Hypersensitivity Reactions to Non-Steroidal Anti-Inflammatory Drugs

Title:Hypersensitivity Reactions to Non-Steroidal Anti-Inflammatory Drugs

Volume: 22 Issue: 45

Author(s): Inmaculada Dona, Maria Salas, James R Perkins, Esther Barrionuevo, Francesco Gaeta, Jose A. Cornejo-Garcia, Paloma Campo and Maria Jose Torres

Affiliation:

Keywords: Non-steroidal anti-inflammatory drugs, hypersensitivity reactions, cross-intolerance, selective reactions, IgE, T-cell response, classification, blended reactions.

Abstract: Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the leading causes of hypersensitivity reactions to drugs, and they are classified in two groups: those induced by nonspecific immunological mechanisms (non-allergic or cross-intolerance (CI) reactions), or by specific immunological mechanisms (allergic or selective reactions (SR)). The pathogenesis of CI is associated with their pharmacological activity (COX-1 inhibition), with symptoms due to an imbalance in the arachidonic acid pathway, independently of their chemical structure. SRs are mediated by specific IgE- or by a T-cell response and can be induced by a single NSAID or a class of chemically related NSAIDs, with patients tolerating chemically unrelated compounds. NSAIDs hypersensitivity reactions have been classified in five main groups: i) NSAIDs-exacerbated respiratory disease (NERD); ii) NSAIDs-exacerbated cutaneous disease (NECD); iii) NSAIDs-induced urticaria/angioedema (NIUA); iv) Single NSAID–induced urticaria/angioedema or anaphylaxis (SNIUAA); v) Single NSAID–induced delayed reactions (SNIDRs). Although this classification described above is widely accepted by most authors some phenotypes such as blended reactions do not fit. Therefore more research is needed in this topic.

Cite this article as:

Dona Inmaculada, Salas Maria, Perkins R James, Barrionuevo Esther, Gaeta Francesco, Cornejo-Garcia A. Jose, Campo Paloma and Torres Jose Maria, Hypersensitivity Reactions to Non-Steroidal Anti-Inflammatory Drugs, Current Pharmaceutical Design 2016; 22 (45) . https://dx.doi.org/10.2174/1381612822666160928142814