Abstract
3-(Monosubstituted)alkylideneoxindoles as one major part of the oxindoles are involved in many essential biologically active compounds, like as self-germination and tyrosine kinase inhibitors. They have been extensively used as starting materials for the synthesis of a large number of different heterocycles. The aim of this review is to give an overview of diverse methodologies that have been developed for the construction of 3-methylene and 3-(monosubstituted)alkylideneoxindoles and their utility in organic synthesis, highlighting the variety of compounds that can be directly accessed from single reactions over these systems and emphasizing the influence of the reaction conditions in the outcome of the transformations. The reactions are classified into three main categories: one-component, two-component, and multicomponent reactions.
Keywords: Oxindoles, 3-(monosubstituted)alkylideneoxindoles, spirooxindole, biological activity, Michael addition, Diels-Alder reaction, heterocycles.
Graphical Abstract
Current Organic Chemistry
Title:Application of 3-methylene- and 3-(monosubstituted)alkylideneoxindoles in the Synthesis of Heterocyclic Compounds
Volume: 21 Issue: 14
Author(s): Abdolali Alizadeh*, Fahimeh Bayat and Leila Moafi
Affiliation:
- Department of Chemistry, School of Sciences, Tarbiat Modares University, P.O. Box: 14115-175, Tehran,Iran
Keywords: Oxindoles, 3-(monosubstituted)alkylideneoxindoles, spirooxindole, biological activity, Michael addition, Diels-Alder reaction, heterocycles.
Abstract: 3-(Monosubstituted)alkylideneoxindoles as one major part of the oxindoles are involved in many essential biologically active compounds, like as self-germination and tyrosine kinase inhibitors. They have been extensively used as starting materials for the synthesis of a large number of different heterocycles. The aim of this review is to give an overview of diverse methodologies that have been developed for the construction of 3-methylene and 3-(monosubstituted)alkylideneoxindoles and their utility in organic synthesis, highlighting the variety of compounds that can be directly accessed from single reactions over these systems and emphasizing the influence of the reaction conditions in the outcome of the transformations. The reactions are classified into three main categories: one-component, two-component, and multicomponent reactions.
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Cite this article as:
Alizadeh Abdolali*, Bayat Fahimeh and Moafi Leila, Application of 3-methylene- and 3-(monosubstituted)alkylideneoxindoles in the Synthesis of Heterocyclic Compounds, Current Organic Chemistry 2017; 21 (14) . https://dx.doi.org/10.2174/1385272821666170127153449
DOI https://dx.doi.org/10.2174/1385272821666170127153449 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Chemistry and Biology of Carbohydrates
Carbohydrates are one of the most abundant natural products and are considered to be extremely important biomolecules for their ever-increasing impact on chemistry and biology. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell ...read more
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