zhiwu Kexue 2015; 44(01): 77-82.
[30]
Yu J, Lei J, Yu H, Cai X, Zou G. Chemical composition and antimicrobial activity of the essential oil of Scutellaria barbata. Phytochemistry 2004; 65(7): 881-4.
[http://dx.doi.org/10.1016/j.phytochem.2004.02.005] [PMID: 15081288]
[31]
Zhang FW, Hui RH, Hou DY. Analysis of volatile chemical constituents of Scutellaria barbata. J Mass Spectrom 2009; 30(3): 175-8.
[32]
Zou ZhL, Wu QN. Research progress on chemical constituents and pharmacological action of Scutellaria barbata. Lishizhen Medicine and Materia Medica Research 2005; 2: 149-50.
[33]
Bei ZHY, Luo XB, Li YB, Xia HGL. Determination of trace elements in Scutellaria barbata by microwave digestion-flame atomic absorption spectrometry. Lishizhen Medicine and Materia Medica Research 2008; 3: 709-10.
[34]
Wang Z, Yu J, Wu J, et al. Scutellarin protects cardiomyocyte ischemia-reperfusion injury by reducing apoptosis and oxidative stress. Life Sci 2016; 157: 200-7.
[http://dx.doi.org/10.1016/j.lfs.2016.01.018] [PMID: 26775564]
[35]
Guo H, Hu LM, Wang SX, et al. Neuroprotective effects of scutellarin against hypoxic-ischemic-induced cerebral injury via augmentation of antioxidant defense capacity. Chin J Physiol 2011; 54(6): 399-405.
[PMID: 22229507]
[36]
Yuan Y, Zha H, Rangarajan P, Ling EA, Wu C. Anti-inflammatory effects of Edaravone and Scutellarin in activated microglia in experimentally induced ischemia injury in rats and in BV-2 microglia. BMC Neurosci 2014; 15: 125.
[http://dx.doi.org/10.1186/s12868-014-0125-3] [PMID: 25416145]
[37]
Lee SO, Jeong YJ, Yu MH, et al. Wogonin suppresses TNF-alpha-induced MMP-9 expression by blocking the NF-kappaB activation via MAPK signaling pathways in human aortic smooth muscle cells. Biochem Biophys Res Commun 2006; 351(1): 118-25.
[http://dx.doi.org/10.1016/j.bbrc.2006.10.006] [PMID: 17052690]
[38]
Cho J, Lee H-K. Wogonin inhibits ischemic brain injury in a rat model of permanent middle cerebral artery occlusion. Biol Pharm Bull 2004; 27(10): 1561-4.
[http://dx.doi.org/10.1248/bpb.27.1561] [PMID: 15467195]
[39]
Yu LM, Dong X, Zhang J, et al. Naringenin attenuates myocardial ischemia-reperfusion injury via cGMP-PKGI signaling and in vivo and in vitro studies. Oxid Med Cell Longev 2019; 2019 7670854
[http://dx.doi.org/10.1155/2019/7670854]
[40]
Goh D, Lee YH, Ong ES. Inhibitory effects of a chemically standardized extract from Scutellaria barbata in human colon cancer cell lines, LoVo. J Agric Food Chem 2005; 53(21): 8197-204.
[http://dx.doi.org/10.1021/jf051506+] [PMID: 16218664]
[41]
Yang XK, Xu MY, Xu GS, Zhang YL, Xu ZX. In vitro and in vivo antitumor activity of scutebarbatine A on human lung carcinoma A549 cell lines. Molecules 2014; 19(7): 8740-51.
[http://dx.doi.org/10.3390/molecules19078740] [PMID: 24968330]
[42]
Yang J, Yang G, Hou G, et al. Scutellaria barbata D. Don polysaccharides inhibit the growth of Calu-3 xenograft tumors via suppression of the HER2 pathway and angiogenesis. Oncol Lett 2015; 9(6): 2721-5.
