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The Natural Products Journal

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ISSN (Print): 2210-3155
ISSN (Online): 2210-3163

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Research Article

In vitro Characterization of Microspheres Containing Chemically Cross- Linked Gummy Exudates of Cochlospermum religiosum

Author(s): Vipin Kumar Sharma*, Bhaskar Mazumder, Vinod Nautiyal, Prince Prashant Sharma and Yusra Ahmed

Volume 9, Issue 3, 2019

Page: [217 - 228] Pages: 12

DOI: 10.2174/2210315508666181004144520

Price: $65

Abstract

Background: The polymeric hydrocolloids of natural origin such as gums and mucilages have their own significance in food and pharmaceutical industries due to safety, cost, biodegradability, biocompatibility, etc.

Objective: This study includes the assessment of feasibility of gummy exudates of Cochlospermum religiosum for development of microspheres through emulsification technique.

Methods: The effects of exudates concentration, glutaraldehyde amount and process temperature were analyzed on particle-size and swelling dynamics of developed microspheres. The formulations were also characterized by thermal decomposition and powder X-ray diffraction technique to assess the effect of crosslinking.

Results: The photomicrographs of preparations revealed the formation of microspheres with smooth, spherical and free-flowing nature. The swelling dynamics followed Fick’s diffusion mechanism for swelling media. Fourier transform infrared spectroscopy showed the formation of ether-linkage after crosslinking of exudates by glutaraldehyde. The thermogravimetric curves disclosed the formation of strong bonds during crosslinking.

Conclusion: The ease of gummy exudates of Cochlospermum religiosum for microspheres formation ascribed the potential of these formulations to incorporate therapeutic agent(s) to be applied as novel drug-carriers.

Keywords: Swelling dynamics, thermogravimetry, powder X-ray diffractometry, crosslinking, gummy exudates, thermal decomposition.

Graphical Abstract

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