Momordicacharantia: A New Strategic Vision to Improve the Therapy of Endoplasmic Reticulum Stress

Title:Momordicacharantia: A New Strategic Vision to Improve the Therapy of Endoplasmic Reticulum Stress

Volume: 23 Issue: 16

Author(s): Wai Chin Chong, Rohit Gundamaraju, Ravichandra Vemuri, Marcus T. Scotti and Luciana Scotti*

Affiliation:

• Health Sciences Center, Federal University of Paraíba, Campus I, 58051-970, João Pessoa-PB,Brazil

Keywords: Endoplasmic reticulum stress, oxidative stress, momordicacharantia, radical oxidative stress, unfolded protein response, protein biosynthesis.

Abstract: Background: Endoplasmic reticulum is the major site for protein biosynthesis. Any perturbation in the endoplasmic reticulum will compromise its functions and reduce its efficiency in protein biosynthesis. As a result, misfolded proteins are produced and accumulated in the endoplasmic reticulum. This will result in endoplasmic reticulum stress, which reduces the quantity and quality of the functional protein synthesized from the cell. Besides that, the protein biosynthesis is also highly affected by oxidative stress. Oxidative stress is a condition where the cell has excessive exogenous and endogenous radical oxygen species overwhelming the human body’s antioxidant mechanisms. Recent researches have shown that endoplasmic reticulum stress has a strong relationship with oxidative stress and both of them can form a vicious cycle that exacerbates endoplasmic reticulum stress and oxidative stress. Endoplasmic reticulum stress and oxidative stress are harmful to human health since they can disrupt cellular homoeostasis and damage cells.

Cite this article as:

Chong Chin Wai, Gundamaraju Rohit, Vemuri Ravichandra, Scotti T. Marcus and Scotti Luciana*, Momordicacharantia: A New Strategic Vision to Improve the Therapy of Endoplasmic Reticulum Stress, Current Pharmaceutical Design 2017; 23 (16) . https://dx.doi.org/10.2174/1381612823666170124141104