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Current Rheumatology Reviews

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ISSN (Print): 1573-3971
ISSN (Online): 1875-6360

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Case Report

Neurological Involvement as the Initial Manifestation in Primary Sjögren's Syndrome - A Case Report

Author(s): Iván Posso-Osorio, Juan Naranjo-Escobar, Diana Marcela Loaiza, Marcela Polo, Alex Echeverri and Gabriel J. Tobón*

Volume 15, Issue 3, 2019

Page: [254 - 258] Pages: 5

DOI: 10.2174/1573397114666180731101142

Price: $65

Abstract

Background: Sjögren's syndrome is an autoimmune disease characterised by exocrinopathy mainly involving the salivary and lacrimal glands. In addition, it is a multisystemic condition (i.e., affecting multiple organs and systems). Neurological involvement has been reported in ~20% of cases, with peripheral manifestations being the most frequent.

Methods: We analysed four cases in which neurological manifestations were the first symptoms of Sjögren's syndrome.

Results: In all four cases, neurological symptoms preceded sicca symptoms. In addition, immunosuppressive treatment with steroids and, in some cases, cyclophosphamide showed improvement.

Conclusion: Neurological involvement in Sjögren's syndrome is common and often occurs as the first clinical manifestation. Since evidence is limited, more studies are required in order to determine appropriate diagnostic methods and treatments for each manifestation of Sjögren's syndrome.

Keywords: Neurological involvement, primary Sjögren's syndrome, autoimmune disease, sicca symptoms, exocrinopathy, peripheral neuropathy.

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