Prognostic Value of White Blood Cell in Acute Ischemic Stroke Patients

Title:Prognostic Value of White Blood Cell in Acute Ischemic Stroke Patients

Volume: 15 Issue: 2

Author(s): Xiaowei Zheng, Nimei Zeng, Aili Wang, Zhengbao Zhu, Chongke Zhong, Tan Xu, Tian Xu, Yanbo Peng, Hao Peng, Qunwei Li, Zhong Ju, Deqin Geng, Yonghong Zhang*Jiang He

Affiliation:

• Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou,China

Keywords: White blood cell, acute ischemic stroke, prognostic value, CATIS, atherosclerosis, C-reactive protein.

Abstract: Background and Aims: It is unclear whether white blood cell on admission has a prognosis value on ischemic stroke and whether its function is affected by other inflammation factors. We hypothesized that elevated white blood cell is associated with stroke severity and 3-month mortality after acute ischemic stroke.

Methods: A total of 3891 acute ischemic stroke subjects from the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS) were included in this analysis. Participants were divided into four groups according to quartiles of white blood cell on admission (cutoff points for the quintiles: 5.60×10⁹/L,6.83×10⁹/L,8.50×10⁹/L). The primary outcome was a combination of death and major disability (modified Rankin Scale score ≥3) at 3 months. Secondary outcomes were major disability, death, and vascular events, respectively.

Results: After adjustment for major conventional risk factors, elevated white blood cell on admission was associated with poor primary and secondary outcomes after acute ischemic stroke. Compared with the lowest quartile, the ORs (95% CIs) for the highest quartile were 1.79 (1.37-2.91) and 1.62 (1.21-3.55) for primary outcome in model 1 and model 2. In addition, there was a linear association between white blood cell and primary outcome at 3-months (P for linear trend = 0.001).

Conclusion: This analysis indicated that elevated white blood cell on admission is associated with 3-months poor prognosis in ischemic stroke patients independently of other inflammation factors. The results emphasize the need for further research on the application of anti-inflammatory therapy.

Cite this article as:

Zheng Xiaowei, Zeng Nimei , Wang Aili, Zhu Zhengbao , Zhong Chongke , Xu Tan, Xu Tian , Peng Yanbo , Peng Hao , Li Qunwei , Ju Zhong, Geng Deqin , Zhang Yonghong *, He Jiang , Prognostic Value of White Blood Cell in Acute Ischemic Stroke Patients, Current Neurovascular Research 2018; 15 (2) . https://dx.doi.org/10.2174/1567202615666180626154857