Metabolic Syndrome and Cardiovascular Risk in People Treated with Long-Acting Injectable Antipsychotics

Title:Metabolic Syndrome and Cardiovascular Risk in People Treated with Long-Acting Injectable Antipsychotics

Volume: 18 Issue: 4

Author(s): Vanessa Sanchez-Martinez*, Dolores Romero-Rubio, Maria Jose Abad-Perez, Maria Amparo Descalzo-Cabades, Sofia Alonso-Gutierrez, Jose Salazar-Fraile, Vicente Montagud and Lorenzo Facila

Affiliation:

• Department of Nursing, Faculty of Nursing and Chiropody, University of Valencia, Valencia,Spain

Keywords: Metabolic syndrome, cardiovascular risk, severe mental disorders, long-acting injectable antipsychotics, outpatients, gender differences.

Abstract: Background: People with schizophrenia and other severe mental disorders have an increased mortality mainly attributed to natural causes, specifically cardiovascular disease and cancer. The metabolic syndrome and the Framingham Risk Score are epidemiologic tools related to long-term cardiovascular disease risk and they are increased in people with severe mental disorders. This increase has been attributed both to the disorder itself and to the use of antipsychotic drugs.

Objective: To quantify the cardiovascular risk in a group of people treated with long-acting injectable antipsychotics.

Methods: This is a cross-sectional study developed in an outpatient mental health clinic in which the prevalence of metabolic syndrome was estimated and the cardiovascular risk was measured using the Framingham Risk Score. All the analyses were separated by gender.

Results: 130 people (81 men) were recruited. According to the International Diabetes Federation criteria, 60 participants (46,2%) had metabolic syndrome. The individual criterion most often met in both genders was obesity. The mean Framingham Risk Score for the sample was moderate, 7,7 (SD: 6,3). For women, the risk was lower (mean 5,7, SD: 4,9) than for men (mean=9, SD: 6,7). There were no significant differences in the prevalence of metabolic syndrome and Framingham Risk Scores by longacting injectable antipsychotic or years of treatment.

Conclusion: The prevalence of metabolic syndrome and the cardiovascular risk are high in people with psychosis treated with long acting injectable antipsychotics. To better address this vulnerability, the recommendations involve both behavioral and pharmacological interventions.

Cite this article as:

Sanchez-Martinez Vanessa *, Romero-Rubio Dolores, Abad-Perez Jose Maria, Descalzo-Cabades Amparo Maria , Alonso-Gutierrez Sofia , Salazar-Fraile Jose, Montagud Vicente and Facila Lorenzo , Metabolic Syndrome and Cardiovascular Risk in People Treated with Long-Acting Injectable Antipsychotics, Endocrine, Metabolic & Immune Disorders - Drug Targets 2018; 18 (4) . https://dx.doi.org/10.2174/1871530317666171120151201