Targeted Nanosystems for Cancer Therapy

Title:Targeted Nanosystems for Cancer Therapy

Volume: 13 Issue: 1

Author(s): Ruhee Jain, Tahseen Khan, Sourabh Jain, Ashutosh Pal Jain and Aakanchha Jain*

Affiliation:

• Bhagyoday Tirth Pharmacy College, Sagar (M.P.), 470002,India

Keywords: Chemotherapeutics, clinical trials, dendrimers, fullerenes, liposomes, nanocarriers.

Abstract: Background: Significant shortcomings have been displayed in conventional chemotherapeutics delivery which possesses some genuine side effects including harm of the immunity and different organs with quickly multiplying cells because of nonparticular focus on the absence of dissolvability and powerlessness to enter the tumor core bringing about debilitated treatment with diminished dosage and with low survival rate. Rapid development has adapted nanocarriers as distinct therapeutics which can directly access the tumor cells specifically with expanded medication limitation and cell take-up for cancer treatment.

Methodology: This review focuses on core objective of drug targeting to the cancerous cells by demonstrating the advantages of the young medical field, “nanocarriers” including liposomes, polymer based nanoparticles, metal based nanoparticles, dendrimers, protein linked systems, co-polymers and fullerenes, which have been proven remarkably promising in enhancing drug distribution and bioavailability, increasing half life and achieving targeted drug delivery, thus reducing toxicity.

Conclusion: Here we provide an update on the recent clinical trials in nanocarrier based therapy of colon rectal cancer, food and drug administration (FDA) approved nanomedicines for cancer and those in nanoplatforms which have reached an advanced stage of clinical development.

Cite this article as:

Jain Ruhee , Khan Tahseen , Jain Sourabh, Jain Pal Ashutosh and Jain Aakanchha *, Targeted Nanosystems for Cancer Therapy, Current Cancer Therapy Reviews 2017; 13 (1) . https://dx.doi.org/10.2174/1573394713666170622104347

DOI https://dx.doi.org/10.2174/1573394713666170622104347	Print ISSN 1573-3947
Publisher Name Bentham Science Publisher	Online ISSN 1875-6301