Oxidation of Potassium Channels in Neurodegenerative Diseases: A Mini- Review

Title:Oxidation of Potassium Channels in Neurodegenerative Diseases: A Mini- Review

Volume: 17 Issue: 4

Author(s): Junsheng Yang*Xueni Yan

Affiliation:

• Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014,China

Keywords: Aging, neurodegenerative diseases, oxidation, potassium channel, reactive oxygen species (ROS), lipids and proteins.

Abstract: Background & Objective: Increased level of reactive oxygen species is a hallmark of common neurodegenerative diseases such as Alzheimer’s Disease and Parkinson’s Disease. ROS can oxidize macromolecules including DNA, lipids and proteins and cause oxidative damage to the cell. Emerging evidence indicate that potassium channels in the central nervous system are no exceptions to these oxidative modifications.

Conclusion: In this mini-review, we summarized recent reports on the oxidation of potassium channels in the CNS and the consequently resulted changes in cell functions and viability, with focus on its implications in neurodegenerative diseases.

Cite this article as:

Yang Junsheng *, Yan Xueni , Oxidation of Potassium Channels in Neurodegenerative Diseases: A Mini- Review, CNS & Neurological Disorders - Drug Targets 2018; 17 (4) . https://dx.doi.org/10.2174/1871527317666180202110056