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Current Protein & Peptide Science

Editor-in-Chief

ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

Review Article

Characteristics of Asian Mosquito Saliva Allergens for Specific Diagnoses and Effective Therapies

Author(s): Soung-Hoo Jeon*

Volume 21, Issue 2, 2020

Page: [153 - 158] Pages: 6

DOI: 10.2174/1389203720666190729122614

Price: $65

Abstract

An allergic reaction to mosquitoes can result in severe or abnormal local or systemic reactions such as anaphylaxis, angioedema, and general urticarial or wheezing. The aim of this review is to provide information on mosquito saliva allergens that can support the production of highly specific recombinant saliva allergens. In particular, candidate allergens of mosquitoes that are well suited to the ecology of mosquitoes that occur mainly in East Asia will be identified and introduced. By doing so, the diagnosis and treatment of patients with severe sensitivity to mosquito allergy will be improved by predicting the characteristics of East Asian mosquito allergy, presenting the future direction of production of recombinant allergens, and understanding the difference between East and West.

Keywords: Mosquito, allergy, salivary proteins, recombinant allergens, immunoglobulin, Asian.

Graphical Abstract

[1]
Wongkamchai, S.; Khongtak, P.; Leemingsawat, S.; Komalamisra, N.; Junsong, N.; Kulthanan, K.; Wisuthsarewong, W.; Boitano, J.J. Comparative identification of protein profiles and major allergens of saliva, salivary gland and whole body extracts of mosquito species in Thailand. Asian Pac. J. Allergy Immunol., 2010, 28(2-3), 162-169.
[PMID: 21038786]
[2]
Peng, Z.; Simons, F.E. Advances in mosquito allergy. Curr. Opin. Allergy Clin. Immunol., 2007, 7(4), 350-354.
[http://dx.doi.org/10.1097/ACI.0b013e328259c313] [PMID: 17620829]
[3]
Tatsuno, K.; Fujiyama, T.; Matsuoka, H.; Shimauchi, T.; Ito, T.; Tokura, Y. Clinical categories of exaggerated skin reactions to mosquito bites and their pathophysiology. J. Dermatol. Sci., 2016, 82(3), 145-152.
[http://dx.doi.org/10.1016/j.jdermsci.2016.04.010] [PMID: 27177994]
[4]
Asada, H. Hypersensitivity to mosquito bites: a unique pathogenic mechanism linking Epstein-Barr virus infection, allergy and oncogenesis. J. Dermatol. Sci., 2007, 45(3), 153-160.
[http://dx.doi.org/10.1016/j.jdermsci.2006.11.002] [PMID: 17169531]
[5]
Crisp, H.C.; Johnson, K.S. Mosquito allergy. Ann. Allergy Asthma Immunol., 2013, 110(2), 65-69.
[http://dx.doi.org/10.1016/j.anai.2012.07.023] [PMID: 23352522]
[6]
Singh, S.; Mann, B.K. Insect bite reactions. Indian J. Dermatol. Venereol. Leprol., 2013, 79(2), 151-164.
[http://dx.doi.org/10.4103/0378-6323.107629] [PMID: 23442453]
[7]
Peng, Z.; Beckett, A.N.; Engler, R.J.; Hoffman, D.R.; Ott, N.L.; Simons, F.E. Immune responses to mosquito saliva in 14 individuals with acute systemic allergic reactions to mosquito bites. J. Allergy Clin. Immunol., 2004, 114(5), 1189-1194.
[http://dx.doi.org/10.1016/j.jaci.2004.08.014] [PMID: 15536430]
[8]
Kulthanan, K.; Wongkamchai, S.; Triwongwaranat, D. Mosquito allergy: clinical features and natural course. J. Dermatol., 2010, 37(12), 1025-1031.
[http://dx.doi.org/10.1111/j.1346-8138.2010.00958.x] [PMID: 21083704]
[9]
Ree, H.I.; Shin, H.J.; Lee, K.T. Studies on bionomics of Aedes togoi, the vector of Brugian filariasis in Korea. Yonsei Reports on Tropical Medicine, 1987, 18(0), 17-23.
[10]
Vega-Rúa, A.; Schmitt, C.; Bonne, I.; Krijnse Locker, J.; Failloux, A.B. Chikungunya virus replication in salivary glands of the mosquito Aedes albopictus. Viruses, 2015, 7(11), 5902-5907.
