The Application of the Cold Atmospheric Plasma-Activated Solutions in Cancer Treatment

Title:The Application of the Cold Atmospheric Plasma-Activated Solutions in Cancer Treatment

Volume: 18 Issue: 6

Author(s): Dayun Yan*, Jonathan H. Sherman and Michael Keidar*

Affiliation:

• Department of Mechanical and Aerospace Engineering, The George Washington University, Science & Engineering Hall, 800 22nd Street, NW, Room 3550, Washington, DC 20052,United States

• Department of Mechanical and Aerospace Engineering, The George Washington University, Science & Engineering Hall, 800 22nd Street, NW, Room 3550, Washington, DC 20052,United States

Keywords: Plasma, cold atmospheric plasma, cancer cells, cancer treatment, reactive nitrogen species, reactive oxygen species.

Abstract: Background: Over the past five years, the cold atmospheric plasma-activated solutions (PAS) have shown their promissing application in cancer treatment. Similar as the common direct cold plasma treatment, PAS shows a selective anti-cancer capacity in vitro and in vivo. However, different from the direct cold atmospheric plasma (CAP) treatment, PAS can be stored for a long time and can be used without dependence on a CAP device. The research on PAS is gradually becoming a hot topic in plasma medicine.

Objectives: In this review, we gave a concise but comprehensive summary on key topics about PAS including the development, current status, as well as the main conclusions about the anti-cancer mechanism achieved in past years. The approaches to make strong and stable PAS are also summarized.

Cite this article as:

Yan Dayun *, Sherman H. Jonathan and Keidar Michael*, The Application of the Cold Atmospheric Plasma-Activated Solutions in Cancer Treatment, Anti-Cancer Agents in Medicinal Chemistry 2018; 18 (6) . https://dx.doi.org/10.2174/1871520617666170731115233