A Retrospective Study of Drug Induced Cutaneous Adverse Reactions (CADR) in Patients Attending a Tertiary Care Hospital

Title:A Retrospective Study of Drug Induced Cutaneous Adverse Reactions (CADR) in Patients Attending a Tertiary Care Hospital

Volume: 12 Issue: 1

Author(s): Khyati Doshi, Radha Yegnanarayan and Neeta Gokhale

Affiliation:

Keywords: Adverse cutaneous drug reactions, Antimicrobials, NSAIDS, Urticaria.

Abstract: Objectives: Find possible causative agents causing cutaneous adverse reactions; clinical patterns, causality and severity of Drug induced cutaneous adverse reactions (CADR) and treatment outcome.

Methods: Retrospective study was undertaken including cases of CADR. Causality, preventability and severity of Drug Induced cutaneous reactions were judged with the use of Naranjo's algorithm, WHO causality scale, modified Schumock and Thorton scale, and Hartwig’s scale respectively.

Results: Among 275 total cADRs reported, Antimicrobials (46.55%) were the main drugs involved followed by Non steroidal anti-inflammatory drugs (NSAIDs) (25.09%) and Antifungal (9.82%). Urticaria (63.64%) followed by Erythema multiform(12.36%) was most frequently observed CDRs. Amongst all cADRs 50.18% were certain according to Naranjo’s scale, none of them were preventable according to modified Schumock and Thorton scale. All reactions were moderate according to Hartwig’s severity scale.

Conclusion: It was observed that antibiotics and NSAIDs cause maximum number of CADRs. Therefore strict vigilance is required while using them.

Cite this article as:

Doshi Khyati, Yegnanarayan Radha and Gokhale Neeta, A Retrospective Study of Drug Induced Cutaneous Adverse Reactions (CADR) in Patients Attending a Tertiary Care Hospital, Current Drug Safety 2017; 12 (1) . https://dx.doi.org/10.2174/157488631201170210194817

DOI https://dx.doi.org/10.2174/157488631201170210194817	Print ISSN 1574-8863
Publisher Name Bentham Science Publisher	Online ISSN 2212-3911