[http://dx.doi.org/10.3390/v7112917] [PMID: 26593936]
[11]
Fehrenbach, M.J.; Popowics, T. Illustrated Dental Embryology, Histology, and Anatomy, 4th ed; Elsevier Health Sciences: New York, 2015.
[12]
Choi, K.M.; Lee, K.Y.; Jeon, S.H. Identification of salivary proteins in Aedes togoi (Theobald) that bind to mouse immunoglobulin E. Entomol. Res., 2018, 48(0), 222-226.
[http://dx.doi.org/10.1111/1748-5967.12302]
[13]
Shaalan, E.A.; Canyon, D.; Younes, M.W.; Abdel-Wahab, H.; Mansour, A.H. A review of botanical phytochemicals with mosquitocidal potential. Environ. Int., 2005, 31(8), 1149-1166.
[http://dx.doi.org/10.1016/j.envint.2005.03.003] [PMID: 15964629]
[14]
Mackay, I.; Rose, N.R.; Ledford, D.K.; Lockey, R.F. Encyclopedia of Medical Immunology.Allergic diseases; Springer: New York, 2014.
[15]
Peng, Z.; Simons, F.E. A prospective study of naturally acquired sensitization and subsequent desensitization to mosquito bites and concurrent antibody responses. J. Allergy Clin. Immunol., 1998, 101(2 Pt 1), 284-286.
[http://dx.doi.org/10.1016/S0091-6749(98)70395-1] [PMID: 9500765]
[16]
Simons, F.E.; Peng, Z. Skeeter syndrome. J. Allergy Clin. Immunol., 1999, 104(3 Pt 1), 705-707.
[http://dx.doi.org/10.1016/S0091-6749(99)70348-9] [PMID: 10482852]
[17]
Engler, R.J. Mosquito bite pathogenesis in necrotic skin reactors. Curr. Opin. Allergy Clin. Immunol., 2001, 1(4), 349-352.
[http://dx.doi.org/10.1097/00130832-200108000-00011] [PMID: 11964711]
[18]
Walker, G.B.; Harrison, P.V. Seasonal bullous eruption due to mosquitoes. Clin. Exp. Dermatol., 1985, 10(2), 127-132.
[http://dx.doi.org/10.1111/j.1365-2230.1985.tb00540.x] [PMID: 3884192]
[19]
Mellanby, K. Man’s reaction to mosquito bites. Nature, 1946, 158(4016), 554.
[http://dx.doi.org/10.1038/158554c0] [PMID: 21001941]
[20]
Heilesen, B. Studies on mosquito bites. Acta Allergol., 1949, 2(3), 245-267.
[http://dx.doi.org/10.1111/j.1398-9995.1949.tb03310.x] [PMID: 15395154]
[21]
McKiel, J.A.; West, A.S. Effects of repeated exposures of hypersensitive humans and laboratory rabbits to mosquito antigens. Can. J. Zool., 1961, 39, 7.
[http://dx.doi.org/10.1139/z61-064]
[22]
Ostrom, N.K.; Swanson, M.C.; Agarwal, M.K.; Yunginger, J.W. Occupational allergy to honeybee-body dust in a honey-processing plant. J. Allergy Clin. Immunol., 1986, 77(5), 736-740.
[http://dx.doi.org/10.1016/0091-6749(86)90420-3] [PMID: 3700899]
[23]
Swanson, M.C.; Agarwal, M.K.; Reed, C.E. An immunochemical approach to indoor aeroallergen quantitation with a new volumetric air sampler: studies with mite, roach, cat, mouse, and guinea pig antigens. J. Allergy Clin. Immunol., 1985, 76(5), 724-729.
[http://dx.doi.org/10.1016/0091-6749(85)90678-5] [PMID: 4056257]
[24]
Reunala, T.; Brummer-Korvenkontio, H.; Räsänen, L.; François, G.; Palosuo, T. Passive transfer of cutaneous mosquito-bite hypersensitivity by IgE anti-saliva antibodies. J. Allergy Clin. Immunol., 1994, 94(5), 902-906.
[http://dx.doi.org/10.1016/0091-6749(94)90158-9] [PMID: 7525679]
[25]
Brummer-Korvenkontio, H.; Lappalainen, P.; Reunala, T.; Palosuo, T. Detection of mosquito saliva-specific IgE and IgG4 antibodies by immunoblotting. J. Allergy Clin. Immunol., 1994, 93(3), 551-555.
[http://dx.doi.org/10.1016/S0091-6749(94)70066-4] [PMID: 8151057]
[26]
Chen, Y.L.; Simons, F.E.; Peng, Z. A mouse model of mosquito allergy for study of antigen-specific IgE and IgG subclass responses, lymphocyte proliferation, and IL-4 and IFN-gamma production. Int. Arch. Allergy Immunol., 1998, 116(4), 269-277.
[http://dx.doi.org/10.1159/000023955] [PMID: 9693276]
[27]
