Melissa of cinalis and Vitamin E as the Potential Therapeutic Candidates for Reproductive Toxicity Caused by Anti-cancer Drug, Cisplatin, in Male Rats

Title:Melissa of cinalis and Vitamin E as the Potential Therapeutic Candidates for Reproductive Toxicity Caused by Anti-cancer Drug, Cisplatin, in Male Rats

Volume: 12 Issue: 1

Author(s): Maryam Iman, Mostafa Araghi, Toktam Heidari and Vahid Mohammadi

Affiliation:

Keywords: Antioxidant, cisplatin, Melissa ofcinalis, reproductive toxicity, vitamin E.

Abstract: Background: High doses of Cisplatin (CP) can disrupt the normal functioning of various tissues such as ovaries and testis. In almost all the patients, spermiotoxicity of CP causes temporary or permanent azoospermia.

Objective: In this study, the defensive effect of Melissa ofcinalis and vitamin E against testicular injuries caused by CP in male rats was evaluated.

Method: Thirty six male rats were distributed into 6 groups. Group 1 was used as the negative control. In group 2, a single dose of CP (10 mg/kg) was administered on the first day. In groups 3 and 4, a single dose of CP (10 mg/kg) was administered on the first day and then treated with Melissa ofcinalis at 1000 mg/kg/day and vitamin E at 100 mg/kg/day for 7 consecutive days, respectively. Groups 5 and 6 were treated with Melissa ofcinalis and vitamin E for 7 consecutive days, respectively. After euthanasia, serum levels of testosterone, Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH) were evaluated. Testes were removed and weighed. Spermatic analysis was done on the tail of the epididymis. Tissue lipid peroxidation and activity of antioxidant enzymes in testes were evaluated as well.

Results: The results showed that Melissa ofcinalis and vitamin E increased serum levels of testosterone, LH and FSH, weight of testes and sperm motility, count and vitality and decreased sperm cell abnormalities in rats given CP.

Conclusion: Our results are useful in designing a medication of Melissa ofcinalis that can protect the testes against CP-induced testicular damage and infertility in cancerous male patients.

Cite this article as:

Iman Maryam, Araghi Mostafa, Heidari Toktam and Mohammadi Vahid, Melissa of cinalis and Vitamin E as the Potential Therapeutic Candidates for Reproductive Toxicity Caused by Anti-cancer Drug, Cisplatin, in Male Rats, Recent Patents on Anti-Cancer Drug Discovery 2017; 12 (1) . https://dx.doi.org/10.2174/1574892811666161026111721

DOI https://dx.doi.org/10.2174/1574892811666161026111721	Print ISSN 1574-8928
Publisher Name Bentham Science Publisher	Online ISSN 2212-3970