Clinically Relevant Biomarkers in Acute Heart Failure: An Update

Title:Clinically Relevant Biomarkers in Acute Heart Failure: An Update

Volume: 18 Issue: 6

Author(s): Agnibh Mukherji*, Uzair Ansari, Martin Borggrefe, Ibrahim Akin and Michael Behnes

Affiliation:

• First Department of Medicine, University Medical Centre Mannheim (UMM), Faculty of Medicine Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim,Germany

Keywords: Acute heart failure, natriuretic peptides, myocardial injury, neurohormonal activation markers, myocardial remodeling markers, CTGF.

Abstract: Background: Acute Heart Failure (AHF), owing to the difficulties in diagnosis, prognostic stratification and patient-related management, is still associated with unusually high morbidity and mortality. The advent of novel biomarkers apart from natriuretic peptides involved in myocardial injury, neuro-hormonal activation, and ventricular remodeling augurs immense hope in redefining the biomarker-based approach towards AHF.

Methods: A thorough review of the available literature including latest review articles from distinguished experts, textbook references and guidelines from leading cardiological societies worldwide as well as the latest trials, encompassing various biomarkers known in AHF was conducted. The most relevant ones were chosen as references for the current review article.

Results: Biomarkers such as midregional proatrial natriuretic peptide, soluble ST2, highly-sensitive troponin, and midregional proadrenomedullin are some such examples that have passed various stages of substantiation while there is an array of potential biomarkers innascent stages like osteopontin, CTGF, GDF-15 and TGF beta-1 awaiting further reiteration. Not only the diagnosis of AHF itself but the evaluation of co-morbidities using markers like PCT, hematologic markers or acute kidney injury markers like NGAL present a new perspective to the management of AHF.

Conclusion: This review article outlines the current status of the most relevant cardiac biomarkers related to AHF.

Cite this article as:

Mukherji Agnibh *, Ansari Uzair , Borggrefe Martin , Akin Ibrahim and Behnes Michael , Clinically Relevant Biomarkers in Acute Heart Failure: An Update, Current Pharmaceutical Biotechnology 2017; 18 (6) . https://dx.doi.org/10.2174/1389201018666170623090817

DOI https://dx.doi.org/10.2174/1389201018666170623090817	Print ISSN 1389-2010
Publisher Name Bentham Science Publisher	Online ISSN 1873-4316