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Current Topics in Medicinal Chemistry

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ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

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Review Article

Therapeutic Potential of Endophytic Compounds: A Special Reference to Drug Transporter Inhibitors

Author(s): Khusbu Singh, Gaurav Raj Dwivedi*, A. Swaroop Sanket and Sanghamitra Pati

Volume 19, Issue 10, 2019

Page: [754 - 783] Pages: 30

DOI: 10.2174/1568026619666190412095105

Price: $65

Abstract

From the discovery to the golden age of antibiotics (miracle), millions of lives have been saved. The era of negligence towards chemotherapeutic agents gave birth to drug resistance. Among all the regulators of drug resistance, drug transporters are considered to be the key regulators for multidrug resistance. These transporters are prevalent from prokaryotes to eukaryotes. Endophytes are one of the unexplored wealths of nature. Endophytes are a model mutualistic partner of plants. They are the reservoir of novel therapeutics. The present review deals with endophytes as novel drug resistance reversal agents by inhibiting the drug transporters across the genera. This review also focuses on drug transporters, and mutualistic chemical diversity, exploring drug transporter modulating potential of endophytes.

Keywords: Endophytes, Antibiotics, Multidrug resistance, Drug transporters, Therapeutics, Modulator.

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