Effects of Immunosenescence on the Lower Expression of Surface Molecules in Neutrophils and Lymphocytes

Title:Effects of Immunosenescence on the Lower Expression of Surface Molecules in Neutrophils and Lymphocytes

Volume: 11 Issue: 2

Author(s): Alessandra B. Lopes*, Larissa B. Lopes, Roseli N. da Silveira Antunes, Josianne T. Fukasawa, Débora de A. Cavaretto and Zamir Calamita

Affiliation:

• Postgraduate Program in Health and Aging, Marilia School of Medicine - FAMEMA, Rua Monte Carmelo, 800, Fragata, CEP: 17519-030, Marilia - SP,Brazil

Keywords: Immunosenescence, aging, neutrophils, lymphocytes, CD11b, CD40.

Abstract: Background: Immunosenescence is a remodeling of the immune system, caused by aging, with changes in the function of neutrophils, lymphocytes, and Treg cells.

Objective: This study aimed to evaluate the expression of molecules CD11b, CD16 and CD64 (neutrophils), CD154 (T lymphocytes), CD40 (B lymphocytes), and to quantitatively analyze the Treg cell subpopulation.

Methods: 49 elderlies (≥60 years) and 49 adults (≤35 years) were studied. Flow cytometry was used to analyze the expression of surface molecules and the subpopulation of Treg cells, and the results between the groups were compared statistically by the t-test.

Results: There was a decreased significance in the expression of CD11b and CD40 in the elderly.

Conclusion: Decreased CD11b expression can result in susceptibility to infectious diseases, and impairment of phagocytic capacity. Decreased CD40 expression can result in a decline in B lymphocyte activation. The other molecule studied presented alterations not significant, but compatible with the immunological changes in aging.

Cite this article as:

Lopes B. Alessandra *, Lopes B. Larissa , da Silveira Antunes N. Roseli , Fukasawa T. Josianne , de A. Cavaretto Débora and Calamita Zamir , Effects of Immunosenescence on the Lower Expression of Surface Molecules in Neutrophils and Lymphocytes, Current Aging Science 2018; 11 (2) . https://dx.doi.org/10.2174/1874609811666180605092234