Phosphonium Salt Displays Cytotoxic Effects Against Human Cancer Cell Lines

Title:Phosphonium Salt Displays Cytotoxic Effects Against Human Cancer Cell Lines

Volume: 17 Issue: 13

Author(s): Dhanyalayam Dhanya, Palma Giuseppe*, Cappello A. Rita*, Mariconda Annaluisa, Sinicropi M. Stefania, Giordano Francesca, Vitale Del Vecchio, Ramunno Anna, Arra Claudio, Longo Pasquale and Saturnino Carmela

Affiliation:

• SSD Sperimentazione Animale, Istituto Nazionale Tumori, IRCCS, Fondazione “G. Pascale”, Naples,Italy

• Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Rende (CS),Italy

Keywords: Lipophilic phosphonium salts, Human tumor cell lines, anticancer drugs, reactive oxygen species, mitochondria, cell cycle.

Abstract: Aims/Objective: Phosphonium salts are compounds whose structural characteristics enable them to cross the plasma and mitochondrial membrane with ease. Cancer cells have higher plasma membrane potentials than normal cells; phosphonium salts selectively accumulate in the mitochondria of neoplastic cells and inhibit mitochondrial function.

Method: In the present work, we investigated the cytotoxic activity of lipophilic phosphonium salt (11- methoxy11-oxo-undecyl) triphenylphosphonium bromide (MUTP) as well as of the two new phosphine oxide salts, 3,3'-(methylphosphoryl) dibenzenaminium chloride (SBAMPO) and 3,3' (phenylphosphoryl) dibenzenaminium chloride (SBAPPO) on the proliferation of breast cancer cell line (MCF-7) and human uterin cervix adenocarcinoma cells (HeLa).

Result: We showed that only MUTP exhibits antiproliferative effects on both cell lines, without affecting the normal breast epithelial cell proliferation. More specifically, we demonstrated that MUTP treatment of breast cancer cells is associated with impaired cell-cycle progression and metabolically induces mitochondrial damage and triggers apoptotic cell death in MCF-7 and HeLa cells. Taken together, these findings suggest that MUTP may be capable of selectively targeting neoplastic cell growth and therefore has potential applications as anticancer agent.

Cite this article as:

Dhanya Dhanyalayam , Giuseppe Palma *, Rita A. Cappello *, Annaluisa Mariconda , Stefania M. Sinicropi , Francesca Giordano , Del Vecchio Vitale, Anna Ramunno , Claudio Arra , Pasquale Longo and Carmela Saturnino , Phosphonium Salt Displays Cytotoxic Effects Against Human Cancer Cell Lines, Anti-Cancer Agents in Medicinal Chemistry 2017; 17 (13) . https://dx.doi.org/10.2174/1871520617666170719154249