Natural-based Antibiofilm and Antimicrobial Peptides from Microorganisms

Title:Natural-based Antibiofilm and Antimicrobial Peptides from Microorganisms

Volume: 18 Issue: 24

Author(s): Aysenur Yazici, Serkan Ortucu*, Mesut Taskin and Lisa Marinelli

Affiliation:

• Department of Molecular Biology and Genetics, Science Faculty, Erzurum Technical University, Erzurum,Turkey

Keywords: Antimicrobial peptide, Antibiofilm peptide, Production, Biofilm, Screening, Organisms.

Abstract: As the resistance to antimicrobial molecules increases among bacteria, the need for new antimicrobial molecules increases. Antimicrobial peptides (AMP), which may be a new generation of antibiotic candidates, are important in this respect. AMPs are small, cationic and amphipathic peptide sequences. In eukaryotes, they are synthesized as a part of the immune system. Substantially, AMPs are discovered in all kingdoms of life such as bacteria, fungi and protozoa. Approximately 3,000 AMPs have been reported in the literature. However, most of these AMPs have been synthesized through chemical synthesis. Nature has a huge source of microorganisms, and in the literature, there is a tendency to increase every year the number of bacteria and fungus-derived AMPs thanks to their biotechnological importance. The exploration of AMP and antibiofilm peptide (ABP) producer microorganisms brings with it a lot of challenges experimentally. In this review study, we want to highlight the importance and challenge of these natural peptides derived from microorganisms. We will also propose a new explanation for ABPs.

Cite this article as:

Yazici Aysenur , Ortucu Serkan *, Taskin Mesut and Marinelli Lisa , Natural-based Antibiofilm and Antimicrobial Peptides from Microorganisms, Current Topics in Medicinal Chemistry 2018; 18 (24) . https://dx.doi.org/10.2174/1568026618666181112143351