Vitamin D Metabolism and Potential Effects of Vitamin D Receptor Modulation in Chronic Kidney Disease

Title:Vitamin D Metabolism and Potential Effects of Vitamin D Receptor Modulation in Chronic Kidney Disease

Volume: 18 Issue: 7

Author(s): Antonio Bellasi*, Andrea Galassi, Michela Mangano, Luca Di Lullo and Mario Cozzolino

Affiliation:

• Renal and Dialysis Division Ospedale Sant’Anna-Como, ASST-Lariana, Via Ravona, 20 – 22020 Como,Italy

Keywords: CKD-MBD, vitamin D, paracalcitol, Vitamin D receptor, vitamin D deficiency.

Abstract: Background: Vitamin D deficiency is one determinant of secondary hyperparathyroidism in the course of Chronic Kidney Disease (CKD). However, numerous studies support the notion that vitamin D may exert pleiotropic effects aside of mineral metabolism control. Indeed, vitamin D receptor has been identified in a great variety of tissues and its activation contributes to the parathyroid, intestine, cardiovascular and immune system regulation.

Cite this article as:

Bellasi Antonio *, Galassi Andrea, Mangano Michela , Di Lullo Luca and Cozzolino Mario , Vitamin D Metabolism and Potential Effects of Vitamin D Receptor Modulation in Chronic Kidney Disease, Current Drug Metabolism 2017; 18 (7) . https://dx.doi.org/10.2174/1389200218666170427112735