Design and Synthesis of 1,4-dihydropyridine Derivatives as Anti-cancer Agent

Title:Design and Synthesis of 1,4-dihydropyridine Derivatives as Anti-cancer Agent

Volume: 17 Issue: 7

Author(s): Denish Viradiya, Sheefa Mirza, Faraz Shaikh, Rajesh Kakadiya*, Anand Rathod, Nayan Jain, Rakesh Rawal*Anamik Shah*

Affiliation:

• Center of Excellence, National Facility for Drug Discovery Center, Department of Chemistry, Saurashtra University, Rajkot,India

• Gujarat Cancer Research Institute, Asarwa, Ahmedabad, Gujarat,India

• Center of Excellence, National Facility for Drug Discovery Center, Department of Chemistry, Saurashtra University, Rajkot,India

Keywords: Anticancer activity, antipoliferative activity, benzylpyridinium salt, 1, 4-dihydropyridine, MTT assay.

Abstract: Aims: A series of 1,4-dihydropyridine based compounds bearing benzylpyridinium moiety have been designed and evaluated for in vitro anticancer activity against glioblastoma U87MG, lung cancer A549 and colorectal adenocarcinoma Caco-2 cell lines using the MTT assay.

Cite this article as:

Viradiya Denish, Mirza Sheefa, Shaikh Faraz, Kakadiya Rajesh*, Rathod Anand, Jain Nayan, Rawal Rakesh*, Shah Anamik*, Design and Synthesis of 1,4-dihydropyridine Derivatives as Anti-cancer Agent, Anti-Cancer Agents in Medicinal Chemistry 2017; 17 (7) . https://dx.doi.org/10.2174/1871520616666161206143251