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Current Topics in Medicinal Chemistry

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ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

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Review Article

Progress in the Mechanism and Clinical Application of Cilostazol

Author(s): Huilei Zheng, Hua Yang, Danping Gong, Lanxian Mai, Xiaoling Qiu, Lidai Chen, Xiaozhou Su, Ruoqi Wei and Zhiyu Zeng*

Volume 19, Issue 31, 2019

Page: [2919 - 2936] Pages: 18

DOI: 10.2174/1568026619666191122123855

Price: $65

Abstract

Cilostazol is a unique platelet inhibitor that has been used clinically for more than 20 years. As a phosphodiesterase type III inhibitor, cilostazol is capable of reversible inhibition of platelet aggregation and vasodilation, has antiproliferative effects, and is widely used in the treatment of peripheral arterial disease, cerebrovascular disease, percutaneous coronary intervention, etc. This article briefly reviews the pharmacological mechanisms and clinical application of cilostazol.

Keywords: Cilostazol, Mechanism, Clinical application, Anti-platelet aggregation, Antiplatelet drugs, ADP.

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