Renin-Angiotensin System in Diabetes

Title:Renin-Angiotensin System in Diabetes

Volume: 24 Issue: 9

Author(s): Johannes Rein and Michael Bader*

Affiliation:

• Max-Delbruck-Center for Molecular Medicine, Robert-Rossle-Str. 10, 13125 Berlin,Germany

Keywords: Renin-angiotensin system, effector peptide angiotensin, pathogenesis, diabetes mellitus, drugs, therapy.

Abstract: The renin-angiotensin system (RAS) has two different axes, the classical one with the effector peptide angiotensin II and the new one with the effector peptide angiotensin (1-7). Both peptides have been shown to be involved in the pathogenesis of diabetes mellitus and its consequences, nephropathy, retinopathy and cardiomyopathy in animal models and patients. In diabetes, angiotensin II acts mostly deleterious and angiotensin (1-7) protective. In this review we summarize the knowledge about the role of the different RAS axes in diabetes mellitus and the use of drugs interfering with the RAS in the therapy of the disease.

Cite this article as:

Rein Johannes and Bader Michael *, Renin-Angiotensin System in Diabetes, Protein & Peptide Letters 2017; 24 (9) . https://dx.doi.org/10.2174/0929866524666170728144357

DOI https://dx.doi.org/10.2174/0929866524666170728144357	Print ISSN 0929-8665
Publisher Name Bentham Science Publisher	Online ISSN 1875-5305