Synthesis, Characterization and Comparison of Local Analgesic, Anti-Inflammatory, Anti-Ulcerogenic Activity of Copper and Zinc Complexes of Indomethacin

Title:Synthesis, Characterization and Comparison of Local Analgesic, Anti-Inflammatory, Anti-Ulcerogenic Activity of Copper and Zinc Complexes of Indomethacin

Volume: 15 Issue: 3

Author(s): Abhijit Sukul*, Saikat Kumar Poddar, Sanjana Haque, Sajal Kumar Saha, Sreedam Chandra Das, Zobaer Al Mahmud and S. M. Abdur Rahman

Affiliation:

• Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka-1000, Bangladesh, and Department of Pharmacy, Northern University Bangladesh, Dhaka-1205,Bangladesh

Keywords: Anti-inflammatory, differential scanning calorimetry, indomethacin metal complexes, local analgesic, spectroscopy, anti-ulcerogenic activity.

Abstract: Background: Non-steroidal anti-inflammatory drugs (NSAID) exert gastrointestinal upset by inhibiting mucosal cyclooxygenase (COX) activity and complexation technique with metals has been adopted to overcome this drawback.

Objective: The study aimed to overcome the gastrointestinal side effects associated with indomethacin treatment by synthesizing copper (Cu) and zinc (Zn) complexes of indomethacin along with assessing potential pharmacological effects of these complexes.

Method: The characterization of synthesized complexes was done by FT-IR, XRD, UV-Vis, Atomic Absorption Spectroscopy (AAS) and Differential Scanning Calorimetry (DSC). Biological properties as local analgesic activity, anti-inflammatory activity and antiulcerogenic activity were evaluated following radiant heat tail flick, inhibition of rat hind paw edema and inhibition of NSAID induced gastroenteropathy method respectively.

Results: 0.3 ml of indomethacin-copper complex demonstrated prominent analgesia at 25 µg/ml dose and 0.3 ml of indomethacin-zinc complex, after 30, 60 and 90 minutes of oral administration, shown significant local analgesia at 25, 50 and 100 µg/ml dose. In antiinflammatory activity assay, indomethacin-copper exhibited significant inhibition at 20 mg/kg dose after 2nd, 3rd and 4th hour of administration whereas indomethacin-zinc illustrated significant inhibition at 10 mg/kg dose after 2nd, 3rd and 4th hour of administration. Anti-ulcerogenic activity study of the complexes exhibited no macroscopic damage to the stomach and intestine, except minor microscopic damage.

Conclusion: In view of the results, the copper and zinc complexes of indomethacin may be used as better substitutes of the parent indomethacin owing to their minimal side effects with additional pharmacological effects.

Cite this article as:

Sukul Abhijit*, Poddar Kumar Saikat, Haque Sanjana, Saha Kumar Sajal, Das Chandra Sreedam, Al Mahmud Zobaer and Abdur Rahman M. S., Synthesis, Characterization and Comparison of Local Analgesic, Anti-Inflammatory, Anti-Ulcerogenic Activity of Copper and Zinc Complexes of Indomethacin, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2016; 15 (3) . https://dx.doi.org/10.2174/1871523016666170217103402

DOI https://dx.doi.org/10.2174/1871523016666170217103402	Print ISSN 1871-5230
Publisher Name Bentham Science Publisher	Online ISSN 1875-614X