Cantillo, J.F.; Fernández-Caldas, E.; Puerta, L. Immunological aspects of the immune response induced by mosquito allergens. Int. Arch. Allergy Immunol., 2014, 165(4), 271-282.
[http://dx.doi.org/10.1159/000371349] [PMID: 25661054]
[28]
Demeure, C.E.; Brahimi, K.; Hacini, F.; Marchand, F.; Péronet, R.; Huerre, M.; St-Mezard, P.; Nicolas, J.F.; Brey, P.; Delespesse, G.; Mécheri, S. Anopheles mosquito bites activate cutaneous mast cells leading to a local inflammatory response and lymph node hyperplasia. J. Immunol., 2005, 174(7), 3932-3940.
[http://dx.doi.org/10.4049/jimmunol.174.7.3932] [PMID: 15778349]
[29]
Abdel-Naser, M.B.; Lotfy, R.A.; Al-Sherbiny, M.M.; Sayed Ali, N.M. Patients with papular urticaria have IgG antibodies to bedbug (Cimex lectularius) antigens. Parasitol. Res., 2006, 98(6), 550-556.
[http://dx.doi.org/10.1007/s00436-005-0076-9] [PMID: 16425065]
[30]
Heng, M.C.; Kloss, S.G.; Haberfelde, G.C. Pathogenesis of papular urticaria. J. Am. Acad. Dermatol., 1984, 10(6), 1030-1034.
[http://dx.doi.org/10.1016/S0190-9622(84)80330-8] [PMID: 6736320]
[31]
Alexander, J.O. Papular urticaria and immune complexes. J. Am. Acad. Dermatol., 1985, 12(2 Pt 1), 374-375.
[http://dx.doi.org/10.1016/S0190-9622(85)80065-7] [PMID: 3973134]
[32]
Peng, Z.; Li, H.; Simons, F.E. Immunoblot analysis of salivary allergens in 10 mosquito species with worldwide distribution and the human IgE responses to these allergens. J. Allergy Clin. Immunol., 1998, 101(4 Pt 1), 498-505.
[http://dx.doi.org/10.1016/S0091-6749(98)70357-4] [PMID: 9564803]
[33]
Peng, Z.; Simons, F.E. Mosquito allergy: immune mechanisms and recombinant salivary allergens. Int. Arch. Allergy Immunol., 2004, 133(2), 198-209.
[http://dx.doi.org/10.1159/000076787] [PMID: 14963366]
[34]
Jeon, S.H.; Park, J.W.; Lee, B.H. Characterization of human IgE and mouse IgG1 responses to allergens in three mosquito species by immunoblotting and ELISA. Int. Arch. Allergy Immunol., 2001, 126(3), 206-212.
[http://dx.doi.org/10.1159/000049515] [PMID: 11752877]
[35]
Sun, D.; McNicol, A.; James, A.A.; Peng, Z. Expression of functional recombinant mosquito salivary apyrase: a potential therapeutic platelet aggregation inhibitor. Platelets, 2006, 17(3), 178-184.
[http://dx.doi.org/10.1080/09537100500460234] [PMID: 16702045]
[36]
Ribeiro, J.M.; Sarkis, J.J.; Rossignol, P.A.; Spielman, A. Salivary apyrase of Aedes aegypti: characterization and secretory fate. Comp. Biochem. Physiol. B, 1984, 79(1), 81-86.
[http://dx.doi.org/10.1016/0305-0491(84)90081-6] [PMID: 6094095]
[37]
James, A.A.; Blackmer, K.; Marinotti, O.; Ghosn, C.R.; Racioppi, J.V. Isolation and characterization of the gene expressing the major salivary gland protein of the female mosquito, Aedes aegypti. Mol. Biochem. Parasitol., 1991, 44(2), 245-253.
[http://dx.doi.org/10.1016/0166-6851(91)90010-4] [PMID: 2052024]
[38]
Nascimento, E.P.; dos Santos Malafronte, R.; Marinotti, O. Salivary gland proteins of the mosquito Culex quinquefasciatus. Arch. Insect Biochem. Physiol., 2000, 43(1), 9-15.
[http://dx.doi.org/10.1002/(SICI)1520-6327(200001)43:1<9:AID-ARCH2>3.0.CO;2-2] [PMID: 10613958]
[39]
Peng, Z.; Simons, F.E. Comparison of proteins, IgE, and IgG binding antigens, and skin reactivity in commercial and laboratory-made mosquito extracts. Ann. Allergy Asthma Immunol., 1996, 77(5), 371-376.
[http://dx.doi.org/10.1016/S1081-1206(10)63335-2] [PMID: 8933775]
[40]
Peng, Z.; Simons, F.E.R. Cross-reactivity of skin and serum specific IgE responses and allergen analysis for three mosquito species with worldwide distribution. J. Allergy Clin. Immunol., 1997, 100(2), 192-198.
[http://dx.doi.org/10.1016/S0091-6749(97)70224-0] [PMID: 9275140]

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