Abstract
Introduction: Transplantation of autologous mesenchymal stem cells (MSCs) has been shown to attenuate renal injury and dysfunction in several animal models, and its efficacy is currently being tested in clinical trials for patients with renal disease. Accumulating evidence indicates that MSCs release extracellular vesicles (EVs) that deliver genes, microRNAs and proteins to recipient cells, acting as mediators of MSC paracrine actions. In this context, it is critical to characterize the MSC-derived EV cargo to elucidate their potential contribution to renal repair. In recent years, researchers have performed high-throughput sequencing and proteomic analysis to detect and identify genes, microRNAs, and proteins enriched in MSC-derived EVs.
Conclusion: The present review summarizes the current knowledge of the MSC-derived EV secretome to shed light into the mechanisms mediating MSC renal repair, and discusses preclinical and clinical studies testing the efficacy of MSC-derived EVs for treating renal disease.Keywords: Exosomes, extracellular vesicles, kidney, mesenchymal stem cells, microRNA, microvesicles.
Current Gene Therapy
Title:Mesenchymal Stem Cell-derived Extracellular Vesicles for Renal Repair
Volume: 17 Issue: 1
Author(s): Arash Aghajani Nargesi, Lilach O. Lerman and Alfonso Eirin*
Affiliation:
- Division of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905,United States
Keywords: Exosomes, extracellular vesicles, kidney, mesenchymal stem cells, microRNA, microvesicles.
Abstract: Introduction: Transplantation of autologous mesenchymal stem cells (MSCs) has been shown to attenuate renal injury and dysfunction in several animal models, and its efficacy is currently being tested in clinical trials for patients with renal disease. Accumulating evidence indicates that MSCs release extracellular vesicles (EVs) that deliver genes, microRNAs and proteins to recipient cells, acting as mediators of MSC paracrine actions. In this context, it is critical to characterize the MSC-derived EV cargo to elucidate their potential contribution to renal repair. In recent years, researchers have performed high-throughput sequencing and proteomic analysis to detect and identify genes, microRNAs, and proteins enriched in MSC-derived EVs.
Conclusion: The present review summarizes the current knowledge of the MSC-derived EV secretome to shed light into the mechanisms mediating MSC renal repair, and discusses preclinical and clinical studies testing the efficacy of MSC-derived EVs for treating renal disease.Export Options
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Cite this article as:
Nargesi Aghajani Arash, Lerman O. Lilach and Eirin Alfonso*, Mesenchymal Stem Cell-derived Extracellular Vesicles for Renal Repair, Current Gene Therapy 2017; 17 (1) . https://dx.doi.org/10.2174/1566523217666170412110724
DOI https://dx.doi.org/10.2174/1566523217666170412110724 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
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