[http://dx.doi.org/10.3892/ol.2015.3127] [PMID: 26137135]
[43]
Chen CC, Kao CP, Chiu MM, Wang SH. The anti-cancer effects and mechanisms of Scutellaria barbata D. Don on CL1-5 lung cancer cells. Oncotarget 2017; 8(65): 109340-57.
[http://dx.doi.org/10.18632/oncotarget.22677] [PMID: 29312612]
[44]
Dai ZJ, Wang XJ, Li ZF, et al. Scutellaria barbate extract induces apoptosis of hepatoma H22 cells via the mitochondrial pathway involving caspase-3. World J Gastroenterol 2008; 14(48): 7321-8.
[http://dx.doi.org/10.3748/wjg.14.7321] [PMID: 19109865]
[45]
Porfyris O, Alexandrou P, Masaoutis C, Nikolakakos F. Ovarian metastasis of renal cell carcinoma: clinical and pathological presentation of a case. Turk J Urol 2018; 45(2): 150-3.
[http://dx.doi.org/10.5152/tud.2018.96237] [PMID: 30875293]
[46]
Kan X, Zhang W, You R, Niu Y, Guo J, Xue J. Scutellaria barbata D. Don extract inhibits the tumor growth through down-regulating of Treg cells and manipulating Th1/Th17 immune response in hepatoma H22-bearing mice. BMC Complement Altern Med 2017; 17(1): 41.
[http://dx.doi.org/10.1186/s12906-016-1551-9] [PMID: 28086772]
[47]
Jiang Q, Li Q, Chen H, et al. Scutellaria barbata D. Don inhibits growth and induces apoptosis by suppressing IL-6-inducible STAT3 pathway activation in human colorectal cancer cells. Exp Ther Med 2015; 10(4): 1602-8.
[http://dx.doi.org/10.3892/etm.2015.2692] [PMID: 26622533]
[48]
Jin Y, Chen W, Yang H, et al. Scutellaria barbata D. Don inhibits migration and invasion of colorectal cancer cells via suppression of PI3K/AKT and TGF-β/Smad signaling pathways. Exp Ther Med 2017; 14(6): 5527-34.
[http://dx.doi.org/10.3892/etm.2017.5242] [PMID: 29285087]
[49]
Ingham PW, Nakano Y, Seger C. Mechanisms and functions of Hedgehog signalling across the metazoa. Nat Rev Genet 2011; 12(6): 393-406.
[http://dx.doi.org/10.1038/nrg2984] [PMID: 21502959]
[50]
Hall ET, Cleverdon ER, Ogden SK. Dispatching sonic hedgehog: molecular mechanisms controlling deployment. Trends Cell Biol 2019; 29(5): 385-95.
[http://dx.doi.org/10.1016/j.tcb.2019.02.005] [PMID: 30852081]
[51]
Wei L, Lin J, Xu W, et al. Scutellaria barbata D. Don inhibits tumor angiogenesis via suppression of Hedgehog pathway in a mouse model of colorectal cancer. Int J Mol Sci 2012; 13(8): 9419-30.
[http://dx.doi.org/10.3390/ijms13089419] [PMID: 22949805]
[52]
Zhang L, Ren B, Zhang J, et al. Anti-tumor effect of Scutellaria barbata D. Don extracts on ovarian cancer and its phytochemicals characterisation. J Ethnopharmacol 2017; 206: 184-92.
[http://dx.doi.org/10.1016/j.jep.2017.05.032] [PMID: 28571726]
[53]
Kim EK, Kwon KB, Han MJ, et al. Induction of G1 arrest and apoptosis by Scutellaria barbata in the human promyelocytic leukemia HL-60 cell line. Int J Mol Med 2007; 20(1): 123-8.
[http://dx.doi.org/10.3892/ijmm.20.1.123] [PMID: 17549398]
[54]
Cha YY, Lee EO, Lee HJ, et al. Methylene chloride fraction of Scutellaria barbata induces apoptosis in human U937 leukemia cells via the mitochondrial signaling pathway. Clin Chim Acta 2004; 348(1-2): 41-8.
