Synthesis and Anti Lung Cancer Activity of 3-Arylspiro[oxirane-2,3'- thiochroman]-4'-one Derivatives

Title:Synthesis and Anti Lung Cancer Activity of 3-Arylspiro[oxirane-2,3'- thiochroman]-4'-one Derivatives

Volume: 16 Issue: 6

Author(s): Dhananjay Pandya and Yogesh Naliapara*

Affiliation:

• Department of Chemistry, Saurashtra University, Rajkot, Gujarat,India

Keywords: 3-Arylspiro[oxirane-2, 3' thiochroman]-4'-ones, α, β-epoxyketones, anticancer agents, epoxides, Darzen condensation, human lung cancer cell line A-549.

Abstract: A series of 3-arylspiro[oxirane-2,3'-thiochroman]-4'-one derivatives were synthesized and characterized by spectroscopy like 1H NMR, 13C NMR, mass spectrometry and elemental analysis. They were evaluated for their anti-lung cancer activity on human lung cancer cell line A-549 in DMSO. Compounds under study were found to be potent anti-lung cancer agents with GI50 values less than 10 with respect to positive control adriamycin.

Cite this article as:

Pandya Dhananjay and Naliapara Yogesh *, Synthesis and Anti Lung Cancer Activity of 3-Arylspiro[oxirane-2,3'- thiochroman]-4'-one Derivatives, Letters in Organic Chemistry 2019; 16 (6) . https://dx.doi.org/10.2174/1570178616666181130163914