Current Applications of the Sonogashira Reaction in the Synthesis of Heterocyclic Compounds: An Update

Title:Current Applications of the Sonogashira Reaction in the Synthesis of Heterocyclic Compounds: An Update

Volume: 22 Issue: 14

Author(s): Majid M. Heravi*, Manizheh Ghanbarian, Nastaran Ghalavand and Niousha Nazari

Affiliation:

• Department of Chemistry, Alzahra University, Vanak, Tehran,Iran

Keywords: Sonogashira, palladium, Pd-catalyzed, Cu-catalyzed, Cu-free, 2-Formyl/acetyl-N-substituted pyrrolo[2, 3-b]quinoxaline, H-Pyrazolo[5, 1-a]isoquinolines, name reaction.

Abstract: The Sonogashira cross-coupling reaction involves the coupling of terminal alkynes with aryl or vinyl halides in the presence of a Pd and a Cu(I) co-catalyst. We tried to reveal the importance of the applications of the Sonogashira reaction in the synthesis of heterocyclic compounds. The reactions occur under relatively mild conditions and tolerate a wide variety of functional groups.

Cite this article as:

Heravi M. Majid *, Ghanbarian Manizheh , Ghalavand Nastaran and Nazari Niousha , Current Applications of the Sonogashira Reaction in the Synthesis of Heterocyclic Compounds: An Update, Current Organic Chemistry 2018; 22 (14) . https://dx.doi.org/10.2174/1385272822666180322122232