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Current Topics in Medicinal Chemistry

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ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

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Review Article

STAT3: A Potential Drug Target for Tumor and Inflammation

Author(s): Yang Sheng Hu, Xu Han and Xin Hua Liu*

Volume 19, Issue 15, 2019

Page: [1305 - 1317] Pages: 13

DOI: 10.2174/1568026619666190620145052

Price: $65

Abstract

STAT (Signal Transducers and Activators of Transcription) is a cellular signal transcription factor involved in the regulation of many cellular activities, such as cell differentiation, proliferation, angiogenesis in normal cells. During the study of the STAT family, STAT3 was found to be involved in many diseases, such as high expression and sustained activation of STAT3 in tumor cells, promoting tumor growth and proliferation. In the study of inflammation, it was found that it plays an important role in the anti-inflammatory and repairing of damage tissues. Because of the important role of STAT3, a large number of studies have been obtained. At the same time, after more than 20 years of development, STAT3 has also been used as a target for drug therapy. And the discovery of small molecule inhibitors also promoted the study of STAT3. Since STAT3 has been extensively studied in inflammation and tumor regulation, this review presents the current state of research on STAT3.

Keywords: STAT 3, Anti-tumor, Inflammation, Inhibitor, Function, Target.

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