[http://dx.doi.org/10.1016/j.cccn.2004.04.013] [PMID: 15369734]
[55]
Marconett CN, Morgenstern TJ, San Roman AK, Sundar SN, Singhal AK, Firestone GL. BZL101, a phytochemical extract from the Scutellaria barbata plant, disrupts proliferation of human breast and prostate cancer cells through distinct mechanisms dependent on the cancer cell phenotype. Cancer Biol Ther 2010; 10(4): 397-405.
[http://dx.doi.org/10.4161/cbt.10.4.12424] [PMID: 20574166]
[56]
Wong BY, Nguyen DL, Lin T, et al. Chinese medicinal herb Scutellaria barbata modulates apoptosis and cell survival in murine and human prostate cancer cells and tumor development in TRAMP mice. Eur J Cancer Prev 2009; 18(4): 331-41.
[http://dx.doi.org/10.1097/CEJ.0b013e32832c3859] [PMID: 19444125]
[57]
Kim KW, Jin UH, Kim DI, et al. Antiproliferative effect of Scutellaria barbata D. Don. on cultured human uterine leiomyoma cells by down-regulation of the expression of Bcl-2 protein. Phytother Res 2008; 22(5): 583-90.
[http://dx.doi.org/10.1002/ptr.1996] [PMID: 18444248]
[58]
Tsai CC, Lin CS, Hsu CR, et al. Using the Chinese herb Scutellaria barbata against extensively drug-resistant Acinetobacter baumannii infections: in vitro and in vivo studies. BMC Complement Altern Med 2018; 18(1): 96.
[http://dx.doi.org/10.1186/s12906-018-2151-7] [PMID: 29554903]
[59]
Muluye RA, Bian Y, Alemu PN. Anti-inflammatory and antimicrobial effects of heat-clearing Chinese herbs: a current review. J Tradit Complement Med 2014; 4(2): 93-8.
[http://dx.doi.org/10.4103/2225-4110.126635] [PMID: 24860732]
[60]
Pattnaik S, Subramanyam VR, Bapaji M, Kole CR. Antibacterial and antifungal activity of aromatic constituents of essential oils. Microbios 1997; 89(358): 39-46.
[PMID: 9218354]
[61]
Delaquis PJ, Stanich K, Girard B, Mazza G. Antimicrobial activity of individual and mixed fractions of dill, cilantro, coriander and eucalyptus essential oils. Int J Food Microbiol 2002; 74(1-2): 101-9.
[http://dx.doi.org/10.1016/S0168-1605(01)00734-6] [PMID: 11929164]
[62]
Cosentino S, Tuberoso CI, Pisano B, et al. In-vitro antimicrobial activity and chemical composition of Sardinian Thymus essential oils. Lett Appl Microbiol 1999; 29(2): 130-5.
[http://dx.doi.org/10.1046/j.1472-765X.1999.00605.x] [PMID: 10499301]
[63]
Wu T, Wang Q, Jiang C, et al. Neo-clerodane diterpenoids from Scutellaria barbata with activity against Epstein-Barr virus lytic replication. J Nat Prod 2015; 78(3): 500-9.
[http://dx.doi.org/10.1021/np500988m] [PMID: 25647077]
[64]
Liu HL, Kao TH, Shiau CY, Chen BH. Functional components in Scutellaria barbata D. Don with anti-inflammatory activity on RAW 264.7 cells. Yao Wu Shi Pin Fen Xi 2018; 26(1): 31-40.
[http://dx.doi.org/10.1016/j.jfda.2016.11.022] [PMID: 29389569]
[65]
Liu W, Wang H, Pang X, Yao W, Gao X. Characterization and antioxidant activity of two low-molecular-weight polysaccharides purified from the fruiting bodies of Ganoderma lucidum. Int J Biol Macromol 2010; 46(4): 451-7.
