Coumarin Derivatives as Anticancer Agents for Lung Cancer Therapy: A Review

Title:Coumarin Derivatives as Anticancer Agents for Lung Cancer Therapy: A Review

Volume: 18 Issue: 7

Author(s): Manvendra Kumar, Ramit Singla, Jyoti Dandriyal and Vikas Jaitak*

Affiliation:

• Centre for Pharmaceutical Sciences and Natural Products, School of Basic and Applied Sciences, Central University of Punjab, Bathinda, 151 001,India

Keywords: Lung cancer, MDR, coumarin, NSCLC, SCLC, multidrug resistance.

Abstract: Background: The prevalence of lung cancer is 14% among the newly diagnosed cancer cases worldwide. Currently, the number of drugs that are in clinical practice is having a high prevalence of side effect and multidrug resistance. Researchers have made an attempt to expand a suitable anticancer drug that has no MDR and side effect.

Objective: Extensive exploration of Coumarin derivatives as a potent inhibitor of variety of proteins including EGFR, tyrosine kinase, ERK1/2, PI3K, HSP 90, Bax, STAT proteins, NF-κB and telomerase which have been associated with lung cancer.

Method: The recent literature was surveyed utilizing the online resources and databases including scifinder, pubchem, EMBL, scopus and google scholar.

Results: Upon analyzing the structure-activity relationship, it was found that N-aryl carboxamide, phenyl substitution at the C-3 position and 1,2,3- triazolyl, trihydroxystilbene, amino substitution at the C-4 position of the coumarin nucleus were the most effective in targeting lung cancer.

Conclusion: This review is a collaborative and extensive compilation of synthetic strategies, mechanism of action, and the structure-activity relationship thereof for the management of lung carcinoma.

Cite this article as:

Kumar Manvendra , Singla Ramit , Dandriyal Jyoti and Jaitak Vikas *, Coumarin Derivatives as Anticancer Agents for Lung Cancer Therapy: A Review, Anti-Cancer Agents in Medicinal Chemistry 2018; 18 (7) . https://dx.doi.org/10.2174/1871520618666171229185926