Abstract
Malignant melanoma is a very aggressive form of skin cancer, with increasing rates every year, with an etiology that derives from the transformation and uncontrolled growth of melanocytes. There are several treatment options which can be used as unique treatment or combined, depending upon the stage of melanoma including surgical excision, chemotherapy, immunotherapy, targeted therapy. Plant Kingdom displays an unequalled potential for the synthesis of highly diversified chemical structures. Although natural compounds are synthesized in order to help the plant to interact with the environment, a large number of phytochemicals act as drugs within the human or animal body by activating various biochemical pathways. The study aims to review another approach in the management of this highly aggressive form of skin cancer, namely the effect of natural compounds in the chemoprevention of malignant melanoma.
Keywords: Malignant melanoma, natural compounds, chemoprevention, skin cancer, melanocytes, biochemical pathways.
Graphical Abstract
Anti-Cancer Agents in Medicinal Chemistry
Title:Natural Compounds in the Chemoprevention of Malignant Melanoma
Volume: 18 Issue: 5
Author(s): Corina Danciu*, Codruta Soica, Diana Antal, Ersilia Alexa, Ioana Z. Pavel, Roxana Ghiulai, Florina Ardelean, Roxana M. Babuta, Alexandra Popescu and Cristina A. Dehelean
Affiliation:
- Department of Pharmacognosy, Faculty of Pharmacy, ,Romania
Keywords: Malignant melanoma, natural compounds, chemoprevention, skin cancer, melanocytes, biochemical pathways.
Abstract: Malignant melanoma is a very aggressive form of skin cancer, with increasing rates every year, with an etiology that derives from the transformation and uncontrolled growth of melanocytes. There are several treatment options which can be used as unique treatment or combined, depending upon the stage of melanoma including surgical excision, chemotherapy, immunotherapy, targeted therapy. Plant Kingdom displays an unequalled potential for the synthesis of highly diversified chemical structures. Although natural compounds are synthesized in order to help the plant to interact with the environment, a large number of phytochemicals act as drugs within the human or animal body by activating various biochemical pathways. The study aims to review another approach in the management of this highly aggressive form of skin cancer, namely the effect of natural compounds in the chemoprevention of malignant melanoma.
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Danciu Corina *, Soica Codruta , Antal Diana, Alexa Ersilia , Pavel Z. Ioana , Ghiulai Roxana , Ardelean Florina , Babuta M. Roxana, Popescu Alexandra and Dehelean A. Cristina, Natural Compounds in the Chemoprevention of Malignant Melanoma, Anti-Cancer Agents in Medicinal Chemistry 2018; 18 (5) . https://dx.doi.org/10.2174/1871520617666171121142522
DOI https://dx.doi.org/10.2174/1871520617666171121142522 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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