Abstract
A novel synthesis of 3-(7-methylbenzo[d]oxazol-4-yl) butanoic acid as a possible precursor of (+)-seco-pseudopteroxazole and (+)-pseudopteroxazole is presented. This synthesis was performed from m-cresol where a Fries rearrangement, a nitration reaction and an olefination reaction were the key reactions to achieve the synthesis of 3-(7-methylbenzo[d]oxazol-4-yl) butanoic acid.
Keywords: (+)-seco-pseudopteroxazole, (+)-pseudopteroxazole, antituberculotic, Mycobacterium tuberculosis, nitration reaction, olefination.
Graphical Abstract
Letters in Organic Chemistry
Title:Synthesis of 3-(7-Methylbenzo[d]oxazol-4-yl) Butanoic Acid: A Precursor of (+)-seco-Pseudopteroxazole and (+)-Pseudopteroxazole
Volume: 15 Issue: 12
Author(s): Aurelio Ortiz*, Pedro Ramírez, Jacqueline Jiménez, Angel Mendoza and Estibaliz Sansinenea
Affiliation:
- Facultad de Ciencias Quimicas, Benemerita Universidad Autonoma de Puebla, Puebla 72570,Mexico
Keywords: (+)-seco-pseudopteroxazole, (+)-pseudopteroxazole, antituberculotic, Mycobacterium tuberculosis, nitration reaction, olefination.
Abstract: A novel synthesis of 3-(7-methylbenzo[d]oxazol-4-yl) butanoic acid as a possible precursor of (+)-seco-pseudopteroxazole and (+)-pseudopteroxazole is presented. This synthesis was performed from m-cresol where a Fries rearrangement, a nitration reaction and an olefination reaction were the key reactions to achieve the synthesis of 3-(7-methylbenzo[d]oxazol-4-yl) butanoic acid.
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Cite this article as:
Ortiz Aurelio *, Ramírez Pedro , Jiménez Jacqueline , Mendoza Angel and Sansinenea Estibaliz , Synthesis of 3-(7-Methylbenzo[d]oxazol-4-yl) Butanoic Acid: A Precursor of (+)-seco-Pseudopteroxazole and (+)-Pseudopteroxazole, Letters in Organic Chemistry 2018; 15 (12) . https://dx.doi.org/10.2174/1570178615666171227142301
DOI https://dx.doi.org/10.2174/1570178615666171227142301 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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