Bradykinin Receptors in Ischemic Injury

Title:Bradykinin Receptors in Ischemic Injury

Volume: 15 Issue: 4

Author(s): Min Tang*, Fangping He, Li Ma, Ping Liu, Jianwen Wang and Xiongchao Zhu

Affiliation:

• Department of Neurology, The First Affiliated Hospital, School of Medicine, Zhejiang University, #79 Qingchun Road, Hangzhou, Zhejiang Province 310003,China

Keywords: Kallikrein-Kinin System (KKS), Bradykinin (BK), B1 Receptor (B1R), B2 Receptor (B2R), myocardial ischemia, ischemia/reperfusion, hypoxia/reperfusion, angiogenesis, apoptosis.

Abstract: Bradykinin (BK) is a major kinin substance in the Kallikrein-Kinin System (KKS) that acts in conjunction with target cell bradykinin receptors and is involved in a variety of systems and organs. Functional regulation and pathophysiological processes such as cardiovascular, renal, central nervous system regulation, glucose metabolism, cell proliferation, smooth muscle contraction, inflammation, pain, shock, and tissue damage processes, etc. The role and mechanism of receptors in the mediation of ischemic injury in tissues was reviewed.

Cite this article as:

Tang Min *, He Fangping , Ma Li , Liu Ping , Wang Jianwen and Zhu Xiongchao , Bradykinin Receptors in Ischemic Injury, Current Neurovascular Research 2018; 15 (4) . https://dx.doi.org/10.2174/1567202616666181123151629