Abstract
Accumulating evidence has shown the importance of glial cells in the neurobiology of bipolar disorder. Activated microglia and inflammatory cytokines have been pointed out as potential biomarkers of bipolar disorder. Indeed, recent studies have shown that bipolar disorder involves microglial activation in the hippocampus and alterations in peripheral cytokines, suggesting a potential link between neuroinflammation and peripheral toxicity. These abnormalities may also be the biological underpinnings of outcomes related to neuroprogression, such as cognitive impairment and brain changes. Additionally, astrocytes may have a role in the progression of bipolar disorder, as these cells amplify inflammatory response and maintain glutamate homeostasis, preventing excitotoxicity. The present review aims to discuss neuron-glia interactions and their role in the pathophysiology and treatment of bipolar disorder.
Keywords: Bipolar disorder, mania, neuron, glia, microglia, astrocyte, oligodendrocyte, brain-blood barrier.
Graphical Abstract
Current Neuropharmacology
Title:Neuron-glia Interaction as a Possible Pathophysiological Mechanism of Bipolar Disorder
Volume: 16 Issue: 5
Author(s): Jairo Vinicius Pinto, Ives Cavalcante Passos, Diego Librenza-Garcia, Grasiela Marcon, Maiko Abel Schneider, Joao Henrique Conte, Joao Pedro Abreu da Silva, Luiza Pereira Lima, Andre Quincozes-Santos, Marcia Kauer-Sant`Anna and Flavio Kapczinski*
Affiliation:
- Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON,Canada
Keywords: Bipolar disorder, mania, neuron, glia, microglia, astrocyte, oligodendrocyte, brain-blood barrier.
Abstract: Accumulating evidence has shown the importance of glial cells in the neurobiology of bipolar disorder. Activated microglia and inflammatory cytokines have been pointed out as potential biomarkers of bipolar disorder. Indeed, recent studies have shown that bipolar disorder involves microglial activation in the hippocampus and alterations in peripheral cytokines, suggesting a potential link between neuroinflammation and peripheral toxicity. These abnormalities may also be the biological underpinnings of outcomes related to neuroprogression, such as cognitive impairment and brain changes. Additionally, astrocytes may have a role in the progression of bipolar disorder, as these cells amplify inflammatory response and maintain glutamate homeostasis, preventing excitotoxicity. The present review aims to discuss neuron-glia interactions and their role in the pathophysiology and treatment of bipolar disorder.
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Pinto Vinicius Jairo , Passos Cavalcante Ives, Librenza-Garcia Diego , Marcon Grasiela , Schneider Abel Maiko , Conte Henrique Joao , da Silva Pedro Abreu Joao , Lima Pereira Luiza , Quincozes-Santos Andre, Kauer-Sant`Anna Marcia and Kapczinski Flavio *, Neuron-glia Interaction as a Possible Pathophysiological Mechanism of Bipolar Disorder, Current Neuropharmacology 2018; 16 (5) . https://dx.doi.org/10.2174/1570159X15666170828170921
DOI https://dx.doi.org/10.2174/1570159X15666170828170921 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
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