[http://dx.doi.org/10.1016/j.ijbiomac.2010.02.006] [PMID: 20153767]
[66]
Ye CL, Huang Q. Extraction of polysaccharides from herbal Scutellaria barbata D. Don (Ban-Zhi-Lian) and their antioxidant activity. Carbohydr Polym 2012; 89(4): 1131-7.
[http://dx.doi.org/10.1016/j.carbpol.2012.03.084] [PMID: 24750924]
[67]
Li J, Wang Y, Lei JC, et al. Sensitisation of ovarian cancer cells to cisplatin by flavonoids from Scutellaria barbata. Nat Prod Res 2014; 28(10): 683-9.
[http://dx.doi.org/10.1080/14786419.2013.871547] [PMID: 24359131]
[68]
Wu XG, Wang SS, Miao H, Cheng JJ, Zhang SF, Shang YZ. Scutellaria barbata flavonoids alleviate memory deficits and neuronal injuries induced by composited Aβ in rats. Behav Brain Funct 2016; 12(1): 33.
[http://dx.doi.org/10.1186/s12993-016-0118-8] [PMID: 27931218]
[69]
Yang JY, Kim MG, Lee HS. Acaricidal toxicities of 1-hydroxynaphthalene from Scutellaria barbata and its derivatives against house dust and storage mites. Planta Med 2013; 79(11): 946-51.
[http://dx.doi.org/10.1055/s-0032-1328631] [PMID: 23757178]
[70]
Li PW, Hao YX, Cui HJ. Toxicity observation of large dose Scutellaria barbata in prescription. J Tradit Chin Med 1987; (04): 36-7.
[71]
Lv YZ, Kong QZ. Clinical study on banzhilian bushen mixture in the treatment of advanced non-small cell lung cancer. Chin J of Oncol Prev and Treat 2009; 1(03): 232-4.
[72]
Wang Y. Study on Scutellaria barbata. J clin rational drug use 2013; 6(29): 58.
[73]
Pan YZ, Yin DF, Zhang NS, Xing QY. Experimental study on the effect of combined therapy of Xiaoji Decoction and traditional Chinese medicine on cisplatin-resistant ovarian cancer in vitro. Zhonghua Zhongyiyao Xuekan 2008; 1: 77-9.
[74]
Wang HC, Zhao YL. Clinical analysis of Tuyuan Decoction in the treatment of ovarian cancer. Liaoning Zhongyiyao Daxue Xuebao 2008; 8: 110-1.
[75]
Zhang R, Yang Y. 32 Cases of malignant tumor treated by interventional therapy with zengmian quxie prescription. Jilin Med J 2012; 33(10): 2138-9.
[76]
Qiao WH, Zhang YS. 105 Cases of chronic hepatitis B treated by hepatitis B prescription. Shaanxi J Trad Chin Med 2008; 05: 561-2.
[77]
Wang GY. 78 Cases of hepatitis and hepatic fibrosis treated with Ruangan powder. Shaanxi J Trad Chin Med 2011; 32(05): 523-4.
[78]
Cao ZQ. Clinical study of Qilian Shupi granule in reversing precancerous lesions of atrophic gastritis. J Hebei Trad Chin Med Pharmacol 2003; (04): 10-3.
[79]
Luo KY. 87 Cases of chronic gastritis treated by Hedyotis diffusa and Scutellaria barbata. Chinese J Integ Chinese Western Med Spleen Stomach 2000; (2): 116.
[80]
Xu Y, Chen F. 30 Cases of chronic atrophic gastritis of Qi deficiency and blood stasis type treated with Yiwei Decoction. Shaanxi J Trad Chin Med 2010; 31(09): 1130-1.
[81]
Guo BX. 96 Cases of chronic pelvic inflammation treated by combination of traditional chinese medicine and western medicine. Shaanxi J Trad Chin Med 2007; (07): 794-5.
