Abstract
Background: Numerous studies indicate that statins have multiple beneficial actions (known as ‘pleiotropic actions') on cardiovascular system through the improvement of endothelial dysfunction, inflammation, oxidative stress, excessive arterial thrombosis, and stabilization of the atherosclerotic plaque. Aortic disease primarily consists of aortic valve stenosis, aortic valve regurgitation, aneurysm disease, and genetic disorders such as Marfan syndrome, bicuspid aortic valve and aortic coarctation. Many studies have revealed the cardioprotective actions of statins in aortic disease.
Objective: Our aim was to present current data concerning the value of treatment with statins in aortic diseases.
Methods: A thorough search of PubMed and the Cochrane Database was conducted to identify the studies and novel articles related to the use of statins in aortic disease.
Results: Numerous studies in animals and humans indicate a beneficial effect of treatment with statins in the previous conditions apart from a few conflicting data.
Conclusion: There is a need of further investigation in this field, especially for the estimation of the optimal type and dose of statins required in each clinical condition of aortic disease.
Keywords: Aortic disease, cardiovascular diseases, HMG-CoA- inhibitors, inflammation, statins, endothelial dysfunction.
Current Pharmaceutical Design
Title:Statins in Aortic Disease
Volume: 23 Issue: 46
Author(s): Vasiliki Tsigkou, Gerasimos Siasos*, Evanthia Bletsa, Maria-Paraskevi Panoilia, Angeliki Papastavrou, Georgios Kokosias, Evangelos Oikonomou, Marina Zaromitidou, Manolis Vavuranakis, Christodoulos Stefanadis and Dimitris Tousoulis
Affiliation:
- Department of Cardiology, ‘Hippokration' General Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens,Greece
Keywords: Aortic disease, cardiovascular diseases, HMG-CoA- inhibitors, inflammation, statins, endothelial dysfunction.
Abstract: Background: Numerous studies indicate that statins have multiple beneficial actions (known as ‘pleiotropic actions') on cardiovascular system through the improvement of endothelial dysfunction, inflammation, oxidative stress, excessive arterial thrombosis, and stabilization of the atherosclerotic plaque. Aortic disease primarily consists of aortic valve stenosis, aortic valve regurgitation, aneurysm disease, and genetic disorders such as Marfan syndrome, bicuspid aortic valve and aortic coarctation. Many studies have revealed the cardioprotective actions of statins in aortic disease.
Objective: Our aim was to present current data concerning the value of treatment with statins in aortic diseases.
Methods: A thorough search of PubMed and the Cochrane Database was conducted to identify the studies and novel articles related to the use of statins in aortic disease.
Results: Numerous studies in animals and humans indicate a beneficial effect of treatment with statins in the previous conditions apart from a few conflicting data.
Conclusion: There is a need of further investigation in this field, especially for the estimation of the optimal type and dose of statins required in each clinical condition of aortic disease.
Export Options
About this article
Cite this article as:
Tsigkou Vasiliki, Siasos Gerasimos *, Bletsa Evanthia , Panoilia Maria-Paraskevi, Papastavrou Angeliki , Kokosias Georgios , Oikonomou Evangelos, Zaromitidou Marina , Vavuranakis Manolis, Stefanadis Christodoulos and Tousoulis Dimitris, Statins in Aortic Disease, Current Pharmaceutical Design 2017; 23 (46) . https://dx.doi.org/10.2174/1381612823666171115100829
DOI https://dx.doi.org/10.2174/1381612823666171115100829 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Lifestyle Factors and Endothelial Function
Current Vascular Pharmacology Contemporary Management of Hypertension - How to Optimize Therapy
Cardiovascular & Hematological Disorders-Drug Targets Mid-Aortic Syndrome: A Rare Cause of Renovascular Hypertension in Childhood Treated Percutaneously with an Unusual Vascular Access
Current Pediatric Reviews Neurocognitive Monitoring and Care During Pediatric Cardiopulmonary Bypass — Current and Future Directions
Current Cardiology Reviews Vascular Arginase and Hypertension
Current Hypertension Reviews Toxic Effects of Aflatoxin B1 on Embryonic Development of Zebrafish (Danio rerio): Potential Activity of Piceatannol Encapsulated Chitosan/poly (Lactic Acid) Nanoparticles
Anti-Cancer Agents in Medicinal Chemistry The Anti-Inflammatory Effects of Statins on Coronary Artery Disease: An Updated Review of the Literature
Current Cardiology Reviews Arterial Dilatation-Related Diseases: The Prerequisite Condition of Arterial Elastic Tissue Damage and Endovascular Treatment
Recent Patents on Medical Imaging Pediatrics for Disability: A Comprehensive Approach to Children with Syndromic Psychomotor Delay
Current Pediatric Reviews Current Management of Traumatic Rupture of the Descending Thoracic Aorta
Current Cardiology Reviews Respiratory Gas Exchange During Exercise in Children with Congenital Heart Disease: Methodology and Clinical Concepts
Current Respiratory Medicine Reviews The Coronary Circulation in Arterial Hypertension
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Medical and Dental Implications of Down Syndrome: A Review Part 1: General and Craniofacial Characteristic
Applied Clinical Research, Clinical Trials and Regulatory Affairs Secondary Hypertension: The Ways of Management
Current Vascular Pharmacology Zebrafish: A Complete Animal Model for In Vivo Drug Discovery and Development
Current Drug Metabolism Current Management of Vascular Tumors in the Neonate
Current Pediatric Reviews Is Peri-Operative Isolated Systolic Hypertension (ISH) a Cardiac Risk Factor?
Current Cardiology Reviews Effects of ACE-Inhibitors and Angiotensin Receptor Blockers on Inflammation
Current Pharmaceutical Design A Review of Selected Adult Congenital Heart Diseases Encountered in Daily Practice
Current Cardiology Reviews Respiratory Syncytial Virus (RSV) Prevention and Treatment: Past, Present, and Future
Cardiovascular & Hematological Agents in Medicinal Chemistry