Dual Roles of Pin1 in Cancer Development and Progression

Title:Dual Roles of Pin1 in Cancer Development and Progression

Volume: 23 Issue: 29

Author(s): Hyeong-jun Han, Bu Young Choi and Young-Joon Surh*

Affiliation:

• Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University, Seoul 08826,Korea

Keywords: Pin1, proline-directed protein kinases, phosphorylation-dependent peptidyl-prolyl isomerase, pSer/Thr-Pro motif, PPIase, proline isomerization.

Abstract: Pin1 is a unique peptidyl-prolyl cis/trans isomerase (PPIase) that catalyzes the cis/trans isomerization of peptidyl-prolyl peptide bonds of its substrate proteins by binding to their specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs. This alters the conformation of target proteins and consequently affects their stability, intracellular localization, and/or biological functions. The abnormal overexpression of Pin1 is observed in some malignancies, which is associated with cancer cell proliferation, migration and invasion. However, a role for Pin1 as a putative tumor suppressor has recently been suggested. Systematic dissection of pro-oncogenic vs. tumor suppressive functions of Pin1 will be necessary.

Cite this article as:

Han Hyeong-jun , Choi Young Bu and Surh Young-Joon *, Dual Roles of Pin1 in Cancer Development and Progression, Current Pharmaceutical Design 2017; 23 (29) . https://dx.doi.org/10.2174/1381612823666170703164711