[82]
Pan J. Treatment of 56 Cases of chronic pelvic inflammation with Yiqing Decoction and Manpen No.1. Shaanxi J Trad Chin Med 2007; (11): 1467-8.
[83]
Tan DZ. Clinical study of Yangyin decoction in treating allergic Purpura nephritis with excessive heat and toxin. Heilongjiang Inst Trad Chinese Med 2010.
[84]
Chen CL. Clinical observation on the treatment of chronic renal failure with Yiqi Huoxue Jiangzhuo prescription. Shaanxi J Trad Chin Med 2010; 31(12): 1582-3.
[85]
Zhang QH, Zhang GS. 60 Cases of chronic prostatitis treated with compound Banzhilian decoction. J New Chin Med 1994; (01): 32-4.
[86]
Zhang QH, Zhang GS. Treatment of 55 cases of senile prostatic hypertrophy with Qilong decoction. J New Chin Med 1995; 2: 23-4.
[87]
Zhang ChZh, Zhang YF, Chen JP, Liang XM. Purification and characterization of baicalin-β-D-glucuronidase hydrolyzing baicalin to baicalein from fresh roots of Scutellaria viscidula Bge. Process Biochem 2005; 40(5): 1911-5.
[http://dx.doi.org/10.1016/j.procbio.2004.07.003]
[88]
Xiao HT, Li X. Chemical constituents of Scutellaria barbata. J Shenyang Pharm Univ 2006; (10): 637-40.
[89]
Lin CC, Shieh DE. In vivo hepatoprotective effect of baicalein, baicalin and wogonin from Scutellaria rivularis. Phytother Res 2015; 10(8): 651-4.
[http://dx.doi.org/10.1002/(SICI)1099-1573(199612)10:8<651:AID-PTR651>3.0.CO;2-L]
[90]
Wang ZQ. Briefing on the chemical constituents of Scutellaria barbata. Chin Herb Med 1981; 12(02): 19-7.
[91]
Sonoda M, Nishiyama T, Matsukawa Y, Moriyasu M. Cytotoxic activities of flavonoids from two Scutellaria plants in Chinese medicine. J Ethnopharmacol 2004; 91(1): 65-8.
[http://dx.doi.org/10.1016/j.jep.2003.11.014] [PMID: 15036470]
[92]
Wu LJ. Natural pharmaceutical chemistry. People's Health Pub House 2007.
[93]
Z.Q Wang, F.M Xu, X.Z Yan. Scutebarsatinea a new neo-clerodane type diterpenoid alkaloid from Scutellaria barbata. chinese chemical letters 1996; (04): 333-4.
[94]
Dai SJ, Tao JY, Liu K, Jiang YT, Shen L. neo-Clerodane diterpenoids from Scutellaria barbata with cytotoxic activities. Phytochemistry 2006; 67(13): 1326-30.
[http://dx.doi.org/10.1016/j.phytochem.2006.04.024] [PMID: 16769097]
[95]
Dai SJ, GF W M C. Five new neo-clerodane diterpenoid alkaloids from Scutellaria barbata with cytotoxic activities. Chem Pharm Bull (Tokyo) 2011; 11(5): 451-6.
[96]
Yang SL. Isolation of Anti-tumor active components from Scutellaria barbata. Guangdong Univ Technol 2002.
[97]
YU QY, Zhang DW, Dai SJ. Isolation and identification of chemical constituents from Scutellaria barbata. Mod Chin Med 2011; 13(02): 25-8.
[98]
Wang G, Wang F, Liu JK. Two new phenols from Scutellaria barbata. Molecules 2011; 16(2): 1402-8.
[http://dx.doi.org/10.3390/molecules16021402] [PMID: 21301412]
[99]
Separation of E-1(4'-hydroxyphenyl) -butyl-1-ene-3-one from Scutellaria barbata L. Foreign Med (Vol Trad Chinese Med) 1997; (5): 54.

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