An Update of Patents, Preclinical and Clinical Outcomes of Lipid Nanoparticulate Systems

Title:An Update of Patents, Preclinical and Clinical Outcomes of Lipid Nanoparticulate Systems

Volume: 23 Issue: 43

Author(s): Kamla Pathak*, Ravi Shankar and Monika Joshi

Affiliation:

• Pharmacy College Saifai, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, 206130, Uttar Pradesh,India

Keywords: Solid lipid nanoparticles, nanostructured lipid carrier, lipid drug conjugate, patents, clinical trials, polymeric nanoparticles.

Abstract: Background: Lipid nanoparticles have attracted increased degree of scientific and commercial attention in the last decade. The lipidic nanoparticles have emerged as a potential alternative to other nano-scale systems due to their various advantages over them and also due to overcoming the shortcomings of the already available colloidal systems like liposomes, niosomes and polymeric nanoparticles.

Description: These have been investigated for delivery of macromolecules, genes, siRNA and other therapeutic agents for oral, topical, parenteral administration and target site specific delivery for various diseases like cancer, ocular diseases and brain disorders. The lipid nanoparticles have evolved from SLNs, then NLCs and lipid drug conjugates overcoming any issues related to production and formulation and adding advantages, if any. The current review article focuses on the lipid nanoparticles, their formulation approaches and current advancements in the field through recent clinical trials and patents. This manuscript embodies various patents, preclinical and clinical aspects related to the lipidic nanocarriers.

Conclusion: Over the years the lipidic nanoparticulate systems have evolved as significant carriers for improved therapeutics and in diagnostic field. The large number of patents and preclinical trials in the recent years suggests that these systems will find immense potential in near future.

Cite this article as:

Pathak Kamla *, Shankar Ravi and Joshi Monika , An Update of Patents, Preclinical and Clinical Outcomes of Lipid Nanoparticulate Systems, Current Pharmaceutical Design 2017; 23 (43) . https://dx.doi.org/10.2174/1381612823666171122104216