Abstract
Background: One of the most important causes of death in the modern lifestyle is acute ischemic stroke, which is related to thrombosis in the blood vessels. Staphylokinase (SAK), a fibrinolytic agent, which is produced mainly by Staphylococcus aureus, is an indirect activator of plasminogen and belongs to the third generation of fibrinolytic enzymes.
Methods: Considering the very low level of production and immunogenicity concerns of natural SAK produced by Staphylococcus aureus, attempts have been made to produce recombinant SAKs with high production levels, more fibrinolytic activities and low immunogenicity.
Results and Conclusion: In this review, we summarized a number of expression systems based on recombinant DNA technology and protein-engineering approaches, which have been developed for the production of engineered recombinant SAK molecules with higher fibrinolytic activities and lower antigenicity.
Keywords: Staphylokinase, fibrinolytics, recombinant, thrombolysis, immunogenicity, plasminogen.
Graphical Abstract
Current Pharmaceutical Biotechnology
Title:Staphylokinase Enzyme: An Overview of Structure, Function and Engineered Forms
Volume: 18 Issue: 13
Author(s): Bahareh Vakili, Navid Nezafat, Manica Negahdaripour, Maryam Yari, Bijan Zare and Younes Ghasemi*
Affiliation:
- Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz,Iran
Keywords: Staphylokinase, fibrinolytics, recombinant, thrombolysis, immunogenicity, plasminogen.
Abstract: Background: One of the most important causes of death in the modern lifestyle is acute ischemic stroke, which is related to thrombosis in the blood vessels. Staphylokinase (SAK), a fibrinolytic agent, which is produced mainly by Staphylococcus aureus, is an indirect activator of plasminogen and belongs to the third generation of fibrinolytic enzymes.
Methods: Considering the very low level of production and immunogenicity concerns of natural SAK produced by Staphylococcus aureus, attempts have been made to produce recombinant SAKs with high production levels, more fibrinolytic activities and low immunogenicity.
Results and Conclusion: In this review, we summarized a number of expression systems based on recombinant DNA technology and protein-engineering approaches, which have been developed for the production of engineered recombinant SAK molecules with higher fibrinolytic activities and lower antigenicity.
Export Options
About this article
Cite this article as:
Vakili Bahareh , Nezafat Navid, Negahdaripour Manica , Yari Maryam, Zare Bijan and Ghasemi Younes *, Staphylokinase Enzyme: An Overview of Structure, Function and Engineered Forms, Current Pharmaceutical Biotechnology 2017; 18 (13) . https://dx.doi.org/10.2174/1389201019666180209121323
DOI https://dx.doi.org/10.2174/1389201019666180209121323 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |

- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Hypertension in Obesity: Novel Insights
Current Hypertension Reviews Editorial: Current Strategies in Targeting Brain Disorders
CNS & Neurological Disorders - Drug Targets Cardiovascular Effects of Phosphodiesterase 5 Inhibitors
Current Pharmaceutical Design Inflammation and Age-Related Iron Accumulation in F344 Rats
Current Aging Science Gene and Gene-Environment Risk Factors in Sudden Undexpected Death in Infants
Current Pediatric Reviews Pathophysiology of IgG4-Related Disease
Current Immunology Reviews (Discontinued) Research Progresses of Targeted Therapy and Immunotherapy for Hepatocellular Carcinoma
Current Medicinal Chemistry Meet Our Section Editor
Current Vascular Pharmacology Chemical and Physical Properties and Potential Mechanisms: Melatonin as a Broad Spectrum Antioxidant and Free Radical Scavenger
Current Topics in Medicinal Chemistry Mesenchymal Stem Cells for Treatment of CNS Injury
Current Neuropharmacology Oxidative Stress, HDL and Atherosclerosis
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Arterial Stiffness, Cognitive Dysfunction and Adherence to Antihypertensive Agents. Is there a Link to Hypertensive Patients?
Current Vascular Pharmacology Castration Resistant Prostate Cancer (CRPC): State of the Art, Perspectives and New Challenges
Anti-Cancer Agents in Medicinal Chemistry Preoperative and Follow up Multi-Detector Row CT Angiography (MDCTA) in the Evaluation of Interrupted Aortic Arch (IAA)
Current Medical Imaging CDK5 and MAPT Gene Expression in Alzheimer's Disease Brain Samples
Current Alzheimer Research Editorial [Hot Topic: Functions and Metabolism of Brain Nucleosides and their Metabolites (Guest Editors: Zsolt Kovacs & Arpad Dobolyi)]
Current Topics in Medicinal Chemistry The Role of Transcranial Magnetic Stimulation in Treatment-Resistant Depression: A Review
Current Pharmaceutical Design Correlation of Salusin Beta with hs-CRP and ADMA in Hypertensive Children and Adolescents
Current Pharmaceutical Design Effect of a Dihydropyridine-Type Calcium Channel Blocker on Vascular Remodelling after Experimental Balloon Angioplasty
Cardiovascular & Hematological Agents in Medicinal Chemistry Nuclear Receptors as Potential Targets for Modulating Reverse Cholesterol Transport
Current Topics in Medicinal Chemistry