Metabolomics-based Approach to Pharmacotherapy Personalization: Advantages and Limitations

Title:Metabolomics-based Approach to Pharmacotherapy Personalization: Advantages and Limitations

Volume: 16 Issue: 3

Author(s): Dmitry L. Maslov*, Elena E. Balashova, Oxana P. Trifonova and Petr G. Lokhov

Affiliation:

• Institute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121, Moscow,Russian Federation

Keywords: Metabolomics, pharmacometabolomics, pharmacogenomics, personalized medicine, mass spectrometry, metabolomics-based approach.

Abstract: Background: A patient-focused approach to treatment, where individual characteristics provide the selection of optimal medication strategy for a particular patient, is the trend of current clinical therapy. An application of advanced “omics” technologies, which enable to detect the inter-individual variability in genomic, transcriptomic, proteomic, and metabolomic levels is a perspective way to achieve such personalization.

Objective: In this review, the advantages of metabolomics-based approach as one of the most promising and perspective for individualization of pharmacotherapy are demonstrated. This approach provides a prediction of the inter-individual variability in drug response and allows monitoring effectiveness of drug treatment, correcting it in account of individual parameters of patients.

Method: Comparative analysis of metabolomics-based approach and the current methods of drug treatment personalization are carried out.

Results: Advantages and limitations of the metabolomics-based approach were identified and discussed.

Conclusion: The perspective ways for solution of limitations of the metabolomics-based approach are considered.

Cite this article as:

Maslov L. Dmitry*, Balashova E. Elena, Trifonova P. Oxana and Lokhov G. Petr, Metabolomics-based Approach to Pharmacotherapy Personalization: Advantages and Limitations, Current Pharmacogenomics and Personalized Medicine 2018; 16 (3) . https://dx.doi.org/10.2174/1875692